A Wee Study on Behavioural, Organ Somatic Index and Histological Alterations of the Fresh Water Fish Pangasius sutchi in Response to Protection Studies, Exposed to Gamma Radiation Perceived by Genotoxic Assays: New Perspectives | Chapter 13 | Trends in Pharmaceutical Research and Development Vol.2

The aim of the present study was to evaluate radio-protective effect of Gymnema sylvestre and its active compound gymnemagenin against gamma radiation(60Co) in Pangasius sutchi. The fishes were treated with lowest concentration of amifostine (83.3 mg/kg of b.wt.), G. sylvestre plant-extract (25 mg/kg of b.wt.), and gymnemagenin (0.3 mg/kg of b.wt.) as intramuscular injection one hour prior to exposure of gamma radiation. The result revealed destructive histological alteration of irradiated fishes compared to pre-treatment group of amifostine, G. sylvestre, and gymnemagenin. Similarly, behavioural changes and organ somatic index also showed variations among the irradiated and pretreatment groups which might reflect metabolic and physiologic disturbances under the effect of radiation. The pre-treatment of G. sylvestre showed similar result as compared to amifostine which indicates the existence of radio-protective properties in the plant.  

Author(s) Details

Dr. Pamela Sinha,
Vanta Bioscience Limited SIPCOT Industrial complex, Gummidipoondi, Tamil Nadu – 601201, India.

Dr. Kantha D. Arunachalam
Center for Environmental Nuclear Research, SRM Institute of Science and Technology, SRM Nagar, Potheri, Chennai- 603203, India.

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