Trends in Evolution of Anthelminthic Chemical Agents: Ecological, Physiological and Biochemical Adaptation in Helminth | Chapter 12 | Technological Innovation in Pharmaceutical Research Vol. 4

 In this study, the key anthelminthic compounds are discussed, including alternative medicine components, different types of pluripotent manufactured and naturally occurring compounds. The sections devoted to recent discoveries (Emodepside, Monepantel, Derquantel, Tribendimidine) and certain promising efforts receive a lot of attention. The overview also covers molecular mechanisms of action of anthelminthic substances, helminth adaptation to anthelminthic chemicals, and alternative worming therapies. Synthetic non-organic and organic or natural compounds are used as antihelminthic agents. The hypothesis on the viability of the targeted search for such compounds among the derivatives of conditionally progenitor cyclic hydrocarbons – benzene, indene, naphthalene, 1H-cyclopenth [a]-naphthalene, and phenanthrene – by alternating absolutely unsaturated and saturated structures, is based on a systemic analysis of particular features of the chemical structure of anthelminthic substances.

Author (s) Details

M. Kh. Dzhafarov
K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, 109472 Moscow, ul. Akademika Skryabina, Russia.

F. I. Vasilevich
K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, 109472 Moscow, ul. Akademika Skryabina, Russia.

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Assessing the In Vitro Antioxidant Activity of Withania somnifera Root | Chapter 8 | Current Perspectives on Chemical Sciences Vol. 6

 Due to their structural sophistication, chemical diversity, lack of significant toxic effects and a wide range of antimicrobial activity, conventional herbal medicines are new therapeutic candidates. It can be found in the Mediterranean, Africa, and India. Objective: To test and compare the in vitro antioxidant activity of the indigenous Withania somnifera methanol extract to that of the imported root extract. Methods: ABTS•+ radical cation de-colorization assay, DPPH• radical scavenging activity, radical scavenging activity of nitric oxide, Fe2+ chelating activity assay, radical scavenging activity of superoxide anion and hydrogen peroxide and power reduction of ferrous were examined. Results: Comparatively stronger antioxidant activity was observed for indigenous root extracts than for imported root extracts. Conclusion: The indigenous root data obtained from these studies were high compared to the imported root extracts which showed higher antioxidant activity in Withania somnifera indigenous root. Thus, the isolation of Withania somnifera bioactive compounds would certainly serve as a good phytotherapeutic agent. Compared to the imported root extract, the indigenous root extract showed high antioxidant capacity. The present study of the antioxidant activities of Withania somnifera root in Bangladesh is the first ever paper.

Author(s) Details

Ratan Kumar Paul
Department of Chemistry, Pabna University of Science and Technology, Pabna, Bangladesh and Department of Chemistry, Bangladesh University of Engineering & Technology, Dhaka, Bangladesh.

Dali Rani Sarker
Department of Chemistry, Pabna University of Science and Technology, Pabna, Bangladesh.

Md. Saifur Rahaman
Institute of Radiation and Polymer Technology, Atomic Energy Research Establishment, Bangladesh Atomic Energy Commission, Dhaka, Bangladesh.

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