Showing posts with label endometrial carcinoma. Show all posts
Showing posts with label endometrial carcinoma. Show all posts

Thursday, 30 June 2022

Histopathological Pattern of Endometrium in Abnormal Uterine Bleeding: A Prospective Study | Chapter 7 | Current Practice in Medical Science Vol. 3

By examining histological results in endometrial tissue samples, the current study establishes the most prevalent age group and frequent pathology producing abnormal uterine bleeding.

Abnormal uterine bleeding is one of the most common presenting symptoms in the gynaecology outpatient department (AUB). Unusual uterine bleeding for which there is no known cause is referred to as "dysfunctional uterine haemorrhage." For individuals who have abnormal uterine bleeding, it is essential to assess the endometrium's histological appearance. A beneficial initial step in the diagnosis of DUB may be an endometrial biopsy. This prospective research was conducted in the departments of pathology at Bhaskar Medical College and Satya Diagnostic Center in Hyderabad, Telangana State, on patients who presented with abnormal uterine haemorrhage. The research lasted for a total of two years, from June 2014 to November 2016. For the final analysis, 150 endometrial lesions with histopathological diagnoses were chosen. The dilatation and curettage (D&C) procedure was used to collect all of the endometrial samples included in the study. The patients' ages varied from 21 to 78 years old, with a mean of 49.5 years. Endometrial polyp, complex hyperplasia without atypia, endometrial cancer, pill endometrium, complex hyperplasia with atypia, endometritis, atrophic endometrium, and adenomatous hyperplasia were among the other patterns found. Age pattern and endometrial causes of DUB were statistically significant with a P value 0.05. In order to rule out cancer, a thorough histopathological examination of the endometrium should be performed on women who report with abnormal uterine bleeding, especially beyond the age of 40. In situations of dysfunctional uterine haemorrhage, it is helpful for diagnosis, to evaluate treatment response, and to understand the pathological incidence of organic lesions before surgery. In different types of AUB, D&C shows endometrial patterns and also aids in ruling out any organic disease. The endometrium should thus be histopathologically examined in women over 40 to rule out preneoplastic lesions and cancer.

Author(s) Details:

V. Vijay Sreedhar,
Department of Pathology, Bhaskar Medical College, Ranga Reddy District, Telangana State, India.

Ch. Jyothi,
Gandhi Medical College, Secunderabad, Telangana State, India.

M. Narsing Rao,
Department of Pathology, Bhaskar Medical College, Ranga Reddy District, Telangana State, India.

V. Sailaja,
Department of Pathology, Bhaskar Medical College, Ranga Reddy District, Telangana State, India.

M. N. P. Charan Paul,
Department of Pathology, Bhaskar Medical College, Ranga Reddy District, Telangana State, India.

G.Vijaya Lakshmi,
Department of Obg and Gynecology, Bhaskar Medical College, Ranga Reddy District, Telangana State, India.

Sunday, 26 July 2020

Assessment of Microvessel Density and Angiogenesis in Endometrial Carcinomas | Chapter 7 | Research Trends and Challenges in Medical Science Vol.3 Assessment


Objective: To evaluate the role of angiogenesis in tumor growth by the assessment of microvessel density and to quantify angiogenesis as an important variable in endometrial cancers.  Materials and Methods: 103 cases of endometrial malignancies (epithelial tumors-76 cases, stromal tumors-07 cases and metastatic tumors-20 cases) were analysed for histological types, grades and features like depth of invasion and vascular invasion. Microvessel counts were performed by examining the microvessels thoroughly in terms of count, morphology and density after staining the tissues by hematoxylin & eosin stain, reticulin and immunostain CD34. Results: On H&E stain - Microvessel density (MVD) in endometrial malignancy ranged from 3.0 - 13.5 and mean MVD was 8.78. On Reticulin stain - MVD ranged from 3.5 - 15.2 and mean MVD was 9.76.  CD34 sections showed very small microvessels or even single endothelial cells with the highest total counts and the MVD ranged from 6.5-16.8 with Mean MVD of 11.7. The counts increased with the grade of the tumor in the absence of necrosis or haemorrhage. MVD counts also increased with the stage, being 8.12 in Stage I disease, 8.65 in Stage II and 10.8 in stage III disease. Atypical hyperplasia was found to be associated with epithelial tumors in 8 cases, making it a significant finding. Conclusions: Role of angiogenesis assumes greater significance with increasing severity of lesions, higher grade and stage of the tumor and seems to have an important diagnostic and prognostic significance. 


Author(s) Details
 Dr. Kafil Akhtar
Department of Pathology, Jawaharlal Nehru Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh,  U. P. -202002, India.  

Dr. Sumbul Warsi
Department of Pathology, Jawaharlal Nehru Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh,   U. P. -202002, India.

Dr. Rana Khalid Sherwani
Department of Pathology, Jawaharlal Nehru Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh,   U. P. -202002, India.

View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/211