Targeting Chronic Oxidative Stress: Ozone Therapy as a Key Modulator in Restoring Redox Homeostasis | Chapter 5 | An Overview of Disease and Health Research Vol. 9

 

Chronic degenerative diseases—including cardiovascular disorders, type II diabetes, chronic obstructive pulmonary disease, and neurodegenerative conditions—constitute the leading causes of disability and mortality worldwide. These disorders share common pathogenic mechanisms, notably chronic inflammation and sustained oxidative stress, which are only partially addressed by conventional pharmacological therapies. Restoration of redox homeostasis, therefore, represents a critical unmet therapeutic objective.

 

This review examines integrative strategies aimed at modulating oxidative stress, including lifestyle interventions such as caloric restriction and regular physical exercise, as well as selected bioactive dietary compounds. While these approaches contribute to improved metabolic regulation and may enhance endogenous antioxidant defences, their efficacy is often limited by poor adherence, variable bioavailability, and modest or inconsistent clinical impact.

 

In contrast, particular emphasis is placed on controlled ozone therapy administered as major ozonated autohemotherapy, which uniquely exploits a hormetic mechanism to activate endogenous adaptive responses. When applied within a precisely defined therapeutic window, ozone does not act as a direct pharmacological agent but as a transient oxidative stimulus, generating secondary messenger molecules such as hydrogen peroxide and lipid-derived electrophiles. These signals activate key cytoprotective pathways, most notably the Nrf2-dependent phase II antioxidant and detoxification system, leading to enhanced redox balance, modulation of chronic inflammation, and improved tissue oxygen utilisation.

 

Unlike exogenous antioxidant supplementation, which primarily affects the extracellular compartment, ozone therapy induces an intracellular adaptive response by stimulating the body’s own defence systems. This mechanistic distinction may explain its broader and more sustained effects in chronic diseases characterised by progressive oxidative stress. Clinical observations suggest that, when integrated with standard medical treatments and applied before irreversible tissue damage occurs, ozone therapy may offer meaningful functional and symptomatic benefits.

 

Importantly, the translational relevance of redox-modulation therapies depends on the adoption of standardised clinical procedures, precise dosing protocols, and appropriate regulatory oversight to ensure safety, reproducibility and clinical validity. While emerging clinical evidence suggests that controlled ozone therapy may integrate conventional treatments in selected chronic degenerative conditions, further well-designed clinical trials and harmonised guidelines are required before broader clinical implementation.

 

 

Author(s) Details

Emma Borrelli
Neurosurgical Unit, Public Outpatient Clinic of Ozone Therapy, University Hospital Le Scotte, Siena, Italy.

 

Please see the book here :- https://doi.org/10.9734/bpi/aodhr/v9/7024

Combined Local and Systemic Ozone Therapy in the Treatment of the Low Back Pain: A Proposed Protocol and a Suggested Mechanism of Action | Chapter 1 | Recent Developments in Medicine and Medical Research Vol. 3

 UV-visible (UV-vis), steady-state, and time-resolved photoluminescence spectroscopies are used to investigate the photophysical properties of freshly synthesised oligophenylene derivatives in this chapter. Knoevenagel condensation of produced oligo[4-(methoxyphenyl) acetonitrile] (OMPA) with various chemical groups yields the examined oligophenylene derivatives. Significant changes in photo-physical properties were observed as a result of the chemical alterations. The insertion of a dimethyl-amine group on the backbone of the OMPA oligomer reduces the optical band gap and red-shifts the absorption and photoluminescence capabilities. This is a symptom of an intermolecular charge transfer that took place as a result of the chemical alteration. Meanwhile, the addition of aromatic chemical groups (anthracene and thiophene) to the produced oligophenylene improves its luminous properties. The thermal characteristics change as a result of the chemical insertion of the focussed chemical groups.

Author (S) Details

Emma Borrelli

Department of Medical Biotechnologies, University of Siena, Italy.

View Book :- https://stm.bookpi.org/RDMMR-V3/article/view/4148

The Problem of Chronic Oxidative Stress and the Systemic Indirect Ozone Therapy as a Possible Solution | Chapter 16 | Highlights on Medicine and Medical Research Vol. 4

 A significant number of studies have found that unhealthy habits, such as a high-fat, high-salt diet, poor physical activity, and cigarette smoke, are a direct or indirect cause of cardiovascular disease, chronic respiratory disease, diabetes, and neurodegenerative diseases. A major increase in circulating reactive oxygen species (ROS), proinflammatory cytokines, and acute-phase proteins is the primary cause of death in all of these diseases. As a result, in addition to promoting healthy diets and minimising alcohol and tobacco use, it appears that correcting chronic oxidative stress during the development of chronic pathology is important. As a consequence, anti-hypertensive, anti-cholesterolemic, and anti-diabetic medications must be paired with a modulator capable of re-establishing the oxidant/antioxidant balance in cells. The medical community tends to disregard the promising biochemical and clinical effects of judicious application of ozone in the atrophic form of ARMD, chronic vasculopathies, Type II diabetes, chronic obstructive pulmonary disease (COPD), wound healing disorders, orthopaedics, and dentistry. The fact that ozone therapy can be used to treat a variety of diseases has been ridiculed by sceptical scientists who are unaware that when ozone is dissolved in plasma water, it reacts immediately with antioxidants and polyunsaturated fatty acids, generating two messengers capable of activating blood, endothelial, and a variety of parenchyma cells, all of which have different functions and are responsible for different diseases. The use of systemic indirect ozone therapy to treat chronic oxidative stress and associated pathologies is a safe and successful process.

Author (s) Details

Dr. Emma Borrelli
Postgraduate Course of Oxygen Ozone Therapy, Department of Medical Biotechnologies, University of Siena, Italy.

View Book :- https://stm.bookpi.org/HMMR-V4/article/view/565