The Positive Effect of Lithium for Elevated Specific Activities of Alkaline Phosphatase and β-Galactosidase on the Liver and Brain Cell Membrane Integrity in Young and Old Aged Rats | Chapter 4 | New Innovations in Chemistry and Biochemistry Vol. 4

 Differentiate the specific activity of Alkaline Phosphatase and -Galactosidase in the brain and liver of LiCl2 treated young and old aged rats compared to their controls. Materials and Methods: The levels of Alkaline phosphatase and -galactosidase were measured in four groups of male wistar rats (each n=5) throughout the course of 10 and 20 days. LiCl2 cured the brain and liver of young and old rats better than the control. LiCl2 increases protein content, which is essential for the activation of aged brain cells. When compared to their control, alkaline phosphatase and -Galactosidase demonstrated higher specific activity in the brain and liver of young and old rats treated with LiCl2 for 10 and 20 days, respectively. Indeed, alkaline phosphatase activity was significantly increased for 10 and 20 days. In comparison to their control group, LiCl2 treated young brain showed 16.77 0.309 and 27.74 0.237. When compared to their control, the young rat's brain showed 3.80 0.230, while the adult rat's brain showed 14.28 0.215 and 16.30 0.24, respectively. 8.65 0.304 nm/min/mg of protein; similarly, young liver activity was 19.51 0.487 and 21.28 0.317 as compared to their control 3.67 0.402; and finally, old liver activity was 15.02 0.355 and 18.45 0.439 as compared to their control 3.26 0.304 nm/min/mg of protein. Conclusion: In wistar rats brain and liver cells, both membrane bound Alkaline Phosphatase and -Galactosidase enzymes displayed greater specific activity for LiCl2 treatment. In the rat liver and brain, lithium has a beneficial influence on -galactosidase in both young and elderly brain cells, while having a stronger positive effect on Alkaline phosphatase for cell membrane integrity.

Author (S) Details

M. Prabha

Department of Biotechnology, Ramaiah Institute of Technology, India.

K. N. Sushma

Department of Biotechnology, Ramaiah Institute of Technology, India.

P. Suneetha

Department of Biochemistry, MLACW, India.

R. R. Siva Kiran

Chemical Engineering, RIT, India.

View Book :- https://stm.bookpi.org/NICB-V4/article/view/4323

Association of Acid and Alkaline Phosphatase among Thyroid Patients: A Brief Study | Chapter 8 | Highlights on Medicine and Medical Science Vol. 8

 Thyroid hormones are secreted by the thyroid gland, and when these hormones malfunction, thyroid diseases occur. They are one of the most common endocrine illnesses in the world, ranking second only to diabetes. Hypothyroidism and hyperthyroidism are the two most common thyroid conditions. These disorders are linked to a number of risk factors, including aberrant iodine levels and specific molecular indicators. The goal of this research is to learn more about the link between acid and alkaline phosphatase enzymes and thyroid diseases. The hypo and hyper thyroid patients in this study had higher levels of acid phosphatase than the controls. Whereas alkaline phosphate levels are lower in hypothyroid patients than in controls, it is closer to normal levels in both patients and controls in hyperthyroid patients. In the introduction and the results, the linked literature correlation is explored in detail.

Author (s) Details

B. Dharani Priya
Former Coordinator, BVK PG College, Visalakshinagar, Visakhapatnam-43, India.

U. Prathyusha
Former Coordinator, BVK PG College, Visalakshinagar, Visakhapatnam-43, India.

View Book :- https://stm.bookpi.org/HMMS-V8/article/view/2168

Risk Factors, Dietary and Clinical Profile of Patients with Non-alcoholic Steatohepatitis (NASH): Acrosssectional Study | Chapter 2 | Highlights on Medicine and Medical Science Vol. 3

 The term NASH was coined by Ludwig et al. NASH is a type of non-alcoholic steatohepatitis that includes steatosis, steatohepatitis, fibrosis, cirrhosis, and complications. The goal of this study is to look into the dietary, clinical, and other risk factors associated with NASH. Materials and Methods: The current study was conducted on 60 NASH patients over a six-month period in 2010 at the Department of Medicine, GMC, Jammu. A variety of NASH-related risk factors were examined in all NASH patients. A thorough clinical examination as well as a detailed history were performed. Results: Of the 60 patients, 28 (46.66%) were males and 32 (53.32%) were females. 85 percent of the patients were between the ages of 31 and 70. Conclusion: In our study, non-vegetarians made up 73.33 percent (44/60) of the patients, while asymptomatic people made up 26.6 percent (16/60). Right subcostal pain was the most common symptom (69.33 percent ). Obesity, hyperlipidemia, and diabetes mellitus were found to be significantly associated with NASH in this study.

Author (S) Details

Dr. Vinod Kumar
GMC Doda, JK, India.

Dr. Ritu Bhagat
GMC Doda, JK, India.

Dr. Ahmar Javid Azad
GMC Doda, JK, India.

View Book :- https://stm.bookpi.org/HMMS-V3/article/view/1593