Morpholine Based Tetrazole Hybrids as Anti-Oxidant Agents and Their Theoretical Studies | Chapter 3 | Recent Developments in Chemistry and Biochemistry Research Vol. 7

Using Cu-promoted regioselective N-arylation and C-N bond formation reactions, various tetrazole hybrids, designated 7a–l, were synthesized and evaluated for their in vitro antioxidant efficacy. Spectroscopic methods like 1H NMR, 13C NMR, IR, and LCMS were used for the characterization of the prepared compounds and all the data was in good agreement with the anticipated structures. The prepared compounds 7a-j were screened in vitro for antioxidant activity by DPPH radical scavenging method and the screening outcome revealed that the prepared compounds 7d, 7e and 7k are the most potent among all the examined compounds and the remaining compounds were moderately active. Moreover, the theoretically calculated HOMO-LUMO energies and their energy gap, hardness, softness, and chemical potential of the obtained chemical components 7a-j are investigated by using the model of B3lyp/6-31g(d,p) in the Gaussian package. The theoretical investigation reveals that the compounds 7d, 7e and 7k are chemically more reactive than other obtained tetrazole compounds.

 

Author (s) Details

B. S N Murthy
Department of Chemistry, Sir C R Reddy College (Autonomous), Eluru, A.P-534007, India.

 

S. Aravind
Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad, Telangana, India.

 

T. Kiran Kumar
Department of Natural Products and Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka-500007, Hyderabad, Telangana, India.

 

T. Somasekhar
Department of Humanities and Sciences, Vidya Jyothi Institute of Technology, Himayat Sagar Rd, Aziznagar Gate, Hyderabad, Telangana-500075, India.

 

Surinderpal Singh
Department of Chemistry (H&S), CMR Engneering College, Kandlakoya (V), Hyderabad, Telangana-501401, India.

 

K.A. Emmanuel
Department of Chemistry, Y.V.N.R Government Degree College, Kaikaluru, A.P., India.

Johar K
Department of Chemistry, Sir C R Reddy College (Autonomous), Eluru, A.P-534007, India.

 

Manoj Kumar B.V
Department of Chemistry, Sir C R Reddy College (Autonomous), Eluru, A.P-534007, India.

 

Satish V.A.N
Department of Chemistry, Sir C R Reddy College (Autonomous), Eluru, A.P-534007, India.

 

 

 

Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v7/2429

A Review on the Pharmacological Effects of Curcumin in Diabetes, Cancer, and Neurodegenerative Diseases | Chapter 6 | Novel Aspects on Pharmaceutical Research Vol. 2

 As a diet-derivative agent, curcumin has been secondhand traditionally in many forms for the treatment of swelling and pain but most of the recent studies exposed the role of curcumin as an antidiabetic, anti-malignant, anti-infectious, antidepressant, and antipsychotic power. This dietary supplement has the ability to block any of cells indicating pathways at various levels which underlies allure diverse effect. By modulating cell phases and interacting directly accompanying molecular targets like glutathione peroxidase, basic factor kappa-B containers, cyclooxygenase-2, hepatic superoxide dismutase, reactive oxygen species swelling necrosis factors, etc. curcumin can halt the development of cancer. In this episode, we demonstrated the therapeutic belongings of curcumin in various cancers, neurodegenerative disorders, microbial contaminations, and diabetes interconnected with allure molecular pathways during preclinical tests.

Author(s) Details:

Nidhi Agrawal,
Siddhi Vinayaka Institute of Technology and Sciences, Mangla, Bilaspur (C.G.)–495001, India.

Hasnain Raza,
Siddhi Vinayaka Institute of Technology and Sciences, Mangla, Bilaspur (C.G.)–495001, India.

Meenakshi Jaiswal,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.)-495009, India.

S. K. Lanjhiyana,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.)-495009, India.

Manoj Kumar Sahoo,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.)-495009, India.

Please see the link here: https://stm.bookpi.org/NAPR-V2/article/view/10599