RNA polymerases belong to a selected group of evolutionarily
conserved proteins. Their role emerged with the coming of DNA molecules having
more stability than the RNA molecules, which formed the RNA world before it.
The chapter makes a detour through RNA polymerases working in a eukaryotic
system and their prokaryotic counterpart—a special emphasis on their structural
aspect and functional variation arising due to variation in structure. Further,
the importance of various known transcription factors has been explained along
with accessory transcription factors that serve as an essential regulator of
RNAP activity. A mutation occurring in these proteins results in the aberration
of polymerase activity that results in a plethora of diseases ranging from the
developmental disorder, autoimmune diseases to cancers.
Author(s) Details Vivek Pandey
South Asian University, New Delhi 110021, India.
Dr. Yuba Raj Pokharel
South Asian University, New Delhi 110021, India.
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/206
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