Efficacy and Safety of DR SKS Hair Growth Booster Serum in Adult Male and Female with Androgenic Alopecia | Chapter 3 | Research Developments in Medicine and Medical Science Vol. 10

 Aim: This study aims to investigate the clinical efficacy and safety of DR SKS Hair Growth Booster Serum – cocktail of micronutrients and multivitamins, in male and female patients with androgenic alopecia.

Background:  Androgenic alopecia is frequently encountered in dermatological practice; however, there is a lack of approved treatment. At present, only three therapies have been approved for on-label use in androgenetic alopecia  -minoxidil, finasteride, and lower-level laser therapy. Micronutrients are primary elements in the normal hair follicle cycle, and their role in androgenic alopecia is a growing matter of research nowadays.

Methods: We did a cross-sectional, multicentre, retrospective study across 5 hair clinic chains in India (Mumbai, Hyderabad, Jabalpur, Balaghat and Nagpur). Eligible participants were patients with a confirmed diagnosis of androgenic alopecia, aged 18 years or older and any gender. Each patient received DR SKS Hair Growth Booster Serum, 1 ml in volume, once a month by mesotherapy/dermaroller/dermapen. This therapy lasted six months in total. All patients were subjected to 60-second hair counts test (Comb test), hair pulled test, global photographic assessment, trichoscopy assessment, patient self-assessment questionnaire, and safety assessment at baseline and 6-month after the treatment.

Results: There was a significant reduction in hair fall with bulb (<0.0001) and without bulb (<0.0001) 6-month after the treatment vs baseline. There was a significant improvement in number of hairs removed per pull (<0.0001), global photographic assessment score (<0.0001), hair growth rate (<0.0001), follicular hair density (<0.0001), vellus hair density (<0.0001), and terminal hair density (<0.0001) 6-month after the treatment vs baseline. Majority of patients (98%) were satisfied with six months treatment of DR SKS Hair Growth Booster Serum. No major adverse events were reported during the study.

Conclusion: DR SKS Hair Growth Booster Serum was found to be a safe and effective treatment for androgenic alopecia, with 98% patient self-assessment score.

Author(s) Details:

Stuti Khare,
Elements of Aesthetics Clinics, Mumbai, India.

Please see the link here: https://stm.bookpi.org/RDMMS-V10/article/view/10674

Changes in HER-2 and Matrix Metalloproteinase-2 Expression in Bone Marrow Micrometastasis and Stromal Cells in Men with Prostate Cancer as a Result of Androgen Blockade| Chapter 9 | Perspective of Recent Advances in Medical Research Vol. 1

 We interpret an immunocytochemical analysis of the impact of androgen inhibition on HER-2 and cast metalloproteinase-2 (MMP-2) expression in cartilage marrow micrometastases and the surrounding stromal containers in prostate cancer patients. Men accompanying prostate cancer who endured bone essence biopsy procedures had touch prepare taken during androgen abolition, before and after radical prostatectomy.Patients were defined as HER-2 helpful or negative, MMP-2 negative or an MMP-2 pattern described as border or main and stromal MMP-2 defined as positive or negative. The verbalization of the biomarkers was compared before and after beginning treatment, as well as all the while androgen blockade, concerning serum PSA at the time of sample and time of androgen blockade.There were 191 males contained, 35 before surgery and 43 after; skilled were no appreciable alternatives in HER-2 expression between groups, and neither MMP-2 main nor stromal expression was present. MMP-2 expression in two together micrometastasis and stroma was found to be really related to HER-2 verbalization. MMP-2 expression at the micrometastasis barrier was not connected with HER-2 expression and happen in the absence of androgen blockade.Androgen need lowers serum PSA by destroying HER-2 negative prostate cancer cells. Early pick of HER-2 positive cancer containers, on the other hand, leads to androgen independence and embellished expression of MMP-2 venture in the micrometastasis. Increased MMP-2 activity in micrometastasis boosts MMP-2 expression in encircling stromal cells, which concede possibility promote angiogenesis and tumour growth, developing in macrometastatic androgen independent disease.

Author(s) Details:

N. P. Murray,
Hospital de Carabineros of Chile, Simon Bolivar 2200 Nunoa, 7770199 Santiago, Chile and Circulating Tumor Cell Unit, Faculty of Medicine, University Finis Terrae Santiago, Chile.

E. Reyes,
Hospital de Carabineros of Chile, Simon Bolivar 2200 Nunoa, 7770199 Santiago, Chile and Universidad Diego Portales, Manuel Rodriguez Sur 415, 8370179 Santiago, Chile.

L. Badinez,
Foundation of Arturo Lopez Perez, Rancagua 878, Providencia, 7500921 Santiago, Chile.

N. Orellana,
Hospital de Carabineros of Chile, Simon Bolivar 2200 Nunoa, 7770199 Santiago, Chile.

C. Fuentealba,
Hospital de Carabineros of Chile, Simon Bolivar 2200 Nunoa, 7770199 Santiago, Chile.

R. Olivares,
Hospital de Carabineros of Chile, Simon Bolivar 2200 Nunoa, 7770199 Santiago, Chile.

J. Porcell,
Hospital de Carabineros of Chile, Simon Bolivar 2200 Nunoa, 7770199 Santiago, Chile.

R. Duenas,
Hospital de Carabineros of Chile, Simon Bolivar 2200 Nunoa, 7770199 Santiago, Chile.

Please see the link here: https://stm.bookpi.org/PRAMR-V1/article/view/9004