Role of Fusobacterium nucleatum and KRAS Genotype in Colorectal Cancer Development | Chapter 9 | An Overview of Disease and Health Research Vol. 9

 

Fusobacterium nucleatum (Fn) and activating mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) are increasingly recognised as synergistic drivers of colorectal cancer (CRC). Fn promotes tumorigenesis through several mechanisms, such as virulence factors including FadA and Fap2. KRAS mutations amplify proliferative and inflammatory signalling. This chapter explores how Fn enhances KRAS-driven oncogenic cascades and how KRAS-mutant epithelium fosters bacterial colonisation. We also examine KRAS as a prognostic biomarker and highlight emerging microbiome-targeted strategies. Understanding this microbial–genetic crosstalk provides a foundation for precision prevention and combined therapeutic approaches in CRC.

 

Author(s) Details

Ahmed Dewan
College of Life Sciences, Anhui Agriculture University, Hefei 230036, China.

 

Ivan Tattoli
Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.

 

Maria Teresa Mascellino
Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.

 

Please see the book here :- https://doi.org/10.9734/bpi/aodhr/v9/7037

The Significance of Oral Fusobacterium nucleatum in Female Breast Cancer: A Brief Overview | Chapter 2 | Research Developments in Medicine and Medical Science Vol. 4

 This orderly review and meta-analysis implies a important relationship between spoken FN species and their role in female-distinguishing BC pathogenesis, highlighting their biography- marker potentiality. The most low cancer in the world, feelings cancer has an increasing occurrence and is more likely to affect postpubertal women from all racial and ethnic upbringing. Recent findings of spoken Fusobacterium nucleatum species in cancerous human conscience tissue have highlighted the significance of microbes in the pathogenesis of cancer.  This orderly review was created in accordance with the chosen reporting system for orderly reviews and meta-analyses (PRISMA). AXIS form analysis revealed 78.70% of items with a positive equivalence between oral Fusobacterium nucleatum and female-particular breast cancer. The risk of feelings cancer development raised with significant levels of spoken Fusobacterium nucleatum due to gingivitis/ periodontitis (relative risk = 1.78, 95% assurance interval = 1.63–1.91). Low-moderate statistical variety was found (I2 = 41.39%; P = 0.02), and the importance of periodontal rank on breast cancer pathogenesis was persistent (relative risk = 1.24, 95% confidence interval = 1.01–1.30). Oral Fusobacterium nucleatum class are a risk factor for breast tumor development, accordingly elevating their biomarker potentiality. Our judgments increase understanding of the complexities of this friendship with regard to adult female populations and grant permission be able to lower/prevent the risk of BC growth globally, fundamentally changing the course of both healing and dental prognostics.

Author(s) Details:

Fariah I. Gaba,
Mondzorg Scheveningen Private Dental Clinic, Renbaanstraat 75, 2586 EZ, The Hague, The Netherlands.

Raquel Carcelen Gonzalez,
Department of Medicine and Surgery, Faculty of Health Sciences, University Cardenal Herrera UCH-CEU. Valencia, Spain.

Raquel Gonzalez Martinez,
Department of Dentistry, Faculty of Health Sciences. University Cardenal Herrera UCH-CEU, Valencia, Spain.

Please see the link here: https://stm.bookpi.org/RDMMS-V4/article/view/9831