Dental pulp tissue exposed to mechanical trauma or
cariogenic processes can result in infection of the root canal system and/or
periapical tissues. Such endodontic infections are common and can be treated
with root canal treatment. Successful disinfection and complete tissue
regeneration are key goals in regenerative endodontics. Despite reported
clinical successes, current regenerative endodontic procedures (REP) face
limitations. To address these, a novel antibiotic and nitric oxide (NO)
releasing biomimetic nanomatrix gel was developed and evaluated for its
antibacterial efficacy against multispecies endodontic bacteria and animal
models.
The gel, synthesized from peptide amphiphiles, encapsulated
ciprofloxacin (CF) and metronidazole (MN) alongside NO. Antibacterial effects
were assessed using bacterial viability assays on endodontic microorganisms,
including clinical samples. Additionally, pulp-dentin regeneration was
evaluated in the beagle’s tooth model.
Results demonstrated that the antibiotics and NO-releasing
biomimetic nanomatrix gel had a concentration-dependent antibacterial effect,
with NO alone also showing significant efficacy. In vivo studies further
indicated that the gel promoted tooth revascularization and root canal
maturation.
This research suggests that the optimal concentration of the
NO-releasing nanomatrix gel holds promise as a root treatment material for REP.
Future studies will focus on refining growth factor incorporation and
conducting larger-scale trials to confirm its efficacy and establish protocols
for human clinical application.
Author(s)details:-
Chan-Yang Moon
Department of Pediatric Dentistry, Kyung Hee University, Seoul, Korea.
Ok Hyung Nam
Department of Pediatric Dentistry, Kyung Hee University, Seoul, Korea.
Misun Kim
Department of Pediatric Dentistry, Kyung Hee University, Seoul, Korea.
Hyo-Seol Lee
Department of Pediatric Dentistry, Kyung Hee University, Seoul, Korea.
Sagar N. Kaushik
Department of Biomedical Engineering, University of Alabama at Birmingham,
Birmingham, Alabama, United States of America.
David A. Cruz Walma
Department of Pediatric Dentistry, University of Alabama at Birmingham,
Birmingham, Alabama, United States of America.
Ho-Wook Jun
Department of Biomedical Engineering, University of Alabama at Birmingham,
Birmingham, Alabama, United States of America.
Kyounga Cheon
Department of Pediatric Dentistry, University of Alabama at Birmingham,
Birmingham, Alabama, United States of America.
Sung Chul Choi
Department of Pediatric Dentistry, Kyung Hee University, Seoul, Korea.
Please See the book
here :- https://doi.org/10.9734/bpi/acmms/v5/3156
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