An Overview on Bioenhancers| Chapter 7 | Challenges and Advances in Pharmaceutical Research Vol. 10

 A bioenhancer is an power that increases the bioavailability and bioefficacy of a medicine when added to it but has no pharmacological effect of allure own at the dose working. Bioenhancers should be inert, non-poisonous, compatible accompanying active pharmaceutical additives, cost-effective, constant, easy to formulate into miscellaneous forms, and readily free. Bioenhancers act by several mechanisms, in the way that alteration of fluency of the plasma membrane, therefore promoting inactive transcellular drug penetration; modulation of close junctions to allow for possibility increased paracellular diffusion; timbre of active efflux transporters in the way that P-gp-related outflow inhibition; inhibition of CYP enzymes in the stomach epithelium and liver, exerting cholagogue/choleretic effect; and utilizing thermogenesis. Popular herbal bioenhancers contain piperine, naringin, quercitin, curcumin, genistein, sinomenine, and capsaicin. The vast research to elaborate on the hopeful effects of using bioenhancers has proved promising consequences in both in-vitro and in-vivo studies. However, it is clear that there is at a great distance to go before we can adequately commercialise the use of bioenhancers in combination with cure to optimise the advantages of situations. This review shed light on various facets of bioenhancers.

Author(s) Details:

Mohammad Asif,
Faculty of Pharmacy, Lachoo Memorial College of Science and Technology, Shastri Nagar, Sector A, Jodhpur, 342001, Rajasthan, India.

Chandra Kala,
Faculty of Pharmacy, Maulana Azad University, Jodhpur, 342802, Rajasthan, India.

Tabassum Wasim Ahmad,
Department of Pharmaceutical Chemistry, Sant Gadge Baba Amravati University (SGBAU), Amravati, 444602, Maharastra, india.

Please see the link here: https://stm.bookpi.org/CAPR-V10/article/view/8801

Study on the Computational Nutraceutics of a Citrus Flavonoid: An Approach Using Conceptual Density Functional Theory (CDFT) | Chapter 10 | New Innovations in Chemistry and Biochemistry Vol. 1

 The goal of this study is to evaluate the M06 density functional family for calculating the molecular structure and characteristics of the Naringin flavonoid, as well as the chemical reactivity descriptors, using the Conceptual DFT (CDFT) technique. Using the Fukui function indices and the dual descriptor f(2), the active sites for nucleophilic and electrophilic assaults have been found (r). As a last verification of the validity of the previous technique, the descriptors produced using vertical energy values were compared to those derived using the Koopmans' theorem approximation.

Author (S) Details

Norma Flores-Holguin
Laboratorio Virtual NANOCOSMOS, Departamento de Medio Ambiente y Energia, Centro de Investigacion en Materiales Avanzados, Chihuahua, Chih 31136, Mexico.

Juan Frau
Departament de Quimica, Facultad de Ciencias, Universitat de les Illes Balears, Palma de Mallorca, E-07122, Spain.

Daniel Glossman-Mitnik
Laboratorio Virtual NANOCOSMOS, Departamento de Medio Ambiente y Energia, Centro de Investigacion en Materiales Avanzados, Chihuahua, Chih 31136, Mexico.

View Book :- https://stm.bookpi.org/NICB-V1/article/view/3353

The Importance of Fresh Consumption of Citrus Juices | Chapter 1 | Current Advances in Chemistry and Biochemistry Vol. 6

Two distinct reversed-phase high performance chromatographic methods were developed for the simultaneous determination of naringin, hesperidin, and organic acids in natural and commercial citrus juices. For naringin and hesperidin, the separation was achieved on a C18 column using an acetonitrile: water: formic acid (21:78.8:0.2) solution at pH 2.5 as a mobile phase under isocratic conditions. The analysis was performed at room temperature with a flow rate of 1 mL.min-1 and a total run time of 15 minutes. The wavelength of detection was set to 280 nm. Organic acids were separated chromatographically in a single run using isocratic mobile phase containing 10 mM. KH2PO4 (pH=2.2) at room temperature with a flow rate of 1 mL.min-1 on a C18 column in 10 minutes. The ultraviolet absorption was measured at 210 and 245 nm. Calibration linearity, accuracy, and precision were all investigated as part of the method validation. The improved method was used to analyze natural and commercial citrus juices. When compared to natural citrus juices, commercial fruit juices had lower levels of naringin, hesperidin, and organic acids.

Author (S) Details

E. Büyüktuncel
İnönü University, Faculty of Pharmacy, Department of Analytical Chemistry, Malatya, Turkey.

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Secretion of α-L-rhamnosidases by Few Aspergillus Fungal Strains Using Solid State Fermentation and Their Application in Debittering of Orange Fruit Juice | Chapter 8 | Recent Progress in Microbiology and Biotechnology Vol. 4

Alpha-L-rhamnosidase development from Aspergillus ochraceous MTCC -1810, A. MTCC Wentii-1901, A. MTCC Sydowii- 635, A. Using readily available agro-industrial residues such as corn cob, rice bran, sugarcane bagasse, wheat bran and citrus peel as substrate, foetidus MTCC-508 under solid-state fermentation. Among these, the best substrate was found to be sugarcane bagasse in combination with naringin and sucrose. The development of alpha-L-rhamnosidase was highest at 30 °C after the 4th day of incubation and the substrate to moisture ratio was 1:1 w/v. The maximal development of the enzyme was caused by supplementation of the medium with 10 percent naringin. The alpha-L-rhamnosidases temperature optima and pH optima were calculated in the range of 50-60 °C and 4.0-5.0 respectively. For the debittering of orange fruit juice, the alpha-L-rhamnosidases secreted from the above fungal strains are appropriate. In the achievement of the above goal, the studies mentioned in this communication will be helpful.

Author(s) Details

Dr. Sarita Yadav
Department of Chemistry, DDU Gorakhpur University, Gorakhpur-273009, Uttar Pradesh, India.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/359