Background: Age of contraceptives, abortions,[20th, 21st centuries] initiated as observed by family welfare programs, increased global cancer, tumor, neoplasm and mortality incidence.
Objectives: Tumor altruistic association of contraception [if any] with growing
cancer has been tried.
Methods: in 2012, retrospective study of cancer prevalence, tumor in 350
patients 20-35 years of age, 35-50 years of age, >50 years of age, from data
collected by convenient stratified random sampling from different geographical
locations between 2002-2012 and its association with presence, absence of
contraception, abortion was performed; simultaneously, serum oestrogen levels
were obtained from different geographical locations between 2002-2012 and its
association with presence, absence of contraception, abortion; 212 patients
treated for various forms of neoplasm, namely breast cancer, prostate cancer,
cervix cancer and benign prostatic hyperplasia, were randomly allocated to the
above 3 age groups from 1983-2012 clinical practice, and the data were analyzed
for association with contraceptive status and potential significance.
Results: There was a 6-fold rise in the incidence of cancer among contraceptive
users over >50 years with a p-value of <0.0005. Contraception was
associated with a 4 to 7 fold increase in tumor prevalence with a p value of
<0.0005 between >35 and >50 years. In 61 percent of contraceptive
users with a p value of <0.0005, endogenous estrogen decreased to ~5-8 pg;
endogenous estrogen values of up to ~0.4 pg were seen after hysterectomy. Due
to reduced production of endogenous estrogen, diet deprived of cholesterol:
androgen was also correlated with a 50 percent rise in tumor, cancer in youth
without contraceptives. In well-differentiated breast cancers, associated with
decreased levels of endogenous estrogen among contraceptive users, estrogen
receptors were positive, indicating that estrogen receptor positivity may be a
compensatory phenomenon; estrogen receptor positivity was not shown in
anaplastic tumors. There was a 10-20 fold increase in breast cancer between
20->50 years, in contraceptive patients with a p-value of <0.0005; a
20-30 fold increase in prostate cancer between 35->50 years, in
contraceptive patients with a p-value of <0.0005; in contraceptive patients
with a p-value of <0.0005; in cervical patients with a 20-40 fold increase
between 20-70 years; in contraceptive patients with a p-value of <0.0005.
Conclusion: Contraception of any sort results in shattered germ cell breakdown
to centric fragments, ring chromosomes, chromatid breaks, auto immunity
generation, substantial decrease in endogenous, reproductive hormones, without
which genomic repertoire: embryo-like healing mechanism defaults, leading to a
275% rise in disease incidence, including cancers. Definition is acquired
contraception preventing traversal of normal path by germ cells with consequent
shattered destruction of germ cells, resulting in decreased endogenous
estrogen: androgen surveillance, resulting in agonizing cellular genomic
repertoire defects, unregulated multiplication followed by no cell cycle
differentiation, metabolism, resulting in high cancer incidence, including.
Increased estrogen receptors: androgen receptors in breast and
well-differentiated prostate cancers are likely to be a compensatory spike,
secondary to sudden artificially obtained contraception, resulting in a
substantial reduction in contraceptive consumers of endogenous germ cell
hormones. Reversal of contraception with chemotherapy, radiation therapy,
surgery achieves preventing cancer development, decreases incidence, prevalence
of neoplasm, as a phenomenon of cause and effect and not castration or anti-estrogen:
antiandrogens that perpetuate, encourage neoplastic diseases by decreasing
endogenous estrogen: androgen.
Author (s) Details
Department of General Medicine, Karpagam Faculty of Medical Sciences and Research, Coimbatore-32, Tamil Nadu, India.
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