Studies on Compatibilty of Rivaroxaban with Pharmaceutical Excipients Using DSC and FTIR Spectrophotometry | Chapter 10 | Challenges and Advances in Pharmaceutical Research Vol. 4

A potent oral anticoagulant, rivaroxaban (RN), was just recently created. It was the medication that was most frequently administered during the COVID-19 epidemic. This study aims to explore the compatibility of rivaroxaban with crospovidone, sodium starch glycolate, magnesium stearate, talc, microcrystalline cellulose, aerosil, HPMC K100 M, and croscarmellose sodium using a differential scanning calorimeter and an FTIR spectrophotometer. According to DSC thermograms of rivaroxaban and a physical combination of several pharmaceutical excipients, the drug transition temperature ranged from 224°C to 232°C. The FTIR plots showed that all of the chosen pharmaceutical excipients had wave numbers that matched to rivaroxaban. The DSC and FTIR analyses revealed that RN was not interfering with the selected pharmaceutical excipients and that it may be employed in future studies. According to the investigation's findings, these combinations are safe and can be employed in future research to create rivaroxaban-containing pharmaceutical formulations.

Author (s) Details:

Rama Rao Nadendla,
Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur, Andhra Pradesh, India.

J. Satynarayana,
Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur, Andhra Pradesh, India.

Jaya Krishna Burri,
Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur, Andhra Pradesh, India.

Please see the link here: https://stm.bookpi.org/CAPR-V4/article/view/7512

Effect of Thermal Cycle on the Relative Variations of Thermal Properties and Crystalinity of (PP/EPR)/CaCO3 Mixtures | Chapter 8 | Research Aspects in Chemical and Materials Sciences Vol. 1

 The goal of this chapter is to look at how the constants of thermal properties and the degree of crystallinity of mixes (PP/EPR)/Calcium carbonates prepared using the Micro Bivis vary over time. Three calcium carbonate models were utilised to strengthen the basic copolymer PP/EPR at a low level: socal312, socal322v, and Winnofil spm (5 percent ). Using differential scanning calorimetry DSC, the various combinations were then subjected to two cycles of thermal loading. Finally, we determined the degree of crystallinity of the mixes using the thermal characteristics of isotactic polypropylene (TfP, TcP, HfP, HcP). One of the project's objectives is to reduce the energy cost of mixing mixes. The relative differences between the aforementioned characteristics and those of the basic copolymer were measured. It shows that when calcium carbonate loading is modest, the enthalpies of crystallisation during the second exothermic cycle fall, with values as high as 5,53 J/gPP for the basic copolymer PP/EPR. During the second endothermic cycle, the melting temperatures of isotactic polypropylene for all blends, as well as the basic copolymer PP/EPR, rise. Calcium carbonates have been demonstrated to lower the melting energy of isotactic polypropylene even at a low loading rate for the majority. The existence of a so-called limited amorphous phase in our composites enhances this phenomena, which is connected to the number of endothermic cycles.

Author(s) Details:

Noah Pierre Marcel Anicet,
Laboratory of Mechanics, ENSET, University of Douala, P.O. Box 1872, Douala, Camroon and Department of Mechanical Engineering, ENSET, University of Douala, P.O. Box 1872, Douala, Cameroon.

Ayissi Zacharie Merlin,
Laboratory of Energy Materials Modelisation and Method, University of Douala, Douala, Cameroon.

Zogo Tsala Simon Armand,
Department of Civil Engineering, ENSET, University of Ebolowa, P.O. Box 886, Ebolowa, Cameroon.

Kenmogne Fabien,
Department of Civil Engineering, ENSET, University of Douala, P.O. Box 1872, Douala, Cameroon.

Betene Ebanda Fabien,
Laboratory of Mechanics, ENSET, University of Douala, P.O. Box 1872, Douala, Cameroon and Department of Mechanical Engineering, ENSET, University of Douala, P.O. Box 1872, Douala, Cameroon.

Atangana Ateba,
Laboratory of Mechanics, ENSET, University of Douala, P.O. Box 1872, Douala, Cameroon and Department of Mechanical Engineering, ENSET, University of Douala, P.O. Box 1872, Douala, Cameroon.

Please see the link here: https://stm.bookpi.org/RACMS-V1/article/view/7102

Structural Changes in UHMWPE Reactor Powders during Sintering under Different Conditions| Chapter 9 | New Trends in Physical Science Research Vol.3

The change in the structure of the ultra-high-molecular-weight polyethylene (UHMWPE) nascent reactor powder during sintering at various temperatures and pressures was examined using the DSC method to elucidate the effect of processing parameters on the structure. Scanning electron microscopy revealed that the primary morphological units of the UHMWPE reactor powder investigated are crystalline lamellae. Because the heat flux dH/dT (where H is the melting enthalpy and T is the sample temperature) is proportional to the mass fraction of lamellae melting at a given temperature, data on the thickness distribution of the lamellae could be obtained by analysing the shape of the polymer melting peak on the DSC curves. The structure of UHMWPE has not yet been subjected to such scrutiny. The proportion of thick (>15 nm) and thin (10 nm) lamellae in compacted samples and those sintered at a temperature of 130oC (lower than the equilibrium melting temperature of an infinitely long polyethylene crystal T0 = 142oC) is found to be virtually identical. Significant variations in the composition of the lamellae of various thicknesses have been observed in the samples sintered at temperatures above the T0 of PE with subsequent cooling under various circumstances. At the same time, their melting points remained unaltered when the samples were heated from 130°C to 145°C while under pressure.

Author(s) Details:

L. P. Myasnikova,
IOFFE Institute, 26 Polytechnicheskaya, St. Petersburg 194021, Russia.

A. K. Borisov,
IOFFE Institute, 26 Polytechnicheskaya, St. Petersburg 194021, Russia.

Yu. M. Boiko,
IOFFE Institute, 26 Polytechnicheskaya, St. Petersburg 194021, Russia.

A. P. Borsenko,
A. A.Galkin Physical-Technical Institute, str. R. Luxemburg 72, Donetsk, 83114, Ukraine.

V. F. Drobot’ko,
A. A.Galkin Physical-Technical Institute, str. R. Luxemburg 72, Donetsk, 83114, Ukraine.

V. M. Egorov,
IOFFE Institute, 26 Polytechnicheskaya, St. Petersburg 194021, Russia.

E. M. Ivankova,
Institute of Macromolecular Compounds, 31 Bolshoy pr., St. Petersburg 199004, Russia.

E. I. Radovanova,
IOFFE Institute, 26 Polytechnicheskaya, St. Petersburg 194021, Russia.

V. A. Marikhin,
IOFFE Institute, 26 Polytechnicheskaya, St. Petersburg 194021, Russia.

Please see the link here: https://stm.bookpi.org/NTPSR-V3/article/view/6828