The
concept of sequential cytotoxicity indicates the successive release of two or
more cytotoxic compounds causing grater toxicity to the neoplasm than normal
cell. This hypothesis is evaluated by designing a series of compounds of 2, 6
diphenyl piperidine-4-one. Recently for the development of novel cytotoxic and
anticancer agents, different series of compounds have been designed that
utilizes the 1, 5-diaryl-3-oxo-1, 4-pentadinyel pharmacophore. These compounds
interact with cellular thiols of cell and thiols are not part of nucleic acids.
Hence these compounds are free from the problem of mutagenicity and
carcinogenicity. The series of compounds which either lacking of olefinic bond
or one or more olefinic bond are synthesized by Claisen-Schmith reaction. The
compounds having one or no any olefinic bonds will be predicted to be less
cytotoxic than the compounds having two or three olefinic bonds. The SRB-assay
method was used to evaluate cytotoxic property of all the synthesized
compounds. The results revealed that the predictions made regarding the
viability of the theory of sequential cytotoxicity were fulfilled.
Author(s) Details
Dr. Rahul L. Jadhav
Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, India.
Dr. Chandrakant S. Magdum
K. E. Society’s Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, India.
Miss. Manisha V. Patil
Adarsh College of Pharmacy, Vita, Sangli, Maharashtra, India.
View Book: - http://bp.bookpi.org/index.php/bpi/catalog/book/173
Author(s) Details
Dr. Rahul L. Jadhav
Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, India.
Dr. Chandrakant S. Magdum
K. E. Society’s Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, India.
Miss. Manisha V. Patil
Adarsh College of Pharmacy, Vita, Sangli, Maharashtra, India.
View Book: - http://bp.bookpi.org/index.php/bpi/catalog/book/173
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