Newborn sepsis is the most dangerous infection seen in the neonatal intensive care unit, with significant rates of morbidity and fatality. In this study, we looked at coagulase-negative Staphylococcus bacteria and their antibiotic susceptibility profiles in neonatal sepsis cases that were clinically indicated. The study's goals were to determine the importance of coagulasenegative Staphylococcus strains isolated from newborn sepsis cases, as well as another site for coagulase-negative Staphylococcus isolation other than blood culture and their susceptibility pattern. We investigated all instances of sepsis with a positive blood culture and accessible stool, central venous catheter, tracheobronchial, and nasopharyngeal fluid in a prospective study of babies hospitalised to our neonatal Intensive Care Unit between January 20th, 2017 and January 20th, 2019. Matrix-Assisted-Laser Desorption Ionization Time of Flight Mass Spectrometry was used to identify the strains. Patterns of antimicrobial susceptibility were recorded and studied. A coagulase-negative Staphyloccus-positive blood culture was found in 28 (17.8%) of the 157 preterm neonates in the study. Eighteen patients (64.2%) had early onset sepsis, while ten patients (35.8%) had late onset sepsis. There were 10 (35%) extremely preterm neonates, 12 (42.8%) very preterm newborns, and 6 (21.5%) moderately preterm newborns, according to gestational age at birth. 13 (46.4%) had an extremely low birth weight, 9 (32.2%) had an extremely low birth weight, 4 (14.2%) had a low birth weight, and 2 had a normal birth weight (7.2 percent ). All of the coagulasenegative Staphylococcus isolates had high levels of resistance to cefoxitin (100%), aminoglycosides (100%), fusidic acid, and ofloxacin (100 percent ). Pistinamycin (100%), vancomycin (100%), and trimethoprim-sulfamethoxazole (100%) were all highly susceptible to the isolates (100 percent ). The most common cause of newborn sepsis was Staphylococcus isolates that were coagulase-negative. Multi-drug resistance may evolve as a result of the abundance of these strains.
Author(s) Details
Andre Leke
Soins intensifs de Neonatologie et Medecine neonatale, CHU Amiens Picardie,
Site Sud, F- 80054, Amiens, France and Laboratoire Peritox INERIS UMR 101
CURS-UPJV, F-80054, Amiens, France.
Geraldine Amar
Reanimation Neonatale, Hopital Necker, 149 rue de Srevres, F-75015 Paris
Paris, France.
Bertin Elion Dzon
Services de Nutrition parenterale et de Chirurgie vasculaire, CHU Lille,
F-59000 Lille, France.
Guy Kongolo
Reanimation et Surveillance Continue Pediatrique, CHU Amiens Picardie Site
Sud, F-80054 Amiens, France.
Maurice Biendo
Laboratoire Peritox INERIS UMR 101 CURS-UPJV, F-80054, Amiens, France.
