The
aim of this work was the characterisation of tea tree oil calcium-alginate
microparticles prepared using prilling vibration technology and drying
according to three different methods (oven at 40°C, dynamic drying under
air-flow at 22°C and freeze-drying). Microparticles were characterized by
stereomicroscopy, scanning electron microscopy, thermogravimetric analysis and
as regarding essential oil content and in vitro release. After oven drying and
air-flow drying processes, microparticles were partially aggregated. They had a
high oil content (more than 50% w/w) and were able to release tea tree oil in
about 3 hours. Freeze-drying gave microparticles well separated to each other,
characterized by the highest dimensions (about 500 µm), a good essential oil
content and the fastest release rate. For all systems, the oil content
decreased during storage with a total loss, after 5 months, ranging from 10%
(air-flow dried microparticles) to 24% (oven-dried microparticles).
Author(s) Details
Lorena Segale
Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy and APTSol Srls, Largo Guido Donegani 2/3, 28100 Novara, Italy.
Andrea Foglio Bonda
Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy and APTSol Srls, Largo Guido Donegani 2/3, 28100 Novara, Italy.
Lorella Giovannelli
Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy and APTSol Srls, Largo Guido Donegani 2/3, 28100 Novara, Italy.
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/192
Author(s) Details
Lorena Segale
Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy and APTSol Srls, Largo Guido Donegani 2/3, 28100 Novara, Italy.
Andrea Foglio Bonda
Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy and APTSol Srls, Largo Guido Donegani 2/3, 28100 Novara, Italy.
Lorella Giovannelli
Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy and APTSol Srls, Largo Guido Donegani 2/3, 28100 Novara, Italy.
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/192
No comments:
Post a Comment