Microsponge is a porous polymeric microsphere and a tiny sponge-like spherical particle. It is a novel, unique and futuristic approach to drug delivery in a well-framed manner. Using this approach, regulated delivery of drugs may now be gained quickly as well as safely. This system is a patented system of tiny particles, made up of very tightly connected, polymer-based microporous spheres filled with active ingredients, each containing many small, interconnected empty spaces. Sponge micro particulates have gained the interest of researchers for pharmaceutical applications due to their exceptional features, which include high porousness, elastic deformation, capillary action, and three-dimensional (3D) response surroundings. Sponge particles are particularly promising for medication administration, tissue engineering, and wound repair due to their large reservoirs with extensive surfaces and interior networks for cargo sheltering and shuttling. Topical drug delivery is the exclusive application of microsponge but later on, the other application routes of drug delivery like oral, pulmonary and parenteral were also used. One of the most excellent features of the microsponge is it is self-sterilizing. The release and loading of drugs were studied by researchers and indicated the properties responsible for them. This review focused on the incorporation of drugs in microsponges, fabrication methods, characterization parameters, and biomedical applications of microsponges. Near future, it will be quite useful in exploring the microsponge delivery systems (MDS) in different disorders. So, the objective of this work was to provide recent and updated information on Microsponges as smart carriers for drug delivery in Pharmaceutical research. Author(s) Details Ranu Biswas Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, WB, India. Md. Ahesan Ansari Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, WB, India. Sourav Mondal Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, WB, India. Pritam Kapat Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, WB, India. Arindam Ghosh Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, WB, India. Shounak Sarkhel JIS University, 81, Nilgunj Road, Deshpriya Nagar, Agarpara, Kolkata-700109, WB, India. Please see the book here: - https://doi.org/10.9734/bpi/prrat/v4/1560

 

Microsponge is a porous polymeric microsphere and a tiny sponge-like spherical particle. It is a novel, unique and futuristic approach to drug delivery in a well-framed manner. Using this approach, regulated delivery of drugs may now be gained quickly as well as safely. This system is a patented system of tiny particles, made up of very tightly connected, polymer-based microporous spheres filled with active ingredients, each containing many small, interconnected empty spaces. Sponge micro particulates have gained the interest of researchers for pharmaceutical applications due to their exceptional features, which include high porousness, elastic deformation, capillary action, and three-dimensional (3D) response surroundings. Sponge particles are particularly promising for medication administration, tissue engineering, and wound repair due to their large reservoirs with extensive surfaces and interior networks for cargo sheltering and shuttling. Topical drug delivery is the exclusive application of microsponge but later on, the other application routes of drug delivery like oral, pulmonary and parenteral were also used. One of the most excellent features of the microsponge is it is self-sterilizing. The release and loading of drugs were studied by researchers and indicated the properties responsible for them. This review focused on the incorporation of drugs in microsponges, fabrication methods, characterization parameters, and biomedical applications of microsponges. Near future, it will be quite useful in exploring the microsponge delivery systems (MDS) in different disorders. So, the objective of this work was to provide recent and updated information on Microsponges as smart carriers for drug delivery in Pharmaceutical research.

 

Author(s) Details

Ranu Biswas
Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, WB, India.

Md. Ahesan Ansari
Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, WB, India.

Sourav Mondal
Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, WB, India.

Pritam Kapat
Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, WB, India.

Arindam Ghosh
Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, WB, India.

Shounak Sarkhel
JIS University, 81, Nilgunj Road, Deshpriya Nagar, Agarpara, Kolkata-700109, WB, India.

 

Please see the book here: - https://doi.org/10.9734/bpi/prrat/v4/1560

Development and Validation of UV-Spectrophotometric Method for the Determination of Lornoxicam in Microsponges | Chapter 11 | Technological Innovation in Pharmaceutical Research Vol. 4

 Objective: To develop and verify a new UV-spectrophotometric method for estimating the amount of lornoxicam in microsponges that is specific, precise, and simple. Lornoxicam is an oxicam-class non-steroidal anti-inflammatory medication (NSAID) with analgesic, anti-inflammatory, and antipyretic (fever-reducing) effects.

Thermo Scientific Evolution 201 UV-Vis spectrophotometer was used to make UV-spectrophotometric measurements with methanol as the medium. The absorption maximum (max) of the standard solution was determined by running its spectra from 200 to 400 nm. Lornoxicam has a maximum wavelength of 353 nm. The absorbance of standard solutions containing 3, 6, 9, 12, and 15 g/ml of drug solution was measured against a blank at an absorption maximum of 353 nm. The concentration was then plotted on the X-axis and the absorbance on the Y-axis, yielding a straight line. As per ICH recommendations, validation criteria such as linearity and range, selectivity and specificity, LOD and LOQ, accuracy, precision, and robustness were assessed.

With a correlation coefficient of 0.9995, the UV-spectrophotometric technique was found to be linear over a concentration range of 3.0-15.0 g/ml. Lornoxicam has a limit of detection (LOD) of 1.26 g/ml and a limit of quantification (LOQ) of 3.82 g/ml, respectively. The accuracy ranged from 99.21 to 99.60 percent. The percent RSD for repeatability, intraday precision, and interday precision was determined to be 0.473, 0.478-0.619, and 0.855-1.818, respectively. The UV technique proposed is shown to be reliable.

Conclusion: The suggested UV-Visible spectrophotometric method was verified using ICH recommendations, and the findings and statistical parameters showed that the developed method is sensitive, precise, reliable, and easy for estimating the amount of lornoxicam in microsponges.

Author (s) Details

Ayya Rajendra Prasad
Department of Pharmaceutics, Nirmala College of Pharmacy, Mangalagiri 522503, Andhra Pradesh, India.

Bannaravuri Thireesha
Department of Pharmaceutics, Nirmala College of Pharmacy, Mangalagiri 522503, Andhra Pradesh, India.

View Book :- https://stm.bookpi.org/TIPR-V4/article/view/1503