Diabetic Cardiovascular Neuropathy: Effects of Benfotiamine on Heart Rate Variability| Chapter 5 | Challenges and Advances in Pharmaceutical Research Vol.3

The importance of cardiovascular autonomic neuropathy (CAN) is underappreciated, and there is no standardised treatment protocol. The purpose of this study was to see how benfotiamine (BFT) affected heart rate variability (HRV) in individuals with T2DM and CAN. A total of 32 people with T2DM with confirmed CAN were randomly allocated to one of two treatment groups: BFT 300 mg/d was given to Group 2 (n=17) in addition to their regular antihyperglycemic medication for three months. Heart rate variability (HRV) parameters were investigated. BFT was shown to increase the sum of squares of variations between consecutive normal-to-normal intervals, as well as the high-frequency component of HRV, throughout both active and inactive sections of the day. BFT's positive outcomes imply that it might be used to treat persons who have T2DM and a confirmed stage of CAN.

Author(s) Details:

Victoria A. Serhiyenko,
Department of Endocrinology, Danylo Halytsky Lviv National Medical University, 79010, Lviv, Ukraine.

Marta E. Hotsko,
Department of Endocrinology, Danylo Halytsky Lviv National Medical University, 79010, Lviv, Ukraine.

Alexandr Serhiyenko,
Department of Endocrinology, Danylo Halytsky Lviv National Medical University, 79010, Lviv, Ukraine.

Please see the link here: https://stm.bookpi.org/CAPRV-3/article/view/6945

A Brief Study on Type 2 Diabetes Mellitus and Benfotiamine | Chapter 12 | Issues and Development in Health Research Vol. 3

 Supplementing with benfotiamine (BFT) may help to prevent various diabetes-related vascular and neuronal complications. The mechanism by which BFT influences diabetes angiogenesis and neuropathies pathogenesis is unknown. This mini-review intended to examine the most recent information on the impact of benfotiamine (a lipid-soluble thiamine derivative with better bioavailability than thiamine) on some metabolic and functional parameters in T2DM patients with diabetic angio-, neuropathies. To confirm the beneficial effect of BFT on biochemical parameters, dynamics of independent cardiovascular tests, daily monitoring of electrocardiography, arterial wall stiffness parameters among patients with type 2 diabetes mellitus, diabetic angio-, neuropathies, and their associated comorbidities, more research is needed.

Author (S) Details

Victoria A. Serhiyenko
Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Ukraine.

Alexandr A. Serhiyenko
Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Ukraine.

View Book :- https://stm.bookpi.org/IDHR-V3/article/view/3306