Biocatalysed Stereoselective Synthesis of Chiral Nitro Alcohols | Chapter 9 | Progress in Chemical Science Research Vol. 7

 Chiral nitro alcohols are versatile intermediates used in the synthesis of important pharmaceuticals and chiral synthones. During the past decade, the search for greener and more sustainable synthetic procedures has promoted the investigation of biocatalysed strategies for the synthesis of enantiopure nitro alcohols. In this article, stereoselective synthesis of chiral nitro alcohols by biocatalytic reduction of acetophenone and 2-, 3-, 4-nitro acetophenone, 3-nitro-4-methyl acetophenone and 3-nitro propiophenone was accomplished using Rhizopus arrhizus NCIM 878 to yield corresponding (S) -nitro alcohols in good yield and ee (70-87%). However, the biotransformation is very sensitive to the effect of substituent methyl group on aromatic ring and on side chain which proves its structure-activity relationship.

Author(s) Details:

Prabha R. Salokhe,
Department of Chemistry, Yashwantrao Chavan Warana Mahavidyalaya, Warananagar (MS), India.

Rajeshri S. Salunkhe,
Department of Chemistry, Bio-Organic Lab, Shivaji University, Kolhapur – 416004, (MS), India.

Please see the link here: https://stm.bookpi.org/PCSR-V7/article/view/10013

Microbial Degradation and Transformation of Organic Pollutants: An Eco-Friendly Strategy for Waste Mitigation | Chapter 2 | Recent Progress in Microbiology and Biotechnology Vol. 6

 Organic waste pollution, particularly hydrocarbons, pesticides, herbicides, and other toxic wastes, is a worldwide issue. Despite the economic boom created by the petroleum industries in many countries, it has also resulted in environmental and socioeconomic challenges. The main cause of water and soil pollution is the accidental or intentional release of hydrocarbons into the environment. Pesticide applications on agricultural soil are now commonplace. Some of these pesticides persist in the soil, forming pollutants that may harm the environment. This can occasionally result in surface and ground water contamination. The role of microorganisms in organic pollutant biodegradation is an important subject to research because it is a safe alternative to physicochemical techniques. The general principles of organic pollutant degradation by microorganisms were summarized in this paper. The biochemistry of hydrocarbon oxidation, specifically the terminal and sub terminal oxidation of n-alkanes, as well as the anaerobic degradation of alkanes, was highlighted. The paper also discussed the biodegradation pathways of organic chemicals such as pesticides, as well as the factors influencing organic pollutant biodegradation. Aside from these factors influencing biodegradation, efforts to improve microorganisms' biodegradative capabilities through biostimulation, bioaugmentation, and the use of genetically engineered microorganisms (GEM) were also discussed.

Author (S) Details

Dr. A. E. Mbachu
Department of Applied Microbiology and Brewing, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Nigeria.

E. I. Chukwura
Department of Applied Microbiology and Brewing, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Nigeria.

N. A. Mbachu
Department of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.

View Book :- https://stm.bookpi.org/RPMB-V6/article/view/1676