Counting Cell Divisions: A Computational Approach Using DNA Tandem Repeats | Chapter 2 | Microbiology and Biotechnology Research: An Overview Vol. 2

Repetitive DNA occurs in all domains of life—Bacteria, Archaea and Eukaryota—and can be grouped into two categories: interspersed repeats, such as transposable elements occurring in multiple loci across the genome, and tandem repeats (TRs) that occur in a single locus. This manuscript presents a compelling exploration of the role of DNA tandem repeats (TRs) in counting cell divisions, employing a computational model that could significantly advance the understanding of cell biology and epigenetics. The integration of TRs as iterable objects not only offers a fresh perspective but also provides a potential framework for investigating fundamental biological processes. The research could pave the way for novel insights into cellular mechanisms and their implications for development and disease. Overall, this manuscript aims to be a contribution to the scientific community, encouraging deeper discussions about the noncanonical roles of TRs in genomic regulation.

 

Author (s) Details

Marco Franco Giulio Regolini
MFR Bioengineering – Audiologic, Via Dei Gracchi 30, 20146 Milano, Italy.

 

Please see the book here:- https://doi.org/10.9734/bpi/mbrao/v2/4726

Assessing the Effects of Thermal Stimulation on Skeletal Muscle-Derived Cell Density | Chapter 10 | Recent Developments in Medicine and Medical Research Vol. 7

 We looked into whether thermal stimulation could help prevent atherosclerotic cardiovascular disease in the past (ASCVD). Variations in the expression of associated genes were validated in studies utilising human skeletal muscle-derived cells (SMDC). A small decrease in the number of cells was also verified. The application of thermal stimulation to cultured cells has long been connected with apoptosis. Although various research have confirmed the above, such as promoting apoptosis and decreasing apoptosis with heat stimulation, the precise effects of thermal stimulation on apoptosis have yet to be determined. In order to safely use heat stimulation for the prevention of ASCVD in vivo, we reexamined the effects of thermal stimulation on human skeletal muscle cells. We hypothesised that thermal stimulation of SMDC causes apoptosis based on our previous findings. This suggested that in order to prevent ASCVD in vivo, heat stimulation should be moderate.

Author(S) Details

Masayo Nagai
Department of Nursing Faculty of Health Science, Aino University, Japan.

Hidesuke Kaji
Division of Physiology and Metabolism, University of Hyogo, Division of Pathophysiology, Kobe Women’s University, Japan.

View Book:- https://stm.bookpi.org/RDMMR-V7/article/view/4535