Utilizing Meconium Transferrin and Ferritin as Metrics for Fetal Homeostasis | Chapter 5 | Innovations in Biological Science Vol. 1

 Aim: The aim of this study was to measure transferrin and ferritin concentrations in meconium specimens and assess their possible correlation with birth weight in study neonates.

Introduction: The molecular mechanisms regulating homeostasis in the developing fetus have not been satisfactorily elucidated. Meconium deposited intrauterine contains substances accumulated in the intestine that may indicate the development and growth of the fetus.

Objective: Measurement of transferrin and ferritin concentrations in meconium and checking the interconnections between these proteins with their effects on the development and growth of the fetus.

Methodology: The study was conducted in a group of 125 newborns, whose first portion of meconium was collected immediately after birth. This clinical material was homogenized. Ferritin and transferrin concentrations were determined in homogenates using commercial ELISA tests (enzyme-linked immunosorbent assay).

Results: Higher birth weight was associated with lower ferritin concentrations in meconium (r = −0.22, p = 0.015). In neonates with a birth weight of more than 3750 g, there was a positive correlation between transferrin and ferritin concentrations (r = 0.51, p = 0.003). With meconium transferrin concentrations above 43.52 µg/g, a negative correlation between transferrin and ferritin was established (r = −0.37, p = 0.036), while with transferrin concentrations below 43.52 µg/g, the correlations between the birth weight and the meconium transferrin and ferritin concentrations were negative (r = −0.61, p < 0.001 and r = −0.43, p = 0.017, respectively).

Conclusion: The concentrations of transferrin and ferritin in meconium show mutual associations, the statistical significance of which increases proportionally with the weight of the newborn.  Setting reference limits for ferritin and meconium transferrin concentrations, as well as their correlation with clinical parameters during pregnancy, may help evaluate how intrauterine life affects the neonate's health and how well it adjusts to extrauterine life.

Author(s) Details:

Ewa Skarzynska,
Department of Laboratory Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland.

Klaudia Mularczyk,
Department of Laboratory Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland.

Tadeusz Issat,
Department of Obstetrics and Gynecology, Institute of Mother and Child, 01-211 Warsaw, Poland.

Artur Jakimiuk,
Department of Obstetrics, Women’s Diseases and Gynecologic Oncology, National Medical Institute of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland and Center for Reproductive Health, Institute of Mother and Child, 01-211 Warsaw, Poland.

Barbara Lisowska-Myjak,
Department of Biochemistry and Pharmacogenomics, Medical University of Warsaw, 02-097 Warsaw, Poland.

Please see the link here: https://stm.bookpi.org/IBS-V1/article/view/14014

Assessment of Pregnancy Outcomes with Maternal Age: A Retrospective Study | Chapter 9 | Current Innovations in Medicine and Medical Science Vol. 2

 This study specifies placental and neonatal percentage growth trajectories in different maternal age groups. One of the most important factors for successful pregnancy outcome is maternal age. Extreme maternal age adversely affects fetal and placental growth patterns.

 This study was conducted on 391 placentas obtained from her 6-month consecutive deliveries from the obstetrics and gynecology department of a teaching hospital in North Karnataka, India.

 The age distribution of the 391 mothers shows a mean of 23.6 years and a standard deviation of 3.7 years, with 7.2% under her 20s and 7.6% over her 30s. Birth weight percentiles and placental morphometry did not show a consistent association with increased maternal age. This study showed a consistent increasing trend in birth weight percentiles for different  maternal age groups only in the higher percentiles (75th to 95th), whereas placental morphometric percentiles showed no consistent relationship with age. Placental morphometric percentiles showed no consistent relationship with maternal age except for placental weight at the 5th and 50th percentiles and  placental surface area at the 25th percentile.

Author(s) Details:

Rupa L. Balihallimath,
Department of Anatomy, Gadag Institute of Medical Sciences, Gadag, Karnataka, India.

M. K. Jayalaxmi,
Department of Physiology, Gadag Institute of Medical Sciences, Gadag, Karnataka, India.

Anita M. Gan,
Departmetnt of Obstetrics and Gynecology, Jawaharlal Nehru Medical College, Belgaum, Karnataka, India.

Naresh Kumar Tyagi,
Department of Biostatistics and Epidemiology, Gadag Institute of Medical Sciences, Jawaharlal Nehru Medical College, Belgaum, Karnataka, India.

Please see the link here: https://stm.bookpi.org/CIMMS-V2/article/view/8226

Assessment of Reference Curves of Birth Weight, Length, and Head Circumference for Gestational Ages: A Study from Yogyakarta, Indonesia | Chapter 1 | Research Aspects in Biological Science Vol. 7

 The reference curve for birth weight is intended to identify at-risk infants who require monitoring and evaluation. Indonesian reference curves were developed about eight years ago using only information from teaching hospitals with a narrow range of gestational ages. Depending on the birth curve being utilised, the prevalence of high risk neonates varies. The aim of this study was to update the reference curves for birth weight, length, and head circumference, as well as to compare the birth weight curves of boys and girls, first children and later children, and those in prior research. The Maternal-Perinatal database's data were taken. Only live singletons with gestational ages between 26 and 42 weeks who were delivered at Sardjito Hospital, five district hospitals, or five health facilities in Yogyakarta within 24 hours of birth were included. There were 54,599 live births of singletons. Growth curves for birth weight, length, and head circumference were created for males (53.3%) and girls (46.7%). But compared to children born later, it was much lower among first-borns. The mean birth weight was lower than in Lubchenco's study. There were no changes between the Indonesian study by Alisyahbana and this one for term newborns, however preterm infants had a lower mean birth weight. Using revised neonatal reference curves for birth weight, length, and head circumference, it was crucial to identify newborns that needed care and to categorise high risk newborns in a specific location.

Author(s) Details:

Ekawaty L. Haksari,
Department of Child Health, Faculty of Medicine, Universitas Gadjah Mada, Sardjito General Hospital, Jl. Kesehatan No. 1, Yogyakarta 55284, Indonesia.

Harrie N. Lafeber,
Department of Pediatrics, Vrije Universiteit Medical Center, P.O. Box 7057,1007 MB Amsterdam, Netherlands.

Mohammad Hakimi,
Faculty of Medicine, Universitas Gadjah Mada /Sardjito General Hospital, Jl. Kesehatan No. 1, Yogyakarta 55284, Indonesia.

Endy P. Pawirohartono,
Department of Child Health, Faculty of Medicine, Universitas Gadjah Mada, Sardjito General Hospital, Jl. Kesehatan No. 1, Yogyakarta 55284, Indonesia.

Lennarth Nyström,
Public Health and Clinical Medicine, Umeå University, SE-901 87 Umeå, Sweden.

Please see the link here: https://stm.bookpi.org/RABS-V7/article/view/8040

Assessment of Retinopathy of Prematurity (ROP) in Semi Urban Population: Risk Factors and Clinical Findings | Chapter 21 | Issues and Developments in Medicine and Medical Research Vol. 6

 The goal of this study is to look into numerous potential risk factors for the development of Retinopathy of Prematurity (ROP) and to figure out how common ROP is in the study population. This one-year prospective observational study was conducted at the Department of Ophthalmology, Government Thanjavur Medical College, Thanjavur, with 102 babies meeting the inclusion criteria who were subjected to a complete fundus examination with an indirect ophthalmoscope and followed up until 45 weeks after conception. ROP was shown to be more common in male babies (57.8%), but the difference between male and female babies (42.1%) was not statistically significant. As a result, the findings imply that there are no clear gender-related risk factors in the development of ROP. ROP is the most common cause of preventable childhood blindness in India. The difficulty is simply identifying those who would benefit from vision-saving therapy. Screening and treatment of ROP should begin as soon as possible.

Author(S) Details

Sangamithira Mathiyalagan
Government Thanjavur Medical College, Thanjavur, Tamilnadu, India.

View Book:- https://stm.bookpi.org/IDMMR-V6/article/view/5695

Determining the Placental-Birth Weight Ratio at Term at the Benue State University Teaching Hospital, Makurdi, North-Central Nigeria: A CrossSectional Study | Chapter 3 | Issues and Development in Health Research Vol. 1

 Background: A neonate's birth weight is mostly determined by placental growth and function in the womb. The placental weight, neonatal birth weight, and placenta-birth weight ratio are all indirect measures of this important link. This emphasises the importance of placental weight as a key factor in newborn weight. The goal of this study was to evaluate the placental weight, birth weight, and placental-birth weight ratio in a group of pregnant women who came to our prenatal clinic. Methodology: From July 31, 2015, to June 30, 2017, a clinic-based cross-sectional study was conducted. Four hundred and forty-four (444) pregnant women who attended our antenatal clinic were randomly selected. A table-top beam weighing scale was used to quantify placental and birth weights within one hour after delivery. The statistical analysis was carried out using SPSS version 20.0, with a significance level of 0.05. The study included 444 women (with a mean age of 28.75 years, a mean parity of 1.5, and a mean gestational age at birth of 38.70 weeks). The average placental weight was 670 grammes, the average birth weight was 3300 grammes, and the average placental-birth weight ratio was 20.3. Two hundred and eighteen (49.1%) of the neonates were males, while 226 (50.9%) were females. The placental weight and the placental-birth weight ratio had a positive connection (X2 = 108.570; p-value = 0.001). There was a progressive decline in the PBWR with gestational age at term. Conclusion: As the birth weight and gestational age grew, so did the placental weight. With increasing gestational age, the placenta-to-birth weight ratio decreased.

Author (s) Details

P. O. Eka
Department of Obstetrics and Gynaecology, Benue State University Teaching Hospital, Makurdi, Nigeria.

T. Z. Swende
Department of Obstetrics and Gynaecology, Benue State University Teaching Hospital, Makurdi, Nigeria.

A. O. Ojabo
Department of Obstetrics and Gynaecology, Benue State University Teaching Hospital, Makurdi, Nigeria.

B. T. Utoo
Department of Obstetrics and Gynaecology, Benue State University Teaching Hospital, Makurdi, Nigeria.

A. A. Ornguze
Department of Obstetrics and Gynaecology, Benue State University Teaching Hospital, Makurdi, Nigeria.

S. K. Hembah- Hilekaan
Department of Obstetrics and Gynaecology, Benue State University Teaching Hospital, Makurdi, Nigeria.

View Book :- https://stm.bookpi.org/IDHR-V1/article/view/2154