As reconstructive transplantation is gaining popularity as a
viable alternative for upper limb amputees, it is becoming increasingly
important for plastic surgeons to renew surgical skills and knowledge of this
area. Forelimb allotransplantation research has been performed previously in
rodent and swine models. However, preclinical canine forelimb
allotransplantation studies are lacking in the literature. The purpose of this
paper is to provide an overview of the surgical skills necessary to
successfully perform forelimb transplantation in canines as ameans to prepare
for clinical application. A total of 18 transplantation operations on canines
were performed. The recipient limb was shortened at the onethird proximal
forearm level. The operation was performed in the following order: bones (two
reconstructive plates), muscles and tendons (separately sutured), nerves
(median, ulnar, and radial nerve), arteries (two), and veins (two). The total
mean time of transplantation was 5 hours ± 30 minutes. All of the animals that
received transplantation were treated with FK-506 (tacrolimus, 2 mg/kg) for 7
days after surgery. Most allografts survived with perfect viability without
vascular problems during the early postoperative period. The canine forelimb
allotransplantation model is well qualified to be a suitable training model for
standard transplantation and future research work.
Author(s) Details Seokchan Eun
Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seoul 463-706, Republic of Korea.
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