A Brief Study on Pyruvate in Novel Intervention of Diabetes | Chapter 06 | Issues and Developments in Medicine and Medical Research Vol. 9

 The purpose of this paper is to provide a quick overview of pyruvate's impact on diabetes. Pyruvate may be a potential therapeutic for diabetes and related organ problems, according to recent breakthroughs in pyruvate research. Pyruvate protection against diabetes may work by maintaining glycolysis and reactivating pyruvate dehydrogenase activity in the tricarboxylic acid cycle, correcting the Warburg effect in diabetic glucometabolic diseases. Pyruvate's anti-hypoxia, anti-oxidative stress, anti-acidosis, anti-apoptosis, anti-advanced glycation end products (AGEs), and insulin secretion stimulation properties may convert the diabetic vicious loop virtuous in the commencement and progression of the diabetic process. This review offered a new viewpoint on pyruvate's superior biological and pharmacological features in the treatment of diabetes, as well as experimental and clinical evidence for pyruvate intervention in diabetes. Based on WHO-ORS, the novel pyruvate modified oral rehydration salt (Pyr-ORS) may be useful in the prevention and treatment of diabetes in a broad population. More research and clinical trials are desperately needed.

Author(S) Details

Zhou, Fang-Qiang
Fresenius Medical Care, Dialysis Centers in Chicago, Illinois, USA.

View Book:- https://stm.bookpi.org/IDMMR-V9/article/view/5841

Novel Pyruvate-Enriched Medical Solutions and Beverages | Chapter 06 | Issues and Developments in Medicine and Medical Research Vol. 5

 This review's goal is to introduce new applications for pyruvate-enriched fluids. Since a half-century ago, pyruvate has been extensively and carefully investigated. Pyruvate is a unique anion that is more advantageous in protecting numerous cell/organ metabolism and function than anions found in commercial medical fluids and health beverages, according to a large body of experimental studies in both animals and people, both in vitro and in vivo. The robust benefits of pyruvate action include improved anoxia/hypoxia tolerance, correction of hypoxic lactic acidosis, and improvement of glucometabolic disorders, as well as anti-oxidative stress/inflammation and mitochondrial protection, leading to reversal of the Warburg effect in a variety of pathogenic attacks, such as severe hypoxia/ischemia, hypo/hyperglycemia, trauma/burn, and sepsis. In vivo studies in animals and humans have revealed pyruvate protections with no clinical side effects. Due to therapeutic effects as well as volume expansion, innovative pyruvate-enriched fluids, including crystalloids and colloids, would be preferable to current fluids in clinical resuscitation. In oral rehydration, peri-operative fluid management, and prehospital rescue, pyruvate-enriched oral rehydration salt (Pyr-ORS, equimolar pyruvate replacement of alkalizers in WHO-ORS) would be more advantageous than WHO-ORS. Oral Pyr-ORS-based beverages, on the other hand, may be beneficial in plateau tourism, diabetic management, and anti-aging. The most important animal trials and human testing with appropriate pyruvate dosages were noted in this study, demonstrating clinical usefulness and safety and unveiling novel Pyr-ORS-based beverages as both medical care fluids and functional drinks in endurance workouts. Pyruvate's implementation in clinical circumstances as a novel nutritional component would be another major medical breakthrough in this century.

Author(S) Details

Zhou, Fang-Qiang
Fresenius Medical Care, Dialysis Centers in Chicago, IL, USA.

View Book:- https://stm.bookpi.org/IDMMR-V5/article/view/5581