Serum Selenium Levels in Prostate Cancer and Benign Prostatic Hyperplasia: A Comparative Study in Nigerian Patients | Chapter 12 | Medical Science: Recent Advances and Applications Vol. 11

 

Prostate cancer (PCa) is the most common cancer among men and also a significant cause of mortality. Over one million new cases were diagnosed in 2020, and over 300,000 deaths from prostate cancer were recorded in the same year. Selenium, a trace metal, has been investigated for its potential role in prostate cancer through mechanisms such as angiogenesis inhibition, modulation of cell death, and androgen receptor signalling. This study compares the serum Selenium (Se) levels of patients diagnosed with prostate cancer versus those diagnosed with Benign Prostate Hyperplasia (BPH).

 

The study was carried out in the University of Port Harcourt teaching Hospital (UPTH) and Gbeye hospital. A total of 81 patients who gave their consent, and had lower urinary tract symptoms were recruited over a 6 months period. 40 patients had Benign prostate enlargement, while 41 patients had prostate cancer. Blood samples were collected and analysed for Se using an Atomic absorption spectrophotometer. Patient biodata, prostate-specific antigen, and serum selenium levels were collected and analysed using SPSS version 20.

 

The mean age of respondents in this study was 60(9) and 62(9) for BPH and PCa respectively. The mean BMI was 25.81 (2.04). The mean PSA of the BPH and PCa groups were 2(1) and 18(5) respectively P <0.001. The serum selenium level for those with BPH was 0.17 (0.07), while that for those with PCa was 0.14 (0.07) with a p-value of 0.073.

 

This study found that serum Se was lower in patients with PCa compared with controls (BPH) but this difference was not statistically significant. The role of Se in prostate diseases and, indeed, prostate cancer still requires further research. This is particularly important in West Africa, where the burden of prostate cancer is high.

 

 

Author(s) Details

Okigbeye Danagogo
Department of Surgery, Rivers State University Teaching Hospital, Port Harcourt, Rivers State, Nigeria.

 

Egbuchilem Chisor-Wabali
Department of Surgery, Rivers State University Teaching Hospital, Port Harcourt, Rivers State, Nigeria.

 

Please see the book here :- https://doi.org/10.9734/bpi/msraa/v11/6317

Research on the Lower Urinary Tract Infections among Patients Diagnosed of Benign Prostate Hyperplasia in Federal Medical Centre, Bida, North Central, Nigeria | Chapter 16 | Research Trends and Challenges in Medical Science Vol. 5

 

This current study was aimed to identify the aetiology of bacteria associated with Benign Prostate
Hyperplasia (BPH) and to determine the antimicrobial susceptibility pattern of the isolated organisms
in the community. Urine samples were collected from a total of 536 patients with indwelling urinary
catheter on hospital admissions that were clinically diagnosed of BPH. Subjects were between the
ages of 41 and 100 years. Data was coded, computed and analyzed using SPSS version 16.0 and p
values ≤0.05 was considered to be statistically significant. Our research showed that the incidence of
urinary tract infections in this study population was (62.5%), and statistically not significant (p- value =
0.296, mean age=5.13, mode=4.00 and S.D ±2.03). Escherichia coli 247(67.7%) was the most
prevalent uropathogen followed by Staphylococcus aureus 34(9.3%), Pseudomonas species
29(7.9%), Klebsiella species 10(2.7%), Proteus species 10(2.7%), Candida albicans 4(1.1%) and
Staphylococcus albus 1(0.3%) being the least isolates. The highest uropathogen was susceptible to
Nitrofurantoin (61.9%) followed by Levofloxacin (44.1%) and least susceptible to Gentamycin (12.1%),
Nalidixic acid (12.1%), Augmentin (7.7%) and Ampicillin (0.4%). Our research showed high incidence
rate of 62.5% of UTIs among patients with indwelling urinary catheter and diagnosed of benign
prostate hyperplasia in our community. This is of serious concern to all stake holders in health
industry. We observed that the most susceptible antimicrobial agent in this locality is Nitrofurantoin
(61.9%) and Levofloxacin (44.1%).

Author (s) Details

O. A. Akobi
Department of Medical Microbiology, Federal Medical Centre, Bida, Niger-State, Nigeria.

E. C. Akobi
Department of Nursing, Federal Medical Centre, Bida, Niger State, Nigeria.

E. G. Emumwen
Department of Medical Microbiology, Federal Medical Centre, Bida, Niger-State, Nigeria.

E. O. Uzoigwe
Department of Medical Microbiology, Federal Medical Centre, Bida, Niger-State, Nigeria.

E. F. Emumwen
Health Centre Clinic, Federal Polytechnic Bida, Niger-State, Nigeria.

P. O. Uyigue
Department of Medical Laboratory Science, Achiever University Owo, Ondo-State, Nigeria.

S. A. Akinola
Oyo-State Hospital Management Board, Ibadan, Nigeria.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/264

Author (s) Details

O. A. Akobi
Department of Medical Microbiology, Federal Medical Centre, Bida, Niger-State, Nigeria.

E. C. Akobi
Department of Nursing, Federal Medical Centre, Bida, Niger State, Nigeria.

E. G. Emumwen
Department of Medical Microbiology, Federal Medical Centre, Bida, Niger-State, Nigeria.

E. O. Uzoigwe
Department of Medical Microbiology, Federal Medical Centre, Bida, Niger-State, Nigeria.

E. F. Emumwen
Health Centre Clinic, Federal Polytechnic Bida, Niger-State, Nigeria.

P. O. Uyigue
Department of Medical Laboratory Science, Achiever University Owo, Ondo-State, Nigeria.

S. A. Akinola
Oyo-State Hospital Management Board, Ibadan, Nigeria.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/264