Showing posts with label gestational weight gain. Show all posts
Showing posts with label gestational weight gain. Show all posts

Thursday, 29 February 2024

Study about Young Women to Specifics of Human Sexuality/Reproduction | Chapter 11 | Advancement and New Understanding in Medical Science Vol. 5

This paper explains first, concerning physiological vaginal first birth (primiparity) why young women should consider delivering her first baby before the age of 26 (there is a linear association between maternal ages and healthy deliveries). Second, because of the comparatively large human fetal brain, nutritional maternal-foetal exchanges are twice those of other mammals (per body-mass ratios). There is a lack of awareness among young of the very specific reproductive and sexual strategies of humans as compared to other mammals. Homo sapiens appeared some 300,000 years ago and our female ancestors delivered obligatorily vaginally prior to the development of medical interventions (such as caesarean sections, a safe procedure only since the 1960’s). Furthermore, women are unique among the 4,300 mammal species suffer from a harmful complication of pregnancy, preeclampsia (especially during a first pregnancy). But, as the human species has retained the hemochorial placenta, that first appeared in mammalian evolution, women face the great challenge of immunological tolerance towards the male partner’s tissues during the nine months of gestation. This major challenge occurs during the first pregnancy and tolerance is related to semen exposure prior to conception.  In subsequent additional pregnancies, immunological recognition is largely achieved through the initial pregnancy. This is why for a first pregnancy (nulliparous woman or multiparous woman with a new male partner), it is preferable to conceive after a delay of 6 months of non-barrier contraception before planning conception. Short-term sexual cohabitation after the couple's constitution (partially recognized male tissue) may result in incomplete embryo implantation, which can cause problems including early-onset preeclampsia and/or fetal growth restriction. Third, to have a baby neither too small, nor too big, women overweight or obese at the beginning of any pregnancy must gain less weight during the 9 months of gestation as compared to their leaner counterparts. The optimal gestational weight gain may be acknowledged during the first prenatal visit, with, a goal to achieve during the next 7- 8 months of pregnancy.


Author(s) Details:

Pierre-Yves Robillard,
Service de Néonatologie, Centre Hospitalier Universitaire Sud Réunion, BP 350, 97448 Saint-Pierre Cedex, La Réunion, France and Centre d’Etudes Périnatales Océan Indien (CEPOI), Centre Hospitalier Universitaire Sud Réunion, BP 350, 97448 Saint-Pierre cedex, La Réunion, France.

Please see the link here: https://stm.bookpi.org/ANUMS-V5/article/view/13340

Friday, 19 January 2024

Women and Pregnancies as an Immediate Target against the Obesity Epidemic | Chapter 14 | Advancement and New Understanding in Medical Science Vol. 1

People with obesity worldwide have become a major challenge in this 21st century with an apparent irresistible rise of this epidemic since the 1970’s. Nowadays, it is evaluated that obese people (≥ 30 kg/m²) represent some one billion inhabitants (out of seven) on this planet. The author wishes to enlarge an important current debate among obstetricians trying to sensitize specialists of obesity/endocrinology/ nutrition, and make them aware of a possible very important debate: having a “normal shaped” baby (neither too small, nor too big, 10% of SGA, small for gestational age and 10% of LGA, large for gestational age), is possible by an optimal gestational weight gain (optGWG) during pregnancy. This is a simple- mathematical linear equation, y= ax+b (y being optimal gestational weight gain, optGWG, x being pre-pregnancy body mass index, ppBMI). Beginning with severe obesity (36 kg/m²), women should not gain weight during their pregnancy, while they should lose weight in higher BMIs (e.g., losing 6 kg for a 40 kg/m² morbid obese). This is predictable since the first trimester of pregnancy. This chapter concluded that besides actively counter balancing morbid effects of high BMIs in pregnancies (and, importantly for the future of mankind, by avoiding a lot of macrosomic and LGA newborns), should imply new habits in women’s future lives afterwards.

Author(s) Details:

Pierre-Yves Robillard,
Service de Néonatologie, Centre Hospitalier Universitaire Sud Réunion, BP 350, 97448 Saint-Pierre Cedex, La Réunion, France and Centre d’Etudes Périnatales Océan Indien (CEPOI), Centre Hospitalier Universitaire Sud Réunion, BP 350, 97448 Saint-Pierre Cedex, La Réunion, France.

Please see the link here: https://stm.bookpi.org/ANUMS-V1/article/view/13031

A Retrospective Analysis on the Urgent Need to Optimize Gestation Weight in Overweight/Obese Women to Lower Maternal-Fetal Morbidities: 59000 Singleton Term Pregnancies | Chapter 1 | Advancement and New Understanding in Medical Science Vol. 1

Objective: This study primarily focuses on examining the criticalities of optimizing gestational weight for obese women to reduce fatal morbidities. We retrospectively did a simulation applying the optimal gestational weight gain (optGWG) equation (that we proposed in 2018) on our population, and observed if its effect on maternal/fetal morbidities in singleton term pregnancies (≥37 weeks).

Design: This is a Retrospective observational study.

Setting: The setting for this study was in a single large tertiary maternity unit in Reunion Island, Indian Ocean, overseas French department.

Population or Sample: All consecutive singleton births delivered at the Centre Hospitalier Universitaire Hospitalier Sud Reunion's maternity was the chosen population for this study. A standardized epidemiological perinatal database was used here.

Methods: This study employed mathematical simulation on a 19-year historical cohort (2001-2019)'. Data was presented as numbers and proportions for categorical variables and as mean and Standard Deviation (SD) for continuous ones.

Main Outcome Measures: Five Maternal/fetal morbidities were measured for this study.

Results: Beginning with overweight women, and enlarging the effect with the rise of different obesities (class I to III) and considering maternal pre- pregnancy BMI (ppBMI), individualized counselling women on their GWG (optimal gestational weight gain, optGWG) lowers significantly maternal/ fetal morbidities: in a logistic regression model among overweight/obese women, with the outcome optGWG, several morbidities have a negative coefficient as independent factors: cesarean-section, birthweight ≥ 4000 g, term preeclampsia, lowering the effect of rising maternal ppBMI per increment of 5 kg/m² (coefficient -0.13), all p < 0.001. Dietary and lifestyle interventional studies have reduced GWG by 0.7kg or 3.7kg and had no effect on other pregnancy and birth outcomes including GDM, PE, PIH, LGA and macrosomic infants.

We propose as a prediction to be verified in future prospective studies that a follow-up and counselling since the first prenatal visit should also lower gestational diabetes mellitus rates.

Conclusion: We may have significant health (and cost) benefits by lowering c-section rates, term preeclampsia, macrosomic babies and LGA babies in overweight/obese women and low-birthweight babies in lean women. We may have much to win from reducing weight gain during pregnancy in overweight/obese women. It is urgent to verify and establish in all continents the specific linear curve of optGWG for each geographic/ethnic area.

Author(s) Details:

Pierre-Yves Robillard,
Service de Néonatologie, Centre Hospitalier Universitaire Sud Réunion, Saint-Pierre Cedex, La Réunion, France and Centre d'Etudes Périnatales Océan Indien (CEPOI), Centre Hospitalier Universitaire Sud Réunion, Saint-Pierre Cedex, La Réunion, France.

Gustaaf Dekker,
Department of Obstetrics & Gynaecology, University of Adelaide, Robinson Institute, Lyell McEwin Hospital, Australia.

Malik Boukerrou,
Centre d’Etudes Périnatales Océan Indien (CEPOI), Centre Hospitalier Universitaire Sud Réunion, Saint-Pierre Cedex, La Réunion, France and Service de Gynécologie et Obstétrique, Centre Hospitalier Universitaire Sud Réunion, BP 350, 97448 Saint-Pierre Cedex, La Réunion, France.

Brahim Boumahni,
Service de Neonatologie, Centre Hospitalier Universitaire Sud Reunion, Saint-Pierre Cedex, La Reunion, France.

Thomas C Hulsey,
Department of Epidemiology, School of Public Health, West Virginia University, Morgantown WV, USA.

Marco Scioscia,
Department of Obstetrics and Gynaecology, Policlinico of Abano Terme, Abano Terme (PD), Italy.

Please see the link here: https://stm.bookpi.org/ANUMS-V1/article/view/12998