Semen Characteristics and Superoxide Dismutase and Malondialdehyde Levels in Peshmerga Forces Exposed to Chemical Weapons during the ISIS-Related War| Chapter 2 | Cutting Edge Research in Biology Vol. 3

 The labeling of chemical armaments as “weapons of mass destruction” focal points their possible damaging results on many civilians’ fitness. The effect of chemical arm agents has existed documented to cause reproductive toxicity and have unfavorable effects on beginning, leading to unproductiveness in those exposed to those synthetic agents. This study reasonings the semen fluid and follows up the unprotected Peshmerga forces to the chemical armament during the ISIS war. A potential cohort study at which point 58 exposed Peshmerga in three chemical attacks, distinguished with the unchanging number of the non-exposed Peshmerga. Semen fluid reasoning was performed for all, makeing inquiries after individual year. The serum level of two together MDA and SOD was measured. An individual’s BMI was premeditated. The participants’ mean age in this place study is (32.5) years in the case group while (35.5) age in the control group, with a standard deviation of 5 age in both groups. All players are male, and no gender effect be visualized. All chronic sicknesses have been forbade from the study. The mean body mass index is 22.4, accompanying a standard deviation of about 3.1 kg/m. Hypospermia grown in 18% of the exposed group (20% of the total shareholders), oligospermia (20% overall, only 3% of these in the non-exposed), and dropped motility in 19% of all participants, but 16 concerning this 19% where the unprotected group with important relative risk results, while morphology not exchanged in   both groups, again the findings showed that meaningful elevation in MDA level and SOD exercise. Chemical weapons can considerably affect beginning fluid analysis and interpretation through determinable disturbances in the volume and report of sperm, while the portion of abnormal semen counts has been raised considerably in peoples unprotected to chemical armaments. However, the morphology of source fluid sperms has not changed alike, and it’s function cannot be estimated. Even when functioning, the genetic wrongs on future generations grant permission need further testing.

Author(s) Details:

Yasin Kareem Amin,
Hawler Medical University, College of Medicine General Directorate of the Medco Legal Institute of Kurdistan Region, Iraq.

Please see the link here: https://stm.bookpi.org/CERB-V3/article/view/9193

Effect of Orally Ebselen (SPI-1005) towards Glutathione and Malondialdehyde Blood Level and Otoacoustic Emissions Result in Soldiers with Acoustic Trauma Risk | Chapter 5 | Technological Innovation in Pharmaceutical Research Vol. 5

 Excessive noise exposure can cause acoustic trauma to the inner ear structure (cochlea) by creating mechanical and metabolic (oxidative) stress (TA). Oxidative stress, which is induced by an increase in free radical ROS/RNS in the organs of Corti, causes apoptosis and necrosis of cochlear hair cells. Increased malondialdehyde (MDA), decreased glutathione peroxidase (GPx) enzyme, and aberrant otoacoustic emission value were all signs of oxidative stress (refer). Endogenous antioxidant enyzme (superoxide dismutase/SOD, catalase/CAT, and GPx) mediated the defence mechanism against oxidative stress. The glutation peroxidase mimic's cellular mechanism was identical to that of GPx. The goal of this study was to see how a glutathione peroxidase mimic affected glutathione peroxidase and malondialdehyde levels in blood, as well as otoacoustic emission values in troops who were at danger of TA from a Howitzer 105 artillery weapon explosion. The study's design was a randomised, double-blind, placebo-controlled clinical trial on 34 new recruit troops in the Indonesian Army's Artillery Academy, during which the soldiers were trained to fire the Howitzer 105 artillery weapon, from July 7th to July 10th, 2014 in Cimahi and Batujajar. The participants were split into two groups: the exposure group (the ones who got the treatment) and the control group During the training, the exposure group received 200mg of glutathione peroxidase mimetic (Ebselen SPI 1005) orally once daily, while the control group received nothing. Before and after firing training, the levels of malondialdehyde and glutathione peroxidase in the blood, pure tone audiometry, and otoacoustic emission value (DPOAEs) were assessed in those two groups. The data was evaluated using parametric and nonparametric methods, as well as NNT (95 percent confidence interval) and significance value (p0.05). According to the findings of this study, the number of auditory trauma events in the control group was 23.5 percent, whereas the exposure group had 0 percent. The exposure group was 0%, and the DPOAEs test revealed that the control group was 47.1 percent abnormal/refer, while the exposure group was 100 percent normally/pass, with a statistically significant difference (p0.051). The group given Ebselen SPI 1005 had an increase of 82.4 percent erythrocyte GPx (NNT, 95 percent CI=1.889 [1.1593.016]; p=0.004), an increase of 88.2 percent plasma GPx (NNT, 95 percent CI=1.417 [0.970-1.775]; p0.001), a decrease of 100 percent erythrocyte MDA (NNT, 95 percent CI=2.125 [1.335-3.987]; p=0.01), a decrease in plasma MDA of 94.1 percent (NNT, 95 percent CI=2.125 [1.29-3.904]; p=0.01), and a 100 percent normal/pass DPOAEs value (NNT, 95 percent CI = 2.125 [1.335-3.987]; p=0.01). Giving Ebselen SPI 1005 to soldiers at risk of acoustic harm while firing a Howitzer 105 artillery weapon raised GPx levels in the blood, decreased MDA levels in the blood, and resulted in regular DPOAEs readings (pass).

Author (s) Details

S. Sasongko
ENT Department, Gatot Soebroto Army Central Hospital, Indonesia.

T. Boesoirie
ENT Department, Medical Faculty, Padjadjaran University, Indonesia.

I. Parwati
Clinical Pathologic Department, Medical Faculty, Padjadjaran University, Indonesia.

H. Sastramihardja
Clinical Pharmacological Department, Medical Faculty, Padjadjaran University, Indonesia.

J. Bashirudin
ENT Department, Medical Faculty, Indonesia University, Indonesia.

View Book : https://stm.bookpi.org/TIPR-V5/article/view/1241

A Cross-sectional Study on Quality of Life and Estimation of Biomarkers in COPD Patients of a Tertiary Care Centre in Eastern Region | Chapter 3 |Highlights on Medicine and Medical Science Vol. 1

 COPD (chronic obstructive pulmonary disease) is a worldwide health issue. The goal of this study was to look at how COPD affects quality of life and biomarker levels in COPD patients using particular biomarkers. A total of 116 COPD patients were included in the study, who were treated at a tertiary care center in the eastern portion of India. The GOLD standard was used to determine the severity of their COPD. Quality of life and biomarker levels were determined using the SGRQ-C and suitable biochemical techniques, respectively. Serum nitrate decreased (33.67 4.41 mol/L) whereas serum MDA increased (6.38 2.32 nmol/L), indicating enhanced nitrosative and oxidative stress, respectively. Overall, researchers discovered that the severity of COPD had a proportional impact on quality of life. There is an increase in nitrosative stress in COPD patients, as evidenced by a decline in NOS (serum nitrate), and an increase in oxidative stress, as seen by a high amount of MDA in the blood. There is a link between the severity of COPD and serum NOS and MDA levels.

Author (s) Details

Dr. Arijit Nag
Department of General Medicine, Calcutta National Medical College and Hospital, Kolkata, India.

Dr. Soma Chakrabarti
Department of Community Medicine, Calcutta National Medical College, Kolkata, India.

Dr. Anindya Dasgupta
Department of Biochemistry, Calcutta National Medical College, Kolkata, India.

View Book :- https://stm.bookpi.org/HMMS-V1/article/view/1176