Intra-Arterial Therapy with 90Y for Hepatic Tumour Lesions: A Review | Chapter 5 | Medical Science: Recent Advances and Applications Vol. 12

 

Aim: The objective of this integrative review study was to identify existing studies in the literature that provide information on the advances associated with the therapeutic technique of radioembolization with 90Y-labelled microspheres and its relationship within radiology, from the perspective of expanding the culture of radiological protection.

 

Methodology: Through an integrative literature review, the advances associated with the therapeutic technique of radioembolization with yttrium-90 (90Y) microspheres were analysed, highlighting the reduction of radiation dose in medical and occupational exposures, as well as evaluating the role of intra-arterial radionuclides in terms of survival benefit, progression-free survival, and quality of life.

 

Results: The results showed that therapeutic association with radioembolization using 90Y microspheres was effective in the treatment of liver tumours, but further studies are still required to determine ideal administration protocols and combination with radionuclide therapy.

 

Conclusion: Moreover, additional research is needed to establish the absorbed dose delivered to the tumour, taking into account its specific radiosensitivity and the desired final mass of the treated lesion.

 

 

Author(s) Details

Adrine Silveira da Silva
Universidade Franciscana - UFN, 97010-032, Santa Maria, RS, Brazil.

 

Luísa Vargas Cassol
Universidade Franciscana - UFN, 97010-032, Santa Maria, RS, Brazil.

 

Cássio Mori da Silva
Universidade Franciscana - UFN, 97010-032, Santa Maria, RS, Brazil.

 

Jéssica Fetzer da Costa Rosa
Universidade Franciscana - UFN, 97010-032, Santa Maria, RS, Brazil.

 

Vagner Bolzan
Instituto Federal de Santa Catarina - IFSC, 88075010, Florianópolis, SC, Brazil.

 

Silvio Atilio Michelin Bertagnolli
Universidade Federal de Santa Maria - UFSM / Hospital Universitário de Santa Maria - HUSM, 97105-900, Santa Maria, RS, Brazil.

 

Thiago Victorino Claus
Universidade Franciscana - UFN/Hospital Universitário de Santa Maria - HUSM, 97105-900, Santa Maria, RS, Brazil.

 

Please see the book here :- https://doi.org/10.9734/bpi/msraa/v12/6367

Radiation Dose Dynamics: Analyzing Activity-Linked Levels in the Nuclear Medicine Unit at Mulago National Referral and Teaching Hospital | Chapter 11 | Current Research Progress in Physical Science Vol. 1

 

The present study reports a survey of the radiation dose levels, radiation dose levels versus the activity used in the different working areas of the Nuclear Medicine Unit of Mulago Hospital while using 99mTc as the main radionuclide. The radiation dose levels in nuclear medicine workplaces have garnered significant attention from researchers. An extensive survey was conducted to compare radiation doses with the activities performed in the working areas of the nuclear medicine unit at Mulago National Referral and Teaching Hospital. This survey utilized two LiF TLD-100 dosimeter badges, calibrated alongside a standard 90-Strontium radiation source. The mean monthly effective radiation dose levels varied from 0.09 ± 0.05 mSv/month in the staff room to 1.23 ± 0.05 mSv/month in the waste collection room. Similarly, annual effective radiation dose levels ranged from 1.03 mSv/year to 14.77 mSv/year in the staff room and waste collection room, respectively. Statistical analysis using MatLab revealed a power distribution pattern between monthly radiation dose levels and activity. The hot laboratory and the waste collection/storage rooms had the highest radiation dose levels. The waste collection room radiation dose levels are higher than those of the hot laboratory because the room contained wastes from day one of the working week of the Unit up to the last day when the wastes were being taken away for discharge. The measured radiation dose levels were found to be within the safety limits recommended by international agencies such as the International Commission on Radiological Protection (ICRP) and the International Atomic Energy Agency (IAEA). The monthly radiation dose levels in the working areas depended on the monthly activity used and are far well below the established IAEA and ICRP standards.

 

Author(s)details:-

 

Dr. Peter Opio
Department of Physical Sciences, Faculty of Science, Technology and Innovation, Mountains of the Moon University, P.O. Box-837, Fortportal, Uganda.

 

Dr. Akisophel Kisolo
Department of Physics, College of Natural Science, Makerere University, P.O. Box-7062, Kampala, Uganda.

 

Dr. Zeridah Muyinda
Department of Radiology and Radiotherapy, College of Health Sciences, Mulago National Referral and Teaching, P.O. Box-7272, Kampala, Uganda.

 

Please See the book here :-  https://doi.org/10.9734/bpi/crpps/v1/208

A Potential Gateway to the Diagnosis of Chronic Diseases: Radioisotopes of Thallium | Chapter 9 | Current Perspective to Physical Science Research Vol. 3

 This study highlights about biomedical use of radioisotopes of Thallium. Radioisotopes are generally used to detect cracks in heavy mechanical systems, leak detection in long pipelines, and detect nuclear activities from nuclear weapons. Now a days, nuclear medicine is a specialized area of radiology that uses very small amounts of radioactive materials, or radiopharmaceuticals inside the body, to examine organ function and structure for diagnosis or to target and destroy damaged or diseased organs or tissue. Presently, different types of radionuclides are available, which include forms of the element technetium, thallium, gallium, iodine, and xenon but out of these thallium's radioisotope plays a crucial role in diagnosing chronic ailments like coronary artery disease (CAD) caused myocardial infarction, ischemia, etc. These diseases cause specific muscles or arteries to die or get blocked. Thallium acts as a radiopharmaceutical agent used for various purposes like purpose of CAD, parathyroid activity, coronary artery ischemia, and lymphoma. Out of the radioisotopes of thallium (201Tl) is best suited for diagnosing such diseases by tomography techniques like Single Photon Emission Computed Tomography (SPECT). In this chapter, an overview of how thallium can be used in a nuclear medicine to test the stress level in CAD mechanism of action as a tracer and perfusion imaging test by using SPECT is given. Diagnosis of Heart Conditions which help physicians identify regions of the heart that may be damaged or stressed, in Stress Testing by assessing the severity of coronary artery blockages and identifying areas of reduced perfusion during stress.

Author(s) Details:

D. P. Singh,
Department of Physics, School of Engineering Studies, University of Petroleum & Energy Studies, Dehradun-248007, Uttarakhand, India.

 Please see the link here: https://stm.bookpi.org/CPPSR-V3/article/view/12868