MicroRNAs (miRNAs), a large family of short noncoding RNA
sequences, modulate gene expression and regulate a wide range of biological
processes as cell differentiation, proliferation and development, cell-to-cell
communication, cell metabolism and apoptosis. There is evidence that miRNAs may
have a role in molecular mechanisms linked to cellular pathways of certain
diseases, as viral infections, cancer, diabetes and cardiovascular disease.
miRNAs are contained in tissue cells but they are also detectable in
extracellular sites, as plasma and other body fluids so they may be identified
and quantified in the circulating blood by several techniques. The potential of
circulating miRNAs as stable blood-based biomarkers for some diseases is
described in this updated review. There are currently no circulating miRNAs
that are validated as biomarkers for routinary use in daily clinical practice;
lack of significant comparative studies between miRNAs and disease common
biomarkers and high detection costs are the main limitations to use these
nucleotides in daily clinical practice. In the near future, larger,
comparative, long-term and randomized controlled trials must be undertaken to
validate these disease biomarkers.
Author (s) Details
Carella Angelo Michele, Author (s) Details
Department of Internal Medicine, "T. Masselli-Mascia" Hospital, 71016 San Severo (Foggia), Italy.
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/195
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