Preventing Cancer or Finding a Cure: Which is the Better Approach? | Chapter 3 | Medical Science: Trends and Innovations Vol. 2

The rate of dying from cancer in the US has declined steadily over the past two decades. During the last ten years for which data are available, the rate of new cancer diagnoses decreased by about 2% per year in men and remained about the same in women. Huge resources are being expended in search of cancer therapies, with limited success. Cancer is believed to originate from an irreversible genetic alteration, a part of both normal and abnormal biological processes. It is questionable whether such essential biological behavior can be put under sufficient control to cure cancer. Given that events leading to cancer development appear to be too complex to be successfully manipulated by drug therapies, initiatives to “cure cancer” should be reevaluated and reconsidered, with a likely anticipated conclusion that taking steps to limit cancer initiation might be more cost-effective, and hence focus research efforts on measures to prevent rather than cure cancer. Appropriate steps should be taken vigorously and effectively to remove from our environment (for example, the air, water, and food supply) pollutants identified as initiators and promoters of biological pathways that lead to cancer.

 

Author (s) Details

 

Petrak K
Matrx Pharmaceuticals, Inc., USA.

 

Please see the book here:- https://doi.org/10.9734/bpi/msti/v2/4004

A Healthy Balance of Homeostasis by Epigenetic Regulator SIRT1 May Prevent the Development of a Specific "Soil" that Supports Metabolic Disorders and Related Cancers| Chapter 5 | Current Overview on Disease and Health Research Vol. 4

 SIRT1 was found in 1979, however expanded interest in this protein didn't come until 20 years after the fact, when its overexpression was accounted for to broaden the life expectancy of yeast. From that point forward, a few examinations have shown the advantages of its expanded articulation in forestalling or deferring of numerous sicknesses.

As a histone deacetylase, SIRT1 is an epigenetic controller however has a few non-histone targets engaged with digestion, energy detecting pathways, circadian hardware, and fiery guideline. Unsettling influences in these interconnected cycles cause various illnesses, but they appear to have a typical root in the lopsidedness of provocative cycles and lower levels or inactivation of SIRT1.

SIRT1 inactivation has likewise been embroiled in the seriousness of COVID-19, and its low level has been viewed as an indicator of uncontrolled COVID-19. A few different sicknesses, like metabolic illness, heftiness, diabetes, Alzheimer's infection, cardiovascular sickness or discouragement, are related with constant irritation and comparatively show diminished SIRT1 level.

It has as of late become realized that SIRT1 can be inducible by calorie limitation/legitimate sustenance, actual work and proper profound state. To be sure, a better metabolic state is related with more significant levels of SIRT1 articulation. These recommend that a reasonable way of life as a non-pharmacological therapy might be a helpful device in the counteraction of irritation or metabolic aggravation related illnesses, and in clinical practice it tends to be essential for the correlative treatment to accomplish better remedial reaction and personal satisfaction.

In this audit we expected to connect the useful impacts of SIRT1 to illnesses where its levels are decreased. Also, we looked to gather proof for mediations or therapies that increment SIRT1 articulation, accordingly open the chance of involving them as preventive or correlative treatment in clinical practice.

Author(s) Details:

Zsuzsanna Nemeth,
Department of Internal Medicine and Oncology, Semmelweis University, Budapest -1083, Hungary.

Eva Kiss,
Department of Internal Medicine and Oncology, Oncology Profile, Semmelweis University, Budapest - 1083, Hungary.

Istvan Takacs,
Department of Internal Medicine and Oncology, Semmelweis University, Budapest -1083, Hungary.

Please see the link here: https://stm.bookpi.org/CODHR-V4/article/view/8003

Cancer Prevention and Control in Bangladesh: Mass Awareness is Needed | Chapter 1 | New Insights into Disease and Pathogen Research Vol. 5

Here we discuss the mass population perception and life style practices on cancer in a group of Bangladeshi people. Based on our conducted survey findings, we highlighted the important issues to address for reducing the cancer incidence of the country. In 2016, we reported a cancer knowledge and perception survey findings conducted on Bangladeshi people. The survey questionnaire was developed based on the WHO country level cancer risk assessment report. A total of 407 respondents were invited randomly using social networks and personal communication to take part into the survey. We included 253 respondents with information of knowledge and current life style practices towards cancer prevention. We found that only one-third of the respondents irrespective of age groups- No vs. Yes: 96 (37.95%) vs. 157 (62.05%), p<0.00001 had known that cancer can be prevented by modifying life styles. Female respondents had remarkably lower level of knowledge and perception on specific cancer prevention knowledge compared to their male counterpart. Irrespective of age groups and gender, about 67% (n=169) and 45% (n=113) of the respondents knew about the impact of chewing or smoking tobacco and non-food grade preservatives, chemicals, ripening agents on developing cancer, respectively; however, only one-fourth (n=73, 28.65%) respondents knew that physical inability or obesity is a risk factor for cancer. Stopped/never smoking, avoid consuming food with food additives/preservatives, alcohol consumption were found the three most common practices among the respondents towards cancer prevention. The study provides important baseline information on preventable cancer risk perception in Bangladesh. In this chapter, we comprehend our survey findings in details including the cancer screening perception and practices of the respondents. Our results indicate that a comprehensive cancer awareness program is needed to reduce the cancer burden in Bangladesh. 

Author(s) Details

Dr. Kanchan Chakma,
Department of Biochemistry and Molecular Biology, University of Chittagong, Bangladesh and Health Awareness Network for Disease Prevention (HAND), USA.

Dr. Chandra Nath Roy,
Health Awareness Network for Disease Prevention (HAND), USA and Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Dr. Anjan Kuman Das,
Delta Medical College and Hospital, Dhaka, Bangladesh.

Dr. Mohammad Aminul Hoque,
Department of Gastroenterology, Colonel Malek Medical College, Manikgonj ,  Bangladesh

Dr. Asish Kumar Sarkar
 Department of Radiology and Imaging, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/196