Despite many years of ET research, its pathophysiology
remains unknown. Essential tremor (ET) is common and frequently affects quality
of life. The case outlines a safe and novel approach to ET treatment that can
either be trialed in treatment-refractory cases or used in tandem with
traditional therapy. Although traditional pharmacotherapy is sometimes
effective, patient factors, lack of efficacy, and poor adherence sometimes
limit its efficacy. Furthermore, the pathophysiology of ET is not fully
understood, but it is increasingly regarded as a highly heterogeneous disorder
of cerebellar pathways underpinned by low gamma-aminobutyric acid (GABA) tone.
This knowledge and review of recent data prompted the development of a
multi-modal nutritional therapy approach to target three putative ET pathways:
(i) diet (specifically adopting a Mediterranean diet); (ii) GABA tone (through
oral supplementation); and (iii) L-tryptophan/vitamin B pathways (Triptobel
oral supplement). The approach is illustrated here with the case of a
13-year-old boy with ET causing severe functional impairment. A full history
revealed no exposure to toxins and there was no family history of ET or other
movement disorders. He was prescribed a sugar-free, Mediterranean-style diet
rich in whole grains as a carbohydrate source and rich in vegetables, fruit,
olive oil, and fish. After two months of therapy, his tremor decreased
significantly and he regained normal function. In conclusion, ET is a common
disorder that affects quality of life and is often treatment-refractory. The
case identifies and highlights several areas worthy of further investigation,
particularly with respect to establishing the role of oral GABA and vitamin
B/tryptophan supplementation in ET. Given the safety and positive health
benefits of this novel nutritional therapy approach, it can be trialed in
patients with ET either with or without concurrent traditional pharmacotherapy.
Author(s)details:-
Maja Roje Novak
Private Neurological Practise, Pavla Hatza 27, 1 Zagreb, Croatia.
Please See the book
here :- https://doi.org/10.9734/bpi/acmms/v5/2684
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