A Primer to Nutrigenomics | Book Publisher International

Nutrigenomics is an interdisciplinary field that explores the relationship between nutrition and genetics, focusing on how individual genetic variations influence responses to nutrients and dietary patterns. This field combines aspects of molecular biology, genomics, and nutrition to understand how nutrients and bioactive food compounds interact with our genes to affect health outcomes and disease risk. The book "“A Primer to Nutrigenomics” provides an accessible overview of the principles, methodologies, and applications of nutrigenomics, exploring key concepts such as gene-environment interactions, epigenetics, and personalized nutrition. It discusses the role of genetic variation in determining nutrient metabolism, absorption, and utilization, and highlights how understanding these interactions can lead to more effective dietary recommendations tailored to individual genetic profiles. Additionally, the book examines the impact of diet on gene expression and disease prevention, offering insights into the potential of nutrigenomics for advancing personalized medicine, public health, and chronic disease management. Through the integration of cutting-edge research and practical examples, this book serves as a foundational resource for students, professionals, and researchers interested in the evolving field of nutrigenomics.

 

Author (s) Details

Dr. D. Udaya Kumar
Department of Human Genetics, Andhra University, Visakhapatnam, Andhra Pradesh, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-39-6

A Primer to Nutrigenomics | Book Publisher International

Nutrigenomics is an interdisciplinary field that explores the relationship between nutrition and genetics, focusing on how individual genetic variations influence responses to nutrients and dietary patterns. This field combines aspects of molecular biology, genomics, and nutrition to understand how nutrients and bioactive food compounds interact with our genes to affect health outcomes and disease risk. The book "“A Primer to Nutrigenomics” provides an accessible overview of the principles, methodologies, and applications of nutrigenomics, exploring key concepts such as gene-environment interactions, epigenetics, and personalized nutrition. It discusses the role of genetic variation in determining nutrient metabolism, absorption, and utilization, and highlights how understanding these interactions can lead to more effective dietary recommendations tailored to individual genetic profiles. Additionally, the book examines the impact of diet on gene expression and disease prevention, offering insights into the potential of nutrigenomics for advancing personalized medicine, public health, and chronic disease management. Through the integration of cutting-edge research and practical examples, this book serves as a foundational resource for students, professionals, and researchers interested in the evolving field of nutrigenomics.

 

Author (s) Details

Dr. D. Udaya Kumar
Department of Human Genetics, Andhra University, Visakhapatnam, Andhra Pradesh, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-39-6

Exosomes and the Cargo microRNAs in Ischemic Heart Disease |Chapter 1 | Innovations in Medicine and Medical Research Vol. 4

 Background: To cure ischemic diseases, angiogenesis needs to be improved by various strategies in

ischemic area. Considering that microRNA-132 (miR-132) regulates endothelial cell behavior during
angiogenesis and the safe and efficacious delivery of microRNAs in vivo is rarely achieved, an ideal
vehicle for miR-132 delivery could bring the promise for ischemic diseases. As a natural carrier of
biological molecules, exosomes are more and more developed as an ideal vehicle for miRNA transfer.
Meanwhile, mesenchymal stem cells could release large amounts of exosomes. Thus, this study
aimed to investigate whether MSC-derived exosomes can be used for miR-132 delivery in the
treatment of myocardial ischemia.
Methods: MSC-derived exosomes were electroporated with miR-132 mimics and inhibitors. After
electroporation, miR-132 exosomes were labelled with DiI and added to HUVECs. Internalization of
DiI-labelled exosomes was examined by fluorescent microscopy. Expression levels of miR-132 in
exosomes and HUVECs were quantified by real-time PCR. The mRNA levels of miR-132 target gene
RASA1 in HUVECs were quantified by real-time PCR. Luciferase reporter assay was performed to
examine the targeting relationship between miR-132 and RASA1. The effects of miR-132 exosomes
on the angiogenic ability of endothelial cells were evaluated by tube formation assay. Matrigel plug
assay and myocardial infarction model were used to determine whether miR-132 exosomes can
promote angiogenesis in vivo.
Results: miR-132 mimics were effectively electroporated and highly detected in MSC-derived
exosomes. The expression level of miR-132 was high in HUVECs preincubated with miR-132 mimicelectroporated exosomes and low in HUVECs preincubated with miR-132 inhibitor-electroporated
exosomes. The expression level of RASA1, miR-132 target gene, was reversely correlated with miR-
132 expression in HUVECs pretreated with exosomes. Luciferase reporter assay further confirmed
that RASA1 was a direct target of miR-132. Exosomes loaded with miR-132, as a vehicle for miRNA
transfer, significantly increased tube formation of endothelial cells. Moreover, subcutaneous injection
of HUVECs pretreated with miR-132 exosomes in nude mice significantly increased their
angiogenesis capacity in vivo. In addition, transplantation of miR-132 exosomes in the ischemic
hearts of mice markedly enhanced the neovascularization in the peri-infarct zone and preserved heart
functions.
Conclusions: The findings suggest that the export of miR-132 via MSC-derived exosomes
represents a novel strategy to enhance angiogenesis in ischemic diseases.

Author(s) Details

Junjie Yang
Department of Biomedical Engineering, School of Medicine and Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Jiacheng Sun
Department of Biomedical Engineering, School of Medicine and Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/243

Circulating Micro RNAs as Novel Disease Biomarkers: Can they be Applied in Daily Clinical Practice? An Update | Chapter 9 | Current Topics in Medicine and Medical Research Vol. 1

MicroRNAs (miRNAs), a large family of short noncoding RNA sequences, modulate gene expression and regulate a wide range of biological processes as cell differentiation, proliferation and development, cell-to-cell communication, cell metabolism and apoptosis. There is evidence that miRNAs may have a role in molecular mechanisms linked to cellular pathways of certain diseases, as viral infections, cancer, diabetes and cardiovascular disease. miRNAs are contained in tissue cells but they are also detectable in extracellular sites, as plasma and other body fluids so they may be identified and quantified in the circulating blood by several techniques. The potential of circulating miRNAs as stable blood-based biomarkers for some diseases is described in this updated review. There are currently no circulating miRNAs that are validated as biomarkers for routinary use in daily clinical practice; lack of significant comparative studies between miRNAs and disease common biomarkers and high detection costs are the main limitations to use these nucleotides in daily clinical practice. In the near future, larger, comparative, long-term and randomized controlled trials must be undertaken to validate these disease biomarkers.  

Author (s) Details

Carella Angelo Michele,
Department of Internal Medicine, "T. Masselli-Mascia" Hospital, 71016 San Severo (Foggia), Italy.

View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/195