The present study evaluates the prevalence and trends of
Achromobacter xylosoxidans in clinical specimens and the trend in its
sensitivity pattern. Achromobacter xylosoxidans is an emerging nosocomial
pathogen that is commonly found in the environment. It may lead to nosocomial
infections in hospital settings, particularly in the intensive care unit. It is
frequently identified in humidifiers in intensive care units and is also
frequently linked to patients who have several comorbidities and are immunocompromised.
The Retrospective analysis was done of the culture reports positive for
Achromobacter xylosoxidans by VITEK 2 method and its Antimicrobial sensitivity
pattern was analysed from period of September 2021 to February 2023. The
maximum (54.54%) infection was seen in the age group >50 years. The maximum
number (66.2%) of Achromobacter xylosoxidans were isolated from the Suction
tip, followed by blood (8%) and the Tracheal Tip (5%). Surgical ICU contributed
to the maximum number of infections i.e. 40.2%, followed by Respiratory ICU
(22.1%). Maximum sensitivity was seen for Cotrimoxazole and Meropenem (around
80%), followed by Cefoperazone-Sulbactam (74%), Imipenem, Levofloxacin,
Ceftazidime (around 65%). The sensitivity was minimal for Ceftriaxone (0%), Aztreonam
(1.3%), and Gentamicin (5.2%). The most common risk factors/comorbidities
associated with Achromobacter infections was recent ICU admission (87.01%). The
variation in antibiotic sensitivity or resistance can be due to the various
factors like antibiotics used in patients in primary treatment, the immune
status of the patients from which the sample was collected, overuse or misuse
of antibiotics, availability of antibiotics, etc. The antibiotic of choice in
our conclusion is Cotrimoxazole, followed by Piperacillin-Tazobactam. Colistin
should be kept as a reserve drug for the last resort treatment.
Author(s) Details
Malvika Singh
Department of Microbiology, Shri Guru Ram Rai Institute of
Medical and Health Sciences, Dehradun, Uttarakhand, India.
Dimple Raina
Department of Microbiology, Shri Guru Ram Rai Institute of
Medical and Health Sciences, Dehradun, Uttarakhand, India.
Ranjana Rohilla
Department of Microbiology, Shri Guru Ram Rai Institute of
Medical and Health Sciences, Dehradun, Uttarakhand, India.
Himanshu Narula
Department of Microbiology, Shri Guru Ram Rai Institute of
Medical and Health Sciences, Dehradun, Uttarakhand, India.
Ajay Pandita
Department of Community Medicine, Shri Guru Ram Rai
Institute of Medical and Health Sciences, Dehradun, Uttarakhand, India.
Please see the link:- https://doi.org/10.9734/bpi/rpmab/v4/274
