Chronic kidney disease is one of the great challenges in
daily life of veterinary doctors, and the lack of knowledge on this subject
leads us to question on how we can generate early diagnoses and thus, more effective
therapeutic treatments. To what extent can treating kidney disease be effective
if the mechanisms with which the kidney works are unknown?. We know that under
normal conditions the kidney nephrons of dogs and cats are prepared to maintain
homeostasis in the body, this mechanism is most often sustained until advanced
stages of disease. In chronic kidney disease, regardless of the type of initial
injury, the frames of the different diseases are usually degenerative, chronic
and progressive, and the damage caused to the kidneys is irreversible, thus
deteriorating the glomeruli, tubules and interstitium, culminating with nephron
death and progressive decrease in glomerular filtration rate; This condition
causes the animal to manifest clinical symptoms when there is a change from the
phase of the disease to insufficiency. In the disease, morphophysiological
adaptations are established that allow the kidneys to maintain balance in the
body; when these adaptations attend a critical point in company with the exacerbation
of the compensatory mechanisms, the onset of functional deficit is generated,
initially characterized by the incapacity of the renal tubule to concentrate
urine, generating polyuria with compensatory polydipsia, finally rendering the
kidneys insufficient to maintain homeostasis, frame known as kidney failure, a
condition in which more than 75% of the kidneys are not functional; clinically
at this stage there is not to much to do. This book was produced with the
purpose of make easier to the small animal clinician, understand the
functioning, diagnosis and treatment of the renal system.
Author(s)
Details Dr. Pedro Pablo Martinez Padua
Betel Center of Veterinary Specialties, Bogotá, Colombia.
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/209
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