Antipyretic Activity Test of Rambutan (Nephelium lappaceum L.) Seed in White Male Mice (Mus musculus) |Chapter 8 | Recent Developments in Chemistry and Biochemistry Research Vol. 5

 

The rambutan plant (Nephelium lappaceum L.) empirically contains flavonoids. Flavonoid has many kinds of bioactivity which function as antipyretic, analgesic, and anti-inflammatory effects and can help reduce fevers. There have not been many studies conducted on rambutan seeds as a pain and fever reliever. Fever is a sign that the body is fighting infection or bacteria in the body, usually, the body temperature has increased greater than normal body temperature (> 37.2oC). The purpose of this study was to prove the antipyretic activity of rambutan seed extract against white male mice induced by the DPT-HB-Hib vaccine. This study used an experimental method which was divided into 5 treatment groups, namely, negative control of 1% Na CMC, positive control of paracetamol 1.3 mg/20 g BW of mice, and three groups of rambutan seed extract doses of 37.5 mg, 75 mg, and 150 mg/20 g BW mice. Fresh rambutan fruit was taken from Cikalang Tengah village, Tawang sub-district, Tasikmalaya City. Temperature measurements were carried out for 180 minutes with 30-minute intervals. The data obtained were analyzed by ANOVA test and LSD test. ANOVA test results for 180 minutes obtained p-value = 0.035, which means that there is a significant difference in temperature reduction in the five treatment groups, while the LSD test results for 180 minutes, the most effective dose is dose II of 75 mg/20 g BW in mice compared to other doses and did not have a significant difference with the positive control (paracetamol) because it had a comparable effect in reducing fever temperature in mice (Mus musculus). The dose III for 150mg/BW has an effectiveness rate of 98.11%. The highest antipyretic effectiveness falls to dose II for 75 mg/20g BW (98.58%), and the results are statistically significant.

 

Author(s) Details

Nitya Nurul Fadilah
Pharmacy Study Program, Universitas Perjuangan Tasikmalaya, Tasikmalaya, Indonesia.

Ali Nofriyaldi
Pharmacy Study Program, Universitas Perjuangan Tasikmalaya, Tasikmalaya, Indonesia.

Suna Agustine Junaedi
Pharmacy Study Program, Universitas Perjuangan Tasikmalaya, Tasikmalaya, Indonesia.

 

Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v5/1305

Determining the Anthelmintic Activity of Lindernia madayiparense against Indian Earthworms| Chapter 6 | Current Overview on Pharmaceutical Science Vol. 2

 The current study wanted to determine the anthelmintic venture of Lindernia madayiparense against Indian earthworms, Pheretima posthuma. Helminthiasis poses a serious risk to the public's energy and increases the incidence of pneumonia, eosinophilia, chlorosis, and malnutrition in underdeveloped countries. Decoction and continuous hot ancestry methods were used to form various extracts. To recognize the presence of phytochemical constituents, preliminary subjective analysis was acted on all L. madayiparanse extracts. The best anthelmintic activity between the studied extracts against earthworms was demonstrated for one ethanol extract, that was also outside limits other extracts at all concentrations and carefully matched the normal medication, albendazole. A dosage-dependent paralytic effect and organize of death were present effectively of the studied extracts. Certain results led to the theory that the existence of these subordinate metabolites, such as alkaloids, flavonoids, terpenoids, tannins, and saponins, can be the cause of the observed anthelmintic activity.

Author(s) Details:

S. Umakrithika,
GITAM School of Pharmacy, Gandhi Institute of Technology and Management (Deemed to be) University, Hyderabad, Telangana-500046, India.

Kannan Kamarajan,
Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalainagar-608002, Tamil Nadu, India.

Prabal Kumar Manna,
Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalainagar-608002, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/COPS-V2/article/view/9168