Extraction and Isolation of Natural Products | Chapter 4 | Natural Products Chemistry: From Discovery to Applications, Edition 1

Exploration and separation are crucial steps in the extraction of bioactive chemicals from natural sources, including plants, microorganisms, and marine life. This procedure involves the isolation of the target chemicals using techniques such as solvent extraction, distillation, and chromatography. The parameters involved in the extraction process include the selection of the solvent, temperature, and pH level. Therapeutic indices, thermal properties, unique biochemical reactivity, crystallization, filtration, and intricate chromatographic procedures contribute to the preservation of the purity of isolated substances. This abstract emphasizes the optimization of these technologies to maximize yield, purity, and bioactivity, which are crucial for future pharmaceutical and commercial applications.

 

Author (s) Details

 

Sarika Arora
Department of Chemistry, School of Sciences, IFTM University, Moradabad-244102, Uttar Pradesh, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48388-70-4/CH4

Simulation Database System of the Active Ingredients in Compound Decoction of Chinese Medicine | Chapter 9 | Diagnostic and Treatment Advances in COVID-19 and SARS-CoV-2

 Compound decoction is the main form of clinical application of Chinese medicine. Current research on active ingredients of Chinese medicine has commonly relied on chemical separation and extraction technology by using organic solvents, which was very different from the traditional method of water-phase boiling. Difference in preparation methods would lead to awareness discrepancy in active ingredients. The present system simulated the decoction boiling conditions of traditional Chinese medicine, and established databases of related components and their interaction, and analysed the possible active ingredients existed in compound decoction via database mining, statistical analysis and other technologies.

Author(s) Details:

Long Zhang,
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China.

Hua Zhao,
Agricultural College, Gansu Agricultural University, Lanzhou 730070, PR China.

Gang Zhou,
Life Science College, Northwest Normal University, Lanzhou 730070, PR China.

Tianshui Niu,
Life Science College, Northwest Normal University, Lanzhou 730070, PR China.

Jianshe Yang,
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China and Agricultural College, Gansu Agricultural University, Lanzhou 730070, PR China.

Please see the link here: https://stm.bookpi.org/DTACSC/article/view/9560

Experiments on Antiproliferative Activity of Aqueous Extract of Piper Betle L. and Psidium guajava L. on KB and HeLa Cell Lines | Chapter 3 | Research Trends and Challenges in Medical Science Vol. 6

 The objective of the current study was to determine the effect of Psidium guajava and Piper betle aqueous extracts on the proliferation of cancerous cell lines, i.e. KB and HeLa cell lines. The IC50 of P. guajava and P. betle was calculated at 29.0 ± 0.4 and 29.5 ± 0.3 μg / ml , respectively, using the neutral red cytotoxicity assay, suggesting that both plant extracts are equally potent for the treatment of cancerous oral epidermal lesions. A less potent anti-proliferative activity was, however, reported by P. guajava with an IC50 of 51.0 ± 0.6 μg / ml against the HeLa cell line, while P. betle extract did not affect HeLa proliferation. The antiproliferative activity shown in nasopharyngeal epidermoid carcinoma cells by both P. guajava and P. betle aqueous extracts is indicative of their ability to be developed as neutraceuticals in the prevention and management of cancerous oral epidermal lesions. An additional benefit that would complement the use of P. guajava and P. betle as adjuncts in the formulation of oral health care products would be this cytotoxic property.

Author(s) Details

Professor A. R. Fathilah
Department of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia and Faculty of Dental Medicine, Universitas Airlangga Surabaya, Indonesia.

R. Sujata
Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.

A. W. Norhanom
Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.

M. I. Adenan
Universiti Teknologi MARA Jengka Campus, 26400 Bandar Tun Abdul Razak, Pahang, Malaysia.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/313