Determination of Hyperuricemia and its Associated Cardiovascular Risk Factors among Adult Yemeni People in Sana’a City, Yemen | Chapter 12 | Advancement and New Understanding in Medical Science Vol. 8

 This chapter aimed to investigate the prevalence of hyperuricemia in sample of Yemeni adult individual and its relationship to certain cardiovascular risk factors namely obesity, hypertension, serum glucose, total cholesterol, high serum triglyceride, Low High Density Lipoprotein (HDL-C) and high Low Density Lipoprotein (LDL-C). Hyperurecemia is metabolic problem that has become increasingly worldwide over the past several decades and it's the most risk factor for gout. Over the past few decades, hyperuricemia-a metabolic condition-has become more prevalent all over the world. It is more common in both developed and developing nations, such as Yemen. This was across sectional population based study conducted in Sana'a city for a period of 16 months from April 2017 to August 2018, a sample of 600 adult Yemeni people (275 male and 325 female aged ≥ 18 years) was randomly selected from those attending Al-Kuwait University Hospital and Consultation Clinic. All the study groups undergo full clinical history and examination includes measurement of BP and BMI, WC and the following laboratory investigation (FBS, Basal serum uric acid level, total cholesterol, serum TG, HDL and LDL).

The prevalence of hyperuricemia in this study was 8.8% (11.6% male and 6.4% female). The serum uric acid level in this study was significantly correlated with age, Waist Circumference (WC), SBP, DBP, FBS, T-cholesterol, TG and LDL but not with HDL. Elevation of the serum uric acid level has been known associated with major cardiovascular risk factors, such as hypertension, insulin resistance, dyslipidemia and obesity, which are hallmarks of metabolic syndrome. Furthermore, methods for the early identification, management, and prevention of hyperurecemia are desperately needed since they may help lower the risk of serious side effects such chronic kidney disease and cardiovascular disease.

Author(s) Details:

Mohammed Ahmed Bamashmos,
Internal Medicine and Endocrinology, Sana'a University, Yemen.

Khaled Al-Aghbar,
Internal Medicine and Endocrinology, Sana'a University, Yemen.

Please see the link here: https://stm.bookpi.org/ANUMS-V8/article/view/13524

Prescribing Pattern of Antidiabetic Drugs amongst Pre-obese Diabetic Patients in a Tertiary Care Hospital, India | Chapter 14 | Issues and Development in Health Research Vol. 6

Background: In order to improve prescription quality and promote logical prescribing patterns, it is unavoidable to look into the elements that influence doctors' prescribing habits. Prescribers can benefit from feedback on drug prescription and consumption patterns in order to enhance their prescribing behaviour. Diabetes is a non-communicable disease that affects many people. Due to the condition and its various complications, such as CAD, hypertension, renal difficulties, retinal damage, neurological abnormalities, and generalised infections, it has a significant morbidity and mortality rate. The treatment is customised and neither full nor satisfying, given the multifactorial background of high prevalence, progressive nature of the disease, and availability of many therapeutic regimens offered on a trial and error basis.

The goal of this study was to examine the present prescribing pattern in pre-obese type 2 diabetes mellitus patients in terms of drug/drugs per prescription, dose, treatment duration, and frequency of drug changes.

Methods: Between 2014 and 2016, a prospective, parallel group, comparative observational study was conducted in the department of pharmacology and endocrinology at KIMS Bhubaneswar. The pre-obese individuals were separated into two groups: a) new diabetics and b) old diabetics (3 years). a)Monotherapy-Metforminb)Combination therapy-Metformin+another antidiabetic group, especially sulfonylureas, alphaglucosidase inhibitors, or DPP 4 inhibitors c)Triple therapy(Metformin+SU+Voglibose or Gliptins or Glitazones) d)Insulin with additional oral hypoglycemic medicines

The majority of prescriptions in this tertiary care hospital were determined to be in compliance with the ADA criteria, according to the results of the prescribing pattern analysis. As a first-line treatment, metformin monotherapy was prescribed. Sulphonylureas/Gliptins/Alpha glucosidase inhibitors/thiazolidinediones were utilised as a second-line therapy or as monotherapy, depending on the patient's needs, tolerance, and cost.

Conclusions: The anti-diabetic drugs provided at this hospital were determined to be compliant with the American Diabetes Association's (ADA) guidelines.

Author(S) Details

Sougata Sarkar
Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, India.

Vartika Srivastava
2Department of Pharmacology, Kalinga Institute of Medical Sciences, Bhubaneswar, India.

Adrija Roy
Community Medicine, KIMS, Bhubaneswar, India.

Manjushree Mohanty
Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.

View Book:- https://stm.bookpi.org/IDHR-V6/article/view/4254