Advances in Chemistry of Bioactive Compounds and their Therapeutic Uses: A Review of the Last Three Decades | Chapter 7 | Achievements and Challenges of Medicine and Medical Science Vol. 7

The field of bioactive compounds has witnessed significant advancements over the past three decades, resulting in the discovery of novel therapeutic agents and the improvement of existing ones. This comprehensive review explores developments in the chemistry of bioactive compounds, with an emphasis on synthesis, structural modifications, and wide-ranging therapeutic applications. Natural products remain invaluable sources of bioactive molecules due to their diverse chemical structures and biological activities. Synthetic modifications and analog development have enhanced the efficacy, selectivity, and safety profiles of these compounds. Biotechnological approaches have accelerated drug discovery and optimization processes, while advancements in drug delivery systems have improved the bioavailability and therapeutic index of drugs. Despite these advancements, challenges such as drug resistance, safety concerns, and regulatory hurdles persist. Future perspectives highlight the importance of personalized medicine, artificial intelligence in drug discovery, novel drug delivery technologies, and sustainable drug development. Continued interdisciplinary research and innovation are essential to overcome current challenges and fully harness the therapeutic potential of bioactive compounds, ultimately improving global health outcomes.

 

Author (s) Details

 

Gayatri Shankar Dhobale
Savitribai Phule Pune University, Pune, Maharashtra 411007, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/acmms/v7/3764

Study on Trace Amine-associated Receptor 1 (TAAR1) Ligand Neuron, D-neuron | Chapter 20 | Recent Developments in Medicine and Medical Research Vol. 4

 SEP-363856, a novel non-D2-receptor-binding medication, was found to be effective in a recent psychopharmacological research for the treatment of schizophrenia. The chemical is a full agonist for the trace amine-associated receptor 1 (TAAR1) as well as a partial agonist for the 5-hydroxytryptamin 1A (5-HT 1A) receptor. The TAAR1 ligand neuron, D-neuron, was discovered in the striatum and nucleus accumbens (Acc), a neuroleptic active location, in the human brain, but not in the monkey brain's analogous area. A total of 154 post-mortem brains were used to research human D-neuron functions, and a modified immunohistochemistry approach using high-quality antibodies against monoamine-related chemicals was used. In post-mortem brains with schizophrenia, the number of D-neuron in the caudate nucleus, putamen, and Acc was reduced. In Acc., the drop was statistically significant (p0.05). I suggested the "D-cell hypothesis of schizophrenia," which states that NSC dysfunction-based D-neuron decrease represents the cellular and molecular foundation of mesolimbic dopamine (DA) hyperactivity, progressive pathogenesis, and the therapeutic potential of TAAR1.

Author(S) Details

Keiko Ikemoto
Department of Psychiatry, Iwaki City Medical Center, Iwaki, Japan.

View Book:- https://stm.bookpi.org/RDMMR-V4/article/view/4185

Recent Advances on Natural Product Inspired Design and Synthesis of Medicinally Active Heterocycles | Book Publisher International

 Mother nature is a key source of treatment for practically all diseases, as well as inspiration for synthetic and medicinal chemists to explore new chemical spaces. Natural molecules have proven to play an important function in medicine and chemotherapy. These natural chemicals have gradually encouraged synthetic chemists to change natural product molecules in desired ways in order to incorporate medicinal potential. Natural product inspired synthesis is the result of this trend of modifying natural molecules in desirable ways. The proven importance of natural molecules and natural product inspired synthesis prompted us to write this book, which includes a comprehensive list of natural product derived molecules, extensive synthetic methodologies, and biological potential against various targets. The tiny synthetic compounds have been narrowed down and classified based on their biological activity and targets. Anticancer, antidiabetic, antifungal, antibacterial, antitubercular, antileishmanial, and other activities were included in the study. The pathway for derivatization of various pharmacophoric nuclei selected from bioactive natural compounds has been investigated. The molecule's detailed synthesis methodology is presented in an easy-to-understand format, allowing the structure and activity of the molecule to be linked to specific targets.

Author(s) Detailts

Vishwa Deepak Tripathi
Department of Chemistry, M. K. College Laheriasarai, Lalit Narayan Mithila University, Darbhanga, Bihar, India.

View Book:- https://stm.bookpi.org/RANPIDSMAH/article/view/1892