\(Gd^{3+}\) / \(Sm^{3+}\) Co-doped Lead Alumino-borophosphate Glasses: Synthesis and Characterization | Chapter 5 | Chemical and Materials Sciences: Research Findings Vol. 4

 

A series of multicomponent (Lead, Sodium, Aluminum and Zinc) Borophosphate glasses doped with Sm3+ and Gd3+ ions with molar composition xPbO - (40-0.5x)B2O3 - (40-0.5x)P2O5 - 9.0Na2O - 1.0Al2O3 - 9.6ZnO - 0.2Sm2O3 - 0.2Gd2O3 (x = 10, 15, 20, 25, 30, 35) was synthesized using the conventional melt quenching technique. The amorphous nature of these glasses was confirmed with XRD studies. The density measurement was done by using Archimedes' principle with the help of a KEROY mechanical balance. The density measurements show a regular and systematic increase in density from 3.6008 g/cm3 to 4.6397 g/cm3 with an increase in PbO content in exchange for the two glass formers. The optical absorption spectra of these glasses were recorded by using a UV/visible spectrometer (Shimadzu, Japan) in the wavelength range of 200–1100 nm at normal incidence. The values of Eg for the glass samples of the series decrease with an increase in PbO content. The synthesised samples may find applications for energy converters, X-ray dosimeters, and radiation shielders/sensors.

 

Author (s) Details

Randev Singh
Department of Physics, Sri Guru Teg Bahadur Khalsa College, Sri Anandpur Sahib, Punjab, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/cmsrf/v4/5726

Study on Isolation, Characterization, and Docking Studies of Isolated Compounds as Antidiabetic Molecules from Cressa cretica | Chapter 16 | Technological Innovation in Pharmaceutical Research Vol. 9

 The goal of this work was to use spectroscopic analysis and molecular docking investigations to examine the diabetic effect of phytocompounds derived from Cressa cretica Linn. Methods: 2-Isopropyl-4-(1-methyl-dodeca-2,4-dienyloxy)-benzene-1,3,5-triol (Compound CN-01) and 11-Methyl-dodeca-2,4,6,8,10-pentenoic acid 2,3-dihydroxy-5-methyl-phenyl ester (Compound CN-02) were obtained in pure form from a coarse powder of the complete plant of C. cretica. The target protein's three-dimensional structure was retrieved from the Protein Data Bank (www.rcsb.org), and the ligand files CN-01 and CN-02 were converted to MDL Molfile (V2000) format using Chem Sketch 2017.2.1. Because these files couldn't be directly used in AutoDock 4.0 tools, they had to be converted to PDB files using an open babel tool. Spectroscopic investigation yielded compounds, which were then screened using AutoDock 4.0 techniques. An existing phytochemical from the plant C. cretica, CN-01 and CN-02, had the greatest fitness docking score and hence potentially be an effective antidiabetic medication, according to a docking research. Conclusion: Based on molecular docking research, we found that the receptor (glycogen phosphorylase protein) holds a promising lead target formation against diabetes (minimum hydrogen bond length and maximum docked score). As a result, these molecules can be employed effectively as medications to treat diabetes, as indicated by docking scores.

Author(s) Details

Dr. Sangeeta Rani
Department of Pharmacognosy, S.D. College of Pharmacy and Vocational Studies, Muzaffarnagar, Uttar Pradesh, India.

Dr. Kavita Gahlot
Department of Pharmacognosy, IFTM University, Moradabad, Uttar Pradesh, India.

Dr. Arvind Kumar
Department of Pharmaceutical Chemistry and Drug Design, S.D. College of Pharmacy and Vocational Studies, Muzaffarnagar, Uttar Pradesh, India.

View Book :-  https://stm.bookpi.org/TIPR-V9/article/view/2529