Primary Hyperparathyroidism and Hyperthyroidism Associated with Myotonic Dystrophy: A Review of the Literature | Chapter 15 | New Horizons in Medicine and Medical Research Vol. 9

 Background: Primary hypogonadism, diabetes mellitus, and thyroid and parathyroid dysfunction are all typical endocrine symptoms in myotonic dystrophy (MD).

The goal of this study is to provide a rare case of primary hyperparathyroidism and hyperthyroidism associated with MD, as well as to assess its significance through a literature review.

We describe a 46-year-old mother with a kid who has a family history of MD. She needed a pacemaker after being diagnosed with cardiac arrhythmia. Her eyes were found to have a bilateral cataract. Her complaints were muscle weakness, extensive myalgia, and palpitation. Electromyography revealed myotonic discharges (EMG). Serum calcium was 2.83 mmol/L, serum phosphate was 1.2 mmol/L, parathormone was 362.5 pg/mL, and thyroid stimulating hormone was TSH FT4 21.17 ng/mL, 0.02 mIU/L (normal range: 0.34–5.6 mIU/L), and negative anti-thyroperoxidase antibodies. During a cervical ultrasound, a multinodular goitre was identified. Using 99mTc-MIBI scintigraphy, a lower right parathyroid adenoma was detected. Clinical evidence, family history of MD, EMG data, and endocrine abnormalities all pointed to MD being linked to hyperthyroidism and primary hyperparathyroidism.

Author(S) Details

Yosra Cherif
Department of Endocrinology and Internal Medicine, Tahar Sfar University Hospital of Mahdia, Hiboun District, 5100, Mahdia, Tunisia.

Baha Zantour
Department of Endocrinology and Internal Medicine, Tahar Sfar University Hospital of Mahdia, Hiboun District, 5100, Mahdia, Tunisia.

Wafa Alaya
Department of Endocrinology and Internal Medicine, Tahar Sfar University Hospital of Mahdia, Hiboun District, 5100, Mahdia, Tunisia.

Olfa Berriche
Department of Endocrinology and Internal Medicine, Tahar Sfar University Hospital of Mahdia, Hiboun District, 5100, Mahdia, Tunisia.

Samia Younes
Department of Endocrinology and Internal Medicine, Tahar Sfar University Hospital of Mahdia, Hiboun District, 5100, Mahdia, Tunisia.

Mohamed Habib Sfar
Department of Endocrinology and Internal Medicine, Tahar Sfar University Hospital of Mahdia, Hiboun District, 5100, Mahdia, Tunisia.

View Book:- https://stm.bookpi.org/NHMMR-V9/article/view/6910

A Case Report on Parathyroid Adenoma | Chapter 12 | New Horizons in Medicine and Medical Research Vol. 9

 The endocrine disease primary hyperparathyroidism impacts calcium metabolism. Primary hyperparathyroidism is defined by high serum calcium concentrations, high parathyroid hormone concentrations, or inappropriate parathyroid hormone levels for serum calcium values. Primary hyperparathyroidism affects 2.5 out of every 1000 persons in India. Primary hyperparathyroidism can be caused by a noncancerous parathyroid adenoma, hyperplasia, or, in rare circumstances, parathyroid malignancy. The vast majority of these individuals have few or no symptoms. Clinical circumstances, biochemical and radiological investigations, and histology of the samples can all help to make a correct diagnosis. Minimally invasive parathyroidectomy has replaced traditional bilateral neck exploration as the most common surgical therapy for primary hyperparathyroidism. PTH monitoring is most useful as a complement to preoperative testing.

Author(S) Details

Shehnaz R. Kantharia
Department of ENT, Head and Neck Surgery, Kailash Cancer Hospital, Muni Seva Ashram, Goraj, Baroda, Gujarat, India.

Rajesh A. Kantharia
Department of Head and Neck Onco Surgery, Kailash Cancer Hospital, Muni Seva Ashram, Goraj, Baroda, Gujarat, India.

Pradeep K. Reddy
Department of Head and Neck Onco Surgery, Kailash Cancer Hospital, Muni Seva Ashram, Goraj, Baroda, Gujarat, India.

Yogesh M. Mistry
Department of Pathology, Kailash Cancer Hospital, Muni Seva Ashram, Goraj, Baroda, Gujarat, India.

View Book:- https://stm.bookpi.org/NHMMR-V9/article/view/6907