Chemistry of Depsides from Manglicolous lichen Dirinaria consimilis (Stirton) D.D. Awasthi along with their Pharmacological Insights | Chapter 1 | Innovations in Biological Science Vol. 4

 

This book chapter provides a thorough examination of the isolation process, structural characterization, and pharmacological properties of two novel depsides, Antarvedisides A and B, extracted from Dirinaria consimilis (Stirton) D.D. Awasthi, alongside several known depsides. The study explores the compounds' structural features and delves into their pharmacological profile, emphasizing their potential as promising candidates for future drug development. Chromatographic examination of acetone extract of D. consimilis yielded Antarvedisides A and B, sekikaic acid, atranorin, divaricatic acid and 2’-O-methyl divaricatic acid. Antioxidant activity assessment through superoxide, DPPH and ABTS radical scavenging assays reveals that Antarvedisides A-B and 2’-O-Methyldivaricatic acid exhibit remarkable antiradical scavenging capacities, surpassing the standard drug, ascorbic acid. The investigation extends to in vitro anti-inflammatory activity, where atranorin exhibits superior inhibition against protein denaturation in comparison to the standard drug indomethacin. Antarvedisides A-B showcases moderate anti-inflammatory activity, further detailed with IC50 values ranging from 878-600 µg/mL. The anticancer potential of the depsides is highlighted through the Sulforhodamine B assay screening. Antarvediside B emerges as a potent inhibitor of cell growth in MCF-7 and HeLa, outperforming doxorubicin. Additionally, 2’-O-methyldivaricatic acid demonstrates significant inhibitory profiles against various cancer cell lines. In conclusion, this abstract summarizes the comprehensive pharmacological profile of Antarvedisides A and B, shedding light on their antioxidant, anti-inflammatory, and anticancer activities. These findings underscore the potential of these depsides as valuable candidates for further drug development and contribute to the expanding knowledge of natural compounds with therapeutic implications.

 

 

Author(s) Details

Vinay Bharadwaj Tatipamula

Pharmaceutical Chemistry Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – 530003, Andhra Pradesh, India.

Girija Sastry Vedula

Pharmaceutical Chemistry Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – 530003, Andhra Pradesh, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v3/12824F

Chemistry of Depsides from Manglicolous lichen Dirinaria consimilis (Stirton) D.D. Awasthi along with their Pharmacological Insights | Chapter 1 | Recent Developments in Chemistry and Biochemistry Research Vol. 3

This book chapter provides a thorough examination of the isolation process, structural characterization, and pharmacological properties of two novel depsides, Antarvedisides A and B, extracted from Dirinaria consimilis (Stirton) D.D. Awasthi, alongside several known depsides. The study explores the compounds' structural features and delves into their pharmacological profile, emphasizing their potential as promising candidates for future drug development. Chromatographic examination of acetone extract of D. consimilis yielded Antarvedisides A and B, sekikaic acid, atranorin, divaricatic acid and 2’-O-methyl divaricatic acid. Antioxidant activity assessment through superoxide, DPPH and ABTS radical scavenging assays reveals that Antarvedisides A-B and 2’-O-Methyldivaricatic acid exhibit remarkable antiradical scavenging capacities, surpassing the standard drug, ascorbic acid. The investigation extends to in vitro anti-inflammatory activity, where atranorin exhibits superior inhibition against protein denaturation in comparison to the standard drug indomethacin. Antarvedisides A-B showcases moderate anti-inflammatory activity, further detailed with IC50 values ranging from 878-600 µg/mL. The anticancer potential of the depsides is highlighted through the Sulforhodamine B assay screening. Antarvediside B emerges as a potent inhibitor of cell growth in MCF-7 and HeLa, outperforming doxorubicin. Additionally, 2’-O-methyldivaricatic acid demonstrates significant inhibitory profiles against various cancer cell lines. In conclusion, this abstract summarizes the comprehensive pharmacological profile of Antarvedisides A and B, shedding light on their antioxidant, anti-inflammatory, and anticancer activities. These findings underscore the potential of these depsides as valuable candidates for further drug development and contribute to the expanding knowledge of natural compounds with therapeutic implications.

Author(s) Details:

Vinay Bharadwaj Tatipamula,
Pharmaceutical Chemistry Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – 530003, Andhra Pradesh, India.

Girija Sastry Vedula
Pharmaceutical Chemistry Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – 530003, Andhra Pradesh, India.


Please see the link here: https://doi.org/10.9734/bpi/rdcbr/v3/12824F

A Recent Update on the Pharmacological Properties, Biosynthesis, Bioavailability, and Toxicological Effects of Zerumbone | Chapter 4 | Research Advances in Microbiology and Biotechnology Vol. 9

 Zerumbone, a monocyclic sesquiterpene is a natural bioactive compound mostly found in the members of the family Zingiberaceae. It is commonly isolated from Zingiber zerumbet, a medicinal plant that has been used traditionally in treatment of different ailments like osteoarthritis, obesity, diabetes, diabetic nephropathy, diabetic retinopathy, gastritis, neuropathic pain, and atherosclerosis. Further, it has been identified to have different pharmacological properties such as anti-inflammatory, anti-cancer, anti-diabetic, antioxidant, anti-microbial, anti-hypersensitivity, chemotherapeutic activities, etc. The present study provides an updated overview of zerumbone with respect to its natural biosynthesis, natural plant sources, and pharmacological and toxicological effects of zerumbone. The present study will help in further research of this compound related to its different pharmacological properties.

Author(s) Details:

Sanasam Thoibi Devi,
Manipur University, Canchipur, Imphal-795003, Manipur, India.

Keithellakpam Sanatombi,
Manipur University, Canchipur, Imphal-795003, Manipur, India.

Please see the link here: https://stm.bookpi.org/RAMB/article/view/12955

Pharmacological Properties of Citrullus lanatus| Chapter 2 | Perspective of Recent Advances in Medical Research Vol. 6

 In view of behavior that we are thriving in, has likely make even incalculable forms of diseases that inquire healing assistance by way of exercise of artificial drugs, resulting in sure reactions. These belongings can be crushed by utilizing natural production as cure. There lives a diverse range of vegetation that retains curative principles and is majorly used by us in the form of meal. One of specific important fruit crop is Citrullus lanatus that is popular for its huge healing and pharmacological possessions. The present chapter supplies the superior features of every unspecified Citrullus lanatus that have happened accomplished earlier. The idea of utilizing natural production over artificial one is due to their less or no reactions, cost-influence and smooth availability. Presence of various phytoconstituents to a degree alkaloids, flavonoids, tannins, amino acids, carbohydrates, glycosides, terpenoids, steroids, carotenoids, oils and fats maybe efficiently promoted in the treatment of miscellaneous types of ailments in the way that cardiovascular, neuro-degenerative, diabetes, unproductiveness, abscess etc. Further, the nutrients present in miscellaneous parts of Citrullus lanatus source of nourishment C, mineral, proteins, glycoprotein, and carbohydrates may be secondhand as supplement against miscellaneous fitness related issues. The objective of the branch is then to provide combined and real informations regarding the pharmacological possessions of Citrullus lanatus established exploratory studies reported up until now. This stage has existed formulated later using up several research items, reviews, book chapters etc. that are arranged in manifestos namely google philosopher, scopus, DOI and Elsevier.

Author(s) Details:

Karuna Gautam,
Zoology Section, MMV, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India.

Sandeep Kumar,
Zoology Section, MMV, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India.

Sarika Srivastava,
Zoology Section, MMV, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India.

Poonam Singh,
Zoology Section, MMV, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India.

Please see the link here: https://stm.bookpi.org/PRAMR-V6/article/view/9147

Determining the Synthesis, Chemical Modification and Biological Properties of N-acylphenothiazines | Chapter 09 | Current Topics on Chemistry and Biochemistry Vol. 1

 This review organised theoretical and experimental data on the many methodologies for the synthesis of N-acylphenothiazines. The goal of this study was to synthesise all of the literature published in the last 20 years around the world. This study also looked at the pharmacological effects of these heterocycles as one of the most promising chemotherapeutic targets in modern bioorganic and medicinal chemistry. The great biological potential of these moieties is assumed to be due to the radical quality of the acyl moiety. As a result, the new study will add to the literature and act as a springboard for medicinal chemistry experts to perform additional research on N-acylphenothiazine moieties as possible chemotherapy medicines.

Author(S) Details

Iryna Myrko
Department of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska St.69, Lviv 79010, Ukraine.

Taras Chaban
Department of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska St.69, Lviv 79010, Ukraine.

Yulia Matiichuk
Department of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska St.69, Lviv 79010, Ukraine.

Mohammad Arshad
College of Medicine, Shaqra University, Al-Dawadmi 11911, Saudi Arabia.

Vasyl Matiychuk
Department of Organic Chemistry, Ivan Franko National University of Lviv, Kyryla i Mefodiya St. 6, Lviv 79005, Ukraine.

View Book:- https://stm.bookpi.org/CTCB-V1/article/view/6530