Cell Block Preparation as an Important Tool in Addition to the Conventional Cytological Smears | Chapter 7 | Medical Research and Its Applications Vol. 1

 

Background: For the detection of malignancy in the serous fluids of the body, cytological examination of the fluid is very important. It is also of prime importance and seems difficult to differentiate malignant cells from reactive mesothelial cells during fluid cytology. The cell block preparation is a useful and additive diagnostic tool when cellular features in cytology are inconclusive or suspicious. The aim of the study was to assess the utilization of the cell technique as an additional tool along with the conventional smears that we are using in routine practice.

Methods: The present study included 200 cases of effusion fluids, out of which 117 were pleural, 82 were peritoneal and 1 was pericardial from a tertiary care hospital, Vadodara, India. The patient presented with complaints of ascites, pleural effusions or pericardial effusions were included in the study. A total of 200 body (effusion) fluids were examined by the conventional cytological smears as well as by the cell block technique.

Results: Out of 200 cases, there were 110 (55%) males and 90 (45%) were females. The cases of pleural effusion were more common amongst the males i.e. 77 (38.5%) whereas only 40(20%) cases were noted among the female. In our study of 200 cases, the maximum number of cases were inflammatory 177 (88.5%) while malignancy was detected in 27 (11.5%) cases. Pleural effusion cases were the commonest among all the cases followed by peritoneal effusion cases and pericardial effusion cases.

Conclusion: The diagnostic of cancer cell yield increases when we use the cell block preparation method along with the conventional smears because the architectural patterns and cell morphology are very well preserved in cell block as compared to the smears.

 

Author (s) details:-

 

Dr. Devanshi Gosai (Associate Professor)
Department of Pathology, Smt. B. K. Shah Medical Institute & Research Centre, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, India.

 

Please See the book here :- https://doi.org/10.9734/bpi/mria/v1/8409E

Recent Updates in Gynaecologic Cytology with Emphasis on Ancillary Techniques: A Review | Chapter 1 | Current Progress in Medicine and Medical Research Vol. 5

 Background: Cervical malignancy is been the 4th most common malignancy in women from developing countries for the most part in the rural population the one are poor ignorant concerning health care.conventional food smear in spite of a useful screening means, has some limitations like concealing factors and inadequate samples.Aim: The study objective search out 1)study The ancillary methods like , Liquid located cytology, cell block method, immunomarkers in cytology , HPV testing in liquid located cytology and molecular indicators in cervical cytology2) to study their role in improving the demonstrative accuracy of cervical cancer by beating the limitations of conventional food smears.National screening programmes should involve all the screening forms.

Author(s) Details:

N. M. Nandini,

Department of Pathology, JSSAHER, Mysore, India.

Please see the link here: https://stm.bookpi.org/CPMMR-V5/article/view/11381

Cervical Cytology Screening Methods for Cervical Lesions Update| Chapter 11 | Issues and Developments in Medicine and Medical Research Vol.11

 According to globocan 2018 estimates, cervical cancer is the fourth most often diagnosed cancer and the fourth greatest cause of cancer mortality in women, with an anticipated 570,000 diagnoses and 311,000 deaths in 2018. Death rates are also higher in low- and middle-income countries due to poverty, ignorance, and a lack of screening programmes in these countries. The purpose of this article is to provide screening procedures, together with their benefits and drawbacks. Conventional pap smear CPS, liquid based cytology (low cost manual liquid based cytology) LBC, HPV Testing, cellblock CB with immunomarker are some of the screening modalities we use and recommend (visual inspection with acetic acid). VIA All of these methods will aid in the early detection of preneoplastic and neoplastic cervix diseases, lowering mortality and morbidity in low-resource nations.

Author(s) Details:

N. M. Nandini,
Department of Pathology, JSSAHER, Mysore, Karnataka, India.


Nandish S. Manoli,
Oxford Medical College, Karnataka, India.

Please see the link here: https://stm.bookpi.org/IDMMR-V11/article/view/6083

An Advanced Concept in Thyroid Cytology with Special Emphasis on Ancillary Techniques| Chapter 6 | Highlights on Medicine and Medical Science Vol. 10

 Thyroid FNAC (fine needle aspiration cytology) has undergone a paradigm shift in its approach to thyroid lesions. The 2017 Bethesda classification has aided in the reclassification of thyroid disorders. The goal of is to: 1. The purpose of the study was to determine the value of adopting the Bethesda method for reporting on various categories. 2. To investigate the effectiveness of ancillary techniques in the thyroid, mlbc cell block 3. To stress the usage of specific thyroid stains. The classification was attempted to be used with an example in each category. A total of 274 cases were studied at a tertiary referral hospital over the course of a year (2018), from January to December. The majority of instances (246 cases) were non-neoplastic, while neoplastic cases accounted for 28 cases. Other ancillary approaches have been highlighted, such as the use of Agnors, Morphometric, Pattern analysis, Cell block, ICC (immunocytochemistry) and LBC (Liquid based cytology). To emphasise the irutility in surgical management of Thyroid, brief comments of molecular approaches and recent breakthroughs, as well as innovative concepts such as NIFTP, have been highlighted.

Author (S) Details

Dr. Nandini N. Manoli
Department of Pathology, JSS Medical College and Hospital, JSSAHER, India.

Bhavya Kotla
Department of Pathology, JSS Medical College and Hospital, JSSAHER, India.

View Book :- https://stm.bookpi.org/HMMS-V10/article/view/2254