Concise Teleost Immunology | Book Publisher International

 

This book is based on an overview of fish biology followed by inducer nature, genetic and immune molecules, receptors, cells, tissues and organs of the teleost fish immune system in comparison to that of mammals. In addition to special chapters on the nature of normal, subnormal and abnormal immune responses. Together with immunity to infection and vaccination. The text contains 5  parts, 10 sections and 26 chapters.

 

 

Author (s) Details

Professor Emeritus Dr. Ibrahim Shnawa
Deparment of Medical Biotechnology, College of Medical Biotechnology, AL-Qasim Green University, Babylon, Iraq and College of Nursing Technichians, Hilla University College, Babylon, Iraq.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48006-31-8

 

Genetic Variation of Duchenne Muscular Dystrophy and Cancer | Chapter 3 | Medical Science: Trends and Innovations Vol. 11

Duchenne muscular dystrophy (DMD) is a rare, severe, progressive genetic disorder causing disability and premature death. Mutations in the DMD gene encoding the dystrophin protein lead to the dystrophinopathies of DMD. Despite major therapeutic advances over the last few decades, there are currently no curative therapies for DMD. Gene therapy such as CRISPR-Cas9-based gene editing is a promising experimental approach to treat genetic diseases such as DMD.  Interestingly, it has also been reported that muscular dystrophy patients may be at increased risk of malignancy. Although mutations in the DMD genes have been widely studied, a systematic genetic analysis of all variants, especially single nucleotide polymorphisms (SNPs), of the gene in humans has not been reported. In this study, a systematic analysis of the DMD genetic variants via the Single Nucleotide Polymorphism Database (dbSNP), and annotated the functions of the variants with wANNOVAR was performed. The protein-protein interaction (PPI) network for genetic modifiers identified in DMD patients was explored. DMD genetic alternations in different tumors have also been investigated via cBioPortal. Data mining and visualization were further performed based on the annotation. The study examined a total of 3,627 exonic SNPs in the DMD gene. SNPs are distributed across all exons. The largest category was nonsynonymous accounting for nearly 64% of all mutations. Exon 19 appeared to have the highest density of pathogenic SNP distribution. Nonsense mutation (i.e. stopgain) or frameshift mutation likely leads to more pathogenic. Among the genetic modifiers identified in DMD patients, THBS1 has higher network topological parameters, followed by SPP1, ACTN3 and LTBP4. Network analysis highlighted non-random interconnectivity between the genetic modifiers identified in DMD patients, and potentially shed light on new genetic modifiers by their functional coupling to these known genes. In conclusion, this is the first data mining study with a systematic genetic analysis of all variants, especially SNPs, of the DMD gene in humans. SNPs are distributed across all Exons. The largest category was nonsynonymous accounting for nearly 64% of all mutations. Exon 19 appeared to have the highest density of pathogenic SNP distribution. In addition, our results also suggest DMD gene may serve as a diagnostic and therapeutic target for certain types of cancer.

 

Author (s) Details

 

Hubert Chen
Ivymind Academy, New Jersey, USA.

 

Please see the book here:- https://doi.org/10.9734/bpi/msti/v11/4759

Age-Dependent Prevalence of Loa loa Infection: Microfilaremia and IgG4 as Diagnostic Markers | Chapter 5 | Disease and Health: Research Developments Vol. 5

Background: Loiasis is caused by the human filarial Loa loa which is endemic in the west and Central African forest block. Loiasis infection is marked by long-term stability in infection status. The bases of such stability are not well known. As a preliminary step toward verification of possible genetic involvement in this stability.

Methods: A survey in a homogeneous population (n = 106) of a village from an endemic zone of Gabon was undertaken. Microfilaremia under the microscope was examined, and anti–specific human IgG4 against adult worm Loa loa was measured.

Results: The distribution of Loa loa microfilaremia according to age revealed a significant relationship between age and the presence of microfilariae in the blood (p = 0.0059). The proportion of microfilaremic individuals increased with age until 45 years old and did not exceed 34% as its maximum. The other marker (specific IgG4) increased also significantly with age (p = 0.0038), but in contrast to microfilaremia, the prevalence of specific IgG4, a marker of chronic infection, in the group from 45 years onward reached 100%.

Conclusion: These findings highlight the role of age in defining amicrofilaremic or microfilaremic status in an endemic area and address the issue of the existence of genetic factors controlling the outcome of the parasitological status in L. loa infection.

 

Author (s) Details

Akue, J. P.
Department of Medical Parasitology, Centre International de Recherches Médicales de Franceville (CIRMF), B.P 769, Franceville, Gabon.

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrd/v5/4166

Ethics Involving Research with Biological Tissue Samples in Uganda | Chapter 13 | Novel Research Aspects in Medicine and Medical Science Vol. 6

 Biological fabric sample sharing is necessary for evolving low-revenue countries to develop new information due to a lack of laboratory foundation and human resource ability. There is a general agreement with local researchers concerning the need to obtain approval for research on stocked samples of the Research Ethics Committee. The institution housing the stocked samples and medical dossier is custodian rather than landowner of the biological tissue samples. Tissue giving is associated with many ethico-permissible issues especially between various countries. These moral issues concern individual autonomy, confidentiality, and the believeableness of the researcher. In international cooperations involving genomic and ancestral research the export of biological fabric samples may negatively influence the building of local competency. Regulatory frameworks governing the giving of biological fabric samples need to be in place on account of issues concerning inequitable benefit giving and poor government. This study reviewed the perspectives and belief of the author and local researchers in Uganda concerning biological fabric sample sharing in collaborative hereditary research projects between Uganda and grown high-income countries.

Author(s) Details:

Richard Wismayer,
Department of Surgery, Faculty of Health Sciences, Habib Medical School, IUIU University, Kampala, Uganda and Department of Surgery, Masaka Regional Referral Hospital, Masaka, Uganda.

Please see the link here: https://stm.bookpi.org/NRAMMS-V6/article/view/12150

Unpreventable Causes of Obesity: Genetic Factors and Susceptibility | Chapter 5 | Current Overview on Disease and Health Research Vol. 5

 India is presently going through a rapid-fire health shift, with increase in rise of habitual conditions similar as type 2 diabetes mellitus, hypertension, cardiovascular conditions, sleep diseases, liver conditions, arthritis, depression, cancer and numerous further. rotundity is among one of the leading factors for the development of these conditions. rotundity is on rising trend among all periods and ethnical groups, especially due to physical inactivity and increased energy input in excess of energy expenditure, leading to accumulation of body fat that can be averted. Other adjustable threat factors as socioeconomic status, sleep and numerous others also regard for rotundity and rotundity- related conditions but these factors still, aren't the only determinants of rotundity. Besides adjustable threat factors, there are someun-modifiable threat factors also similar as age, coitus, genetics, race, gravid weight and other molecular factors that may be responsible to some extent. With the global increase in frequence of rotundity and rotundity related conditions, it becomes important to have knowledge about the less given causes of rotundity so as to drop its rising trend so that we can apply applicable and more preventative and interventional strategies.

Author(s) Details:

Naveenta Gupta,
Department of Physiology,Guru Gobind Singh Medical College, Faridkot‑151203, Punjab, India.

Sonia Garg,
Department of Physiology,Guru Gobind Singh Medical College, Faridkot‑151203, Punjab, India.

Khushdeep Singh Arora,
Department of Physiology, Dasmesh Institute of Research and Dental Sciences, Faridkot‑151203, Punjab, India.

Harpreet Kaur,
Department of Obstetrics and Gynaecology, Guru Gobind Singh Medical College, Faridkot‑151203, Punjab, India.

Please see the link here: https://stm.bookpi.org/CODHR-V5/article/view/8438

Unpreventable Causes of Obesity: Genetic Factors and Susceptibility | Chapter 5 | Current Overview on Disease and Health Research Vol. 5

 India is presently going through a rapid-fire health shift, with increase in rise of habitual conditions similar as type 2 diabetes mellitus, hypertension, cardiovascular conditions, sleep diseases, liver conditions, arthritis, depression, cancer and numerous further. rotundity is among one of the leading factors for the development of these conditions. rotundity is on rising trend among all periods and ethnical groups, especially due to physical inactivity and increased energy input in excess of energy expenditure, leading to accumulation of body fat that can be averted. Other adjustable threat factors as socioeconomic status, sleep and numerous others also regard for rotundity and rotundity- related conditions but these factors still, aren't the only determinants of rotundity. Besides adjustable threat factors, there are someun-modifiable threat factors also similar as age, coitus, genetics, race, gravid weight and other molecular factors that may be responsible to some extent. With the global increase in frequence of rotundity and rotundity related conditions, it becomes important to have knowledge about the less given causes of rotundity so as to drop its rising trend so that we can apply applicable and more preventative and interventional strategies.

Author(s) Details:

Naveenta Gupta,
Department of Physiology,Guru Gobind Singh Medical College, Faridkot‑151203, Punjab, India.

Sonia Garg,
Department of Physiology,Guru Gobind Singh Medical College, Faridkot‑151203, Punjab, India.

Khushdeep Singh Arora,
Department of Physiology, Dasmesh Institute of Research and Dental Sciences, Faridkot‑151203, Punjab, India.

Harpreet Kaur,
Department of Obstetrics and Gynaecology, Guru Gobind Singh Medical College, Faridkot‑151203, Punjab, India.

Please see the link here: https://stm.bookpi.org/CODHR-V5/article/view/8438

A Rare Entity of Christ Siemens Touraine Syndrome | Chapter 16 | Highlights on Medicine and Medical Science Vol. 15

 This case study focuses on Christ Siemens Touraine Syndrome, an uncommon condition. Ectodermal dysplasia is an uncommon condition that affects one in every 100,000 babies, with a male predominance. Appendageal abnormalities with facial dysmorphism are the most common symptoms. Hypohidrotic ectodermal dysplasia (Christ-Siemens-Touraine syndrome) and hidrotic ectodermal dysplasia are the two most frequent kinds of ectodermal dysplasia (Clouston syndrome). Clinical recognition differs based on the severity of the symptoms and the problems that accompany them. After infancy, if discovered early and complications are managed properly, the prognosis is good. We present a case of Hypohidrotic Ectodermal Dysplasia in an eight-month-old female. A diverse team approach is frequently required by management. High-temperature protection, early dental examination for proper nutrition, detachable prosthodontics and dental implants, and the use of lacrimal tears to prevent ocular damage are all included.

Author (s) Details

Dr Richa
Department of Pediatrics, TNMC and BYL Nair Hospital, Mumbai, Maharashtra, India.

Dr. Namitha Mohan
Department of Pediatrics, TNMC and BYL Nair Hospital, Mumbai, Maharashtra, India.

Dr. Nishigandha Joshi
Department of Pediatrics, TNMC and BYL Nair Hospital, Mumbai, Maharashtra, India.

Dr. Sushma Save
Department of Pediatrics, TNMC and BYL Nair Hospital, Mumbai, Maharashtra, India.

View Book :- https://stm.bookpi.org/HMMS-V15/article/view/2477

Genetics, Molecular Interactions and Resistance Response of Common Bean (Phaseolus vulgaris L.) Genotypes to Root Knot Nematodes (Meloidogyne spp) | Chapter 6 | Cutting-edge Research in Agricultural Sciences Vol. 3

 The common bean (Phaseolus vulgaris L.) is an essential crop that has become a source of protein for human nutrition. The yield of common beans in the world is limited by many pests, including plant parasitic nematodes. Meloidogyne genus called Root knot nematodes cause serious damage to the common bean among the plant parasitic nematodes. This genus contains more than a hundred organisms that include the world's most toxic bacteria. By taking nutrients and water from plants, they cause harm; plant growth and decreases in yield, root galling and wilting are observed. As nematode resistant and susceptible reactions, common bean varieties and genotypes can demonstrate responses. The genetics, molecular interactions and resistance response of common bean beans in this chapter Genotypes were administered against root knot nematodes. There was discussion of common bean and root knot nematode interactions, molecular plant nematode interactions, determination of the genotype tolerance of common bean to root knot nematodes, the effect of root knot nematodes on common bean genotypes, and the effect of genotypes on nematode reproduction. Overall , this chapter is critical for the understanding of root knot nematode resistance responses for common bean varieties and genotypes, and for future studies of plant nematode interactions in breeding.

Author (s) Details

Dr. Refik Bozbuga,
Biological Control Research Institute, Nematology Lab, 01321, Yuregir, Adana, Turkey

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/274