Hypertensive disorders of pregnancy (which include
pre-eclampsia) are one of the most common causes of death due to pregnancy.
Pre-eclampsia is defined as hypertension (systolic blood pressure>140 mmHg,
diastolic blood pressure >90 mmHg) after gestation of 24 weeks along with
proteinuria (urine protein concentration >300 mg in 24 h sample.
Pre-eclampsia increases the risk of poor outcomes for both the mother and the
baby. If left untreated, it may result in seizures at which point it is known
as eclampsia. During acute ischemic conditions, the metal‐binding capacity of
albumin to transition metals such as copper, nickel, and cobalt is reduced,
leading to the generation of a metabolic variant of the protein, commonly known
as ischemia‐modified albumin (IMA). Preeclampsia is characterized by poor
placental perfusion due to vasospasm of uterine spiral arteries. It is
associated with ischemia and increased oxidative stress, which may lead to
modification of plasma albumin to ischemia modified albumin. IMA measurement
has recently been proposed as a sensitive marker for the diagnosis of
myocardial ischemia but it has been reported to be associated with other
conditions also where ischemia is involved. Reports on estimation of cord blood
IMA in preeclampsia are quite sparse and this chapter aims to analyze the role
of IMA in cord blood of preeclamptic patients.
Author(s) Details
Kiran Dahiya Author(s) Details
Department of Biochemistry, Pt. BD Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.
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