Urinary Tract Infection (UTI) occurs more in women than men.
Escherichia coli are responsible in most cases. The microbial (Lactobacillus)
species which inhabit in the vaginal tract play an important role in the
prevention of infection. Irrational use of antibiotics contributes to changes
in antibiotic susceptibility patterns of pathogens. Hence, the administration
of probiotics exogenously may cause colonization of Lactobacillus in female
urogenital organs. The study aimed to assess the effectiveness of probiotics in
the treatment of UTI among women in Bangladesh. This interventional,
prospective, non-randomized trial was conducted among women suffering from UTI
in the department of Pharmacology and Gynecology of Uttara Adhunik Medical
College Hospital, Bangladesh from January 2019 to June 2021. A total of 162
women who suffered from UTI were enrolled to receive probiotic, antibiotic and
probiotic+antibiotic treatments. Urine culture and sensitivity tests of all
participants were done during enrollment. Patients came for follow-up visits on
day 30 of completion of therapy and the final study population was 132. Among
the 132 participants, the mean ages were 34.23 ± 14.28 years (mean ± SD). The
average duration of UTI prior to enrollment was 77.61 ± 288.59 days. 93.18% of
patients complained burning sensation of urination, pain or pressure in the
back or lower abdomen (67.42%) and fever (37.12%), respectively. During
enrollment, the urine R/M/E test revealed that most of the urine samples showed
no growth of organisms (84.8%) and E. coli (09.85%). The most commonly used
antibiotic was nitrofurantoin (43.33%), cefixime (18.88%) and ciprofloxacin
(18.88%). During follow-up, urine sample culture revealed no growth of
pathogenic organisms in 131 (99.24%) and E. coli in one patient who was treated
with only probiotics. The present study revealed that the use of probiotics is
effective and safe in treating UTIs in women in Bangladesh.
Author(s)details:-
Fatima Farhana
Department of Pharmacology, Uttara Adhunik Medical College, Uttara, Dhaka,
Bangladesh and Department of Public Health and Informatics, Jahangirnagar
University, Savar, Dhaka, Bangladesh.
Nafisa Mosaddek
Department of Environmental Science, Bangladesh University of
Professionals, Mirpur, Dhaka, Bangladesh.
Abu Syed Md. Mosaddek
Department of Pharmacology, Uttara Adhunik Medical College, Uttara, Dhaka,
Bangladesh and Department of Biomedical Research, Uttara Adhunik Medical
College, Uttara, Dhaka, Bangladesh.
Md. Saiful Islam
Department of Public Health and Informatics, Jahangirnagar University,
Savar, Dhaka, Bangladesh.
Nazmul Hossain
Department of Electrical and Computer Engineering, North South University,
Dhaka, Bangladesh.
Anima Sarker
Department of Gynecology, Uttara Adhunik Medical College, Uttara, Dhaka,
Bangladesh.
Taposhi Rabeya Mukta
Department of Pharmacy, South East University, Banani, Dhaka, Bangladesh.
Rumi Akter
Department of Pharmacy, South East University, Banani, Dhaka, Bangladesh.
Rinat Rizvi
Department of Healthcare, Uttara Adhunik Medical College, Uttara, Dhaka,
Bangladesh.
Hasan K. M. R.
Department of Public Health and Informatics, Jahangirnagar University,
Savar, Dhaka, Bangladesh.
Ansary E.A. F.
Department of Nephrology, Uttara Adhunik Medical College, Uttara, Dhaka,
Bangladesh.
Hrishik Iqbal
Department of Mathematics and Natural Sciences, Brac University, Dhaka,
Bangladesh.
Please See the book
here :- https://doi.org/10.9734/bpi/mria/v3/181
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