Unusual Appearance of Multifocal Nodular Fatty Liver Infiltration with Hemosiderosis in a Patient with Leukemia: An Approach towards Challenge in Diagnosis | Chapter 07 | Issues and Developments in Medicine and Medical Research Vol. 4

 The goal of this study was to describe one of the difficulties in diagnosing liver abnormalities in the context of cancer diagnosis, as well as the impact on patient management. In computed tomography (CT) and magnetic resonance imaging (MRI), hepatic steatosis is a common result (MRI). Chemotherapy increases the risk of fatty liver infiltration as well as hemosiderosis. Multiple focal nodular fatty infiltration with unusual appearance and behaviour is uncommon, and when it is associated with a history of malignancy and/or infection, it presents a dilemma in which a confident diagnosis may not be rendered by MRI, necessitating a diagnostic biopsy to resolve the uncertainty in diagnosis. We discuss a case of a patient who got a fungal lung infection while receiving salvage chemotherapy for a second relapse of acute myelogenous leukaemia (AML). On MRI, there were progressive target-shaped focal liver lesions with distinctive fatty signal intensity, as well as evidence of hemosiderosis of the liver parenchyma. To achieve the final diagnosis of focal fatty infiltration and rule out the differential diagnoses of liver abscesses and leukaemia infiltration, target and non-target liver trucut biopsies were required.

Author(S) Details

M. El Khaldi
Department of Diagnostic Radiology, King Hussein Cancer Center, Jordan.

M. Al Hussaini
Department of Pathology, King Hussein Cancer Center, Jordan.

M. Abu Shattal
Department of Diagnostic Radiology, King Hussein Cancer Center, Jordan.

H. Abu Jazar
Bone Marrow Transplantation and Medical Oncology Departments, King Hussein Cancer Center, Jordan.

M. Swaidan
Department of Diagnostic Radiology, King Hussein Cancer Center, Jordan.

View Book:- https://stm.bookpi.org/IDMMR-V4/article/view/5544

Granulomatous Lobular Mastitis: A Clinicopathological Study | Chapter 4 | Highlights on Medicine and Medical Science Vol. 17

 Granulomatous Lobular Mastitis is a rather uncommon illness. This condition resembles cancer and tuberculosis. This syndrome is characterised by granulomatous inflammation with multinucleated large cells and epithelioid histiocytes. The inflammation is concentrated in the lobules. The purpose of this study is to look at the clinical and pathological features of eight cases of granulomatous lobular mastitis, as well as the literature.

The research is based on a prospective observational study. There were a total of eight patients examined. The investigations are now concluded. The patient was given Erythromycin 250 mg qid for seven days, Tinidazole 500 mg bid for two months, and steroids for seven days. After the tumours were removed, the sinuses were excised, and the abscesses were drained, oral steroids were given. There was a six-month follow-up.

The patients, who ranged in age from 18 to 36, were usually multiparous and nursing. In three cases, the lesion was found to be malignant, while in five others, it was found to be benign. Oral contraceptive tablets were used by the majority of the patients. In three cases, suppuration was observed, while sinuses were discovered in two others. On histological examination, a granulomatous inflammation centred on the lobules was found.

Conclusion: The diagnosis of granulomatous lobular mastitis should be established very carefully to avoid misunderstandings with malignancy, tuberculosis, fungal infection, sarcoidosis, mammary duct ectasia, cystic abnormalities in the breast with over palpation, and puerperal mastitis with over palpation. Despite its rarity, pathologists and surgeons must have a solid understanding of the disease in order to better its identification.

Author (S) Details

Sapna Goel
Department of Pathology, SHKM Government Medical college, Nalhar, Nuh, Mewat, Haryana, India.

Kanwar Singh Goel
Department of General Surgery, Faculty of Medicine & Health Sciences, (SGT Medical College) Under SGT University, Budhera, Gurugram, Haryana, India.

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Necrotizing Fasciitis as a Complication of Odontogenic Abscess | Chapter 13 | Highlights on Medicine and Medical Science Vol. 1

 Infections in the mouth can become serious and spread. Necrotizing fasciitis is an uncommon infection that affects primarily immunocompromised persons. It usually manifests as a significant complication of dental infections, impairing the patient's general health and even posing a life-threatening hazard. It is necessary to recognize the clinic quickly in order to identify it, as well as the use of imaging techniques to determine the extent of the affection caused by Necrotizing Fasciitis. Medical (wide range antibiotics and multidisciplinary therapy) as well as lengthy and vigorous surgery are used to treat necrotizing fasciitis. The importance of understanding Necrotizing Fasciitis will aid in bettering patient treatment, improving prognosis, acting quickly, and limiting the disease. As a result, it necessitates understanding as well as emergency management. The following essay goes over Odontogenic Necrotizing Fasciitis in great detail.

Author (s) Details

Juárez-Rebollar Alejandra Giselle
Department of Oral and Maxillofacial Surgery, National Medical Center “Siglo XXI” (IMSS), Mexico.

Juárez-Rebollar Daniel
Department of Neurosurgery, Regional Hospital Lic. Adolfo López Mateos, Mexico.

Juárez-Paredes Celso Marcelo
Department of Gerontology, Mexican Institute of Social Security (IMSS), Mexico.

View Book :- https://stm.bookpi.org/HMMS-V1/article/view/1186