Predictive Value of Anti-Müllerian Hormone for IVF Outcomes: A Study from Poissy Hospital, France | Chapter 15 | Medical Science: Trends and Innovations Vol. 10

Background: Anti-müllerian hormone (AMH) is a glycoprotein of gonadal origin belonging to the Transforming Growth Factor β family (TGF-β), secreted in women by granulosa cells. Assessment of ovarian reserve is an essential parameter in the evaluation of female infertility. It has been established that serum anti-müllerian hormone (AMH) is the best marker of ovarian reserve and predicts the quality of ovarian response to stimulation. However, there is some controversy about the prediction of pregnancy rates. Can the serum AMH assay predict the chances of successful In vitro fertilization (IVF)?

 

Objective: To analyze the association between AMH levels, the number of mature oocytes obtained by oocyte puncture after stimulation and the outcome of In vitro fertilization at the first attempt.

 

Methods: An analytical cross-sectional study with retrospective data collection on 123 patients who had consulted for a desire to conceive and undergone ovarian reserve evaluation followed by IVF in the assisted reproduction department of the Poissy-Saint-Germain-en-Laye Intercommunal Hospital Centre at its Poissy hospital site between January 2020 and March 2022.

 

Results: Of the 123 patients, 43.8% had normal AMH levels. At the end of stimulation, almost half of patients (52.84%) had a sub-optimal ovarian response and almost a quarter had a poor response (27.64%). We found a statistically significant positive correlation [r = 0.42 b = 0.70 CI 95% (0.43 - 0.97) p = 0.000] between AMH level and the number of mature oocytes collected. Of all patients with low AMH, 83.3% had a clinical pregnancy, while 61.1% of patients with normal AMH had no pregnancy. These differences were statistically significant (p = 0.001). AMH level was significantly associated with predicting ovarian response to stimulation and had a decreasing association with IVF outcome. Indeed, compared with patients with low AMH levels, those with normal AMH levels were 7 times more likely to have a good response to stimulation [OR = 7.12 CI 95% (1.98 - 30.79) p = 0.003] and less likely to achieve pregnancy after embryo transfer.

 

Conclusion: AMH assay is an important marker of ovarian reserve and predicts ovarian response to stimulation. It correlates with the number of mature oocytes that can be collected at puncture but does not predict the chances of IVF pregnancy. Therefore, unless constrained by the patient’s age, the AMH level should not justify a direct decision to donate oocytes; prior stimulation should be attempted.

 

Author (s) Details

 

A. A. Mwakila
Gynaecology-Obstetrics Department, Kinshasa University Clinics, University of Kinshasa, Kinshasa, Congo.

 

E. J. Mboloko
Gynaecology-Obstetrics Department, Kinshasa University Clinics, University of Kinshasa, Kinshasa, Congo.

 

K. D. Ngoyi
Gynaecology-Obstetrics Department, Kinshasa University Clinics, University of Kinshasa, Kinshasa, Congo.

 

I. G. Likinda
Anesthesia and Intensive Care Department, Kinshasa University Clinics, Protestant University of Congo, Kinshasa, Congo.

 

M. A. Mulinda
School of Public Health, University of Kinshasa, Kinshasa, Congo.

 

S. P. Mogwo
Gynaecology-Obstetrics Department, Kinshasa University Clinics, University of Kinshasa, Kinshasa, Congo.

 

B. C. Moangi
Gynaecology-Obstetrics Department, Kinshasa University Clinics, University of Kinshasa, Kinshasa, Congo.

 

B. C. Bikuelo
Gynaecology-Obstetrics Department, Kinshasa University Clinics, University of Kinshasa, Kinshasa, Congo.

 

M. J. Mboloko
Gynaecology-Obstetrics Department, Kinshasa University Clinics, University of Kinshasa, Kinshasa, Congo

 

 

Please see the book here:- https://doi.org/10.9734/bpi/msti/v10/4225

Importance of Air Filtration System Replacement to Improve the Embryo Quality in Assisted Reproduction Laboratory | Chapter 3 | New Visions in Medicine and Medical Science Vol. 9

 

Infertility is a common disease, which drives several couples to seek treatment with assisted reproduction techniques. In vitro fertilization plays a significant role in combatting infertility. However, many factors contribute to the efficiency of assisted reproductive techniques, such as the laboratory environment and air quality. Poor air quality in the IVF laboratory is a known risk factor in the culture of gametes and human embryos. Improving infrastructural conditions of the in vitro fertilization laboratory, such as the air quality, has profound positive effects on embryo culture. Poor environmental conditions reduce the rate of embryo formation and, therefore, of pregnancy. This review article presents important publications regarding the impact of air quality in human reproduction laboratories on embryo quality, pregnancy success, and live births. The studies demonstrate that replacing the air filtration system improves significantly the environmental air quality, and, consequently, improves laboratory parameters, such as the fertilization rate, the number of blastocysts, the embryo implantation rate, and the number of live births. On the other hand, improving air quality decreases the number of abortions. Therefore, environmental parameters that improve embryo quality and increase healthy childbirth rates must be the main targets for assisted reproduction laboratory quality control. More controlled studies on air quality should be performed with the aim of investigating how particulate filtration interferes with IVF results and provides an effective balance of costs and benefits of replacing the air filtration system in the context of human-assisted reproduction.

 

Author(s) Details:-

 

Karine Queiroz Poletto
Faculty of Medicine, Centro Universitário UNIRG, Gurupi, TO, Brazil.

 

Yanna Andressa Ramos de Lima
Center for Human Reproduction, Department of Gynecology and Obstetrics, Universidade Federal de Goiás, Goiânia, GO, Brazil.

 

Mário Silva Approbato
Center for Human Reproduction, Department of Gynecology and Obstetrics, Universidade Federal de Goiás, Goiânia, GO, Brazil.

 

Please see the link here:-  https://doi.org/10.9734/bpi/nvmms/v9/3789G

Determining the Association between Serum Estradiol Levels on hCG Trigger Day and Live Birth Rates in Non-PCOS Patients | Chapter 3 | Research Developments in Medicine and Medical Science Vol. 8

 This study aims to retrospectively resolve the association of antitoxin estradiol (E2) levels on human chorionic gonadotropin (hCG) trigger day and live beginning rates (LBRs) in women meeting with fresh embryo transfer and not presenting polycystic ovary syndrome. A total of 13,950 victims who had new embryo transfer between December 2013 and December 2019 were contained. LBR served as the key consequence indicator. After controlling for variables, a multivariable reversion analysis told a significant connection between serum E2 levels on the hCG cause day and LBR [relative risk (RR) 1.027, 95% assurance interval (CI) 1.007, 1.049]. Stratification study revealed thatthe LBR was positively joined (RR 1.052, 95% CI 1.004, 1.102) with all 1 ng/mL increase of serum E2 on the hCG trigger era for the subgroup with reduced antral follicle relies the trigger day. In particular, a two-piecewise uninterrupted regression model showed that when blood E2 content was less than 2.1 ng/mL, skilled was a positive equating (RR 1.188, 95% CI 1.057, 1.334) between antitoxin E2 and LBR with every accretion of 1 ng/mL E2.  However, the relationship betwixt E2 levels and LBR was not statistically significant (RR 1.002, 95% CI 0.971, 1.032) when the level of E2 was higher than the 2.1 ng/mL intonation point. Further prospective studies are necessary to explore the likely mechanisms and to consolidate the friendship between antitoxin E2 levels on the hCG trigger day and LBR.

Author(s) Details:

Xiaoyuan Xu,
Department of Reproductive Medicine, Hebei Key Laboratory of Infertility and Genetics, Hebei Clinical Research Center for Birth Defects, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.

Aimin Yang,
Department of Reproductive Medicine, Hebei Key Laboratory of Infertility and Genetics, Hebei Clinical Research Center for Birth Defects, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.

Yan Han,
Department of Reproductive Medicine, Hebei Key Laboratory of Infertility and Genetics, Hebei Clinical Research Center for Birth Defects, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.

Wei Wang,
Department of Reproductive Medicine, Hebei Key Laboratory of Infertility and Genetics, Hebei Clinical Research Center for Birth Defects, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.

Guimin Hao,
Department of Reproductive Medicine, Hebei Key Laboratory of Infertility and Genetics, Hebei Clinical Research Center for Birth Defects, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.

Na Cui,
Department of Reproductive Medicine, Hebei Key Laboratory of Infertility and Genetics, Hebei Clinical Research Center for Birth Defects, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.

Please see the link here: https://stm.bookpi.org/RDMMS-V8/article/view/10202

Cooperative Effects of Semen and Seminal Fluid of Immunized Males on Embryo Development| Chapter 6 | Research Aspects in Biological Science Vol. 6

 The differential impact of spermatozoa and original liquid of male CD1 mice vaccinated with KLH antigen (keyhole limpet hemocyanin) on the advancement of pre-and post-implantation undeveloped organisms (16 days) were examined. We show that vaccination of male mice decreases the progress of in vitro treatment and the endurance of undeveloped organisms at the blastocyst stage. Openness of proxy moms to the fundamental liquid of inoculated guys not just wipes out the adverse consequence of vaccination on spermatozoa, yet in addition animates the development pace of undeveloped organisms because of the upgraded conveyance of maternal assets. These outcomes highlight potential situations for the effect of antigen challenge on male conceptive capability, including inoculation or viral diseases.

Author(s) Details:

G. V. Kontsevaya,
Federal Research Center Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.

L. A. Gerlinskaya,
Federal Research Center Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.

Y. M. Moshkin,
Federal Research Center Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.

M. V. Anisimova,
Federal Research Center Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.

A. K. Stanova,
Federal Research Center Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.

T. I. Babochkina,
Federal Research Center Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.

M. P. Moshkin,
Federal Research Center Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia and  Tomsk State University, Tomsk, Russia.

Please see the link here: https://stm.bookpi.org/RABS-V6/article/view/7912