The Pathogenesis of Cutaneous Lupus Erythematosus Revealed through the Therapeutic Effects of Hydroxychloroquine | Chapter 12 | Advancement and New Understanding in Medical Science Vol. 6

In recent years of research in immunology, the understanding of innate immunity has deepened, and the concept of innate immunity has been proposed even in the field of acquired immunity. The conventional immunosuppressive treatments mainly act via regulation of acquired immunity. However, the involvement of innate immunity was confirmed for hydroxychloroquine (HCQ), which has been confirmed to be effective in the treatment of cutaneous lupus erythematosus (CLE). Approximately 1.5 years prior to this trial, HCQ was officially approved for use in Japan by the Japanese Ministry of Health, Labor and Welfare for the treatment of CLE and SLE in September 2015. This review introduces the mechanism underlying the development of CLE from the viewpoint of autoantibodies, cytokines, and innate immunity. Furthermore, the mechanism of action of HCQ is introduced and discussed.

Author(s) Details:

Fukumi Furukawa,
Department of Forensic Medicine, Wakayama Medical University, 811-1 Kimiidera, 641-8509 Wakayama, Japan.

Please see the link here: https://stm.bookpi.org/ANUMS-V6/article/view/13363

The Fooling of Homeostasis Hypothesis Explains All What the Human Papillomavirus Infection does to the Cervix in Woman | Chapter 16 | New Horizons in Medicine and Medical Research Vol. 2

 After Human Papillomavirus infection, the three most prevalent cervix disease states are low-grade squamous intraepithelial lesion, high-grade squamous intraepithelial lesion, and cervical cancer. The goal of this research is to identify a viable cure for cervical cancer by pinpointing the origins of the three disease states of the cervix listed above. The Fooling of Homeostasis Hypothesis was used to explain the origins of all three in this chapter. According to this idea, for malignancies originating from stem cells, the would-be cancer cells undergo aggressive growth and aggressive death (at the same rate), deceiving the homeostasis maintained by the surrounding healthy cells and immune cells. This hypothesis claims that the chemicals ethanol-alcohol dehydrogenase and sodium metabisulphite could be used to treat cervical cancer.

Author(S) Details

Pushpam Kumar Sinha
Independent Researcher, 101, Vijayshree Complex, Kankarbagh, Patna- 800020, India.

View Book:- https://stm.bookpi.org/NHMMR-V2/article/view/6136