Diels-Alder (DA) reactions typically yield heterocyclic six-membered ring compounds via a [4π+2π] cycloaddition of a diene (such as furan or cyclopentadiene) and a dienophile. The choice of solvent and catalyst is critical in affecting the yield and stereoselectivity of the reaction. Cyclodextrins, particularly beta-cyclodextrin (β-CD) and its derivatives, are commonly used as catalysts in aqueous medium due to their ability to form a favorable ternary complex with both the diene and dienophile. As a result, this paper summarizes several experimental studies on the catalytic effects of CDs on DA reactions, with an emphasis on yields, reaction durations, quantities, and selectivity. The first phase, reported by Ronald Breslow and colleagues in 1980, looked at the effect of inner cavity size on catalytic and inhibitory effects on DA processes. The following phase investigated the effect of cyclodextrin catalysts on endo- and stereoselectivity. Numerous studies have examined the potential of β-CD's interior size, derivatives, amounts, organic and aqueous media, and compatibility with the two reagents. In contrast, some research has concentrated on employing cyclodextrins as catalysts in Diels-Alder processes to generate large yields of bioactive chemicals and polymer synthesis under mild conditions, generally in aqueous solutions.
Author
(s) Details
Amine Ez-zoubi
Laboratory of Applied Organic Chemistry, Faculty of Sciences and
Techniques, Sidi Mohamed Ben Abdellah University, Route d’Imouzzer, Fez,
Morocco.
Soukaina Benkirane
Laboratory of Applied Organic Chemistry, Faculty of Sciences and
Techniques, Sidi Mohamed Ben Abdellah University, Route d’Imouzzer, Fez,
Morocco.
Ayoub El-Mrabet
Laboratory of Applied Organic Chemistry, Faculty of Sciences and
Techniques, Sidi Mohamed Ben Abdellah University, Route d’Imouzzer, Fez,
Morocco.
Mouad Mouhsin
Laboratory of Engineering in Chemistry and Physics of Matter, Faculty of
Science and Technologies, Sultan Moulay Slimane University, BP 523, Beni
Mellal, Morocco.
Riham Sghyar
Laboratory of Applied Organic Chemistry, Faculty of Sciences and
Techniques, Sidi Mohamed Ben Abdellah University, Route d’Imouzzer, Fez,
Morocco and Equipe de Chimie Organique Appliquée à la valorisation des
Ressources Naturelles et Protection de l’Environnement, Laboratoire de Chimie
et Microbiologie Appliquées et Biotechnologies, FS, Abdelmalek Essaadi
University Tetouan, Morocco.
Abdellatif Alami
Laboratory of Applied Organic Chemistry, Faculty of Sciences and
Techniques, Sidi Mohamed Ben Abdellah University, Route d’Imouzzer, Fez,
Morocco.
Chandrakant Sarode
Department of Chemistry, Bhusawal Arts, Science and P.O. Nahata Commerce
College, Bhusawal, affiliated to KBC North Maharashtra University, Jalgaon,
425001, India.
Gaurav Gupta
Department of Chemistry, NTVS’s G.T.P. Arts, Commerce and Science College,
Nandurbar, affiliated to KBC-North
Maharashtra University, Jalgaon, 425001, India.
Abdellah Farah
Laboratory of Applied Organic Chemistry, Faculty of Sciences and
Techniques, Sidi Mohamed Ben Abdellah University, Route d’Imouzzer, Fez,
Morocco.
Please see the book here:- https://doi.org/10.9734/bpi/cmsrf/v2/4904
