The main objective was to determine how perioperative FXIII levels affected ICH following brain surgery. An 18-month prospective observational study was conducted at a Spanish third-level hospital. It comprised all consecutive adults (18 years or older) who underwent elective brain tumour surgery and underwent postoperative care in the Neurointensive Care Unit (N-ICU). Ages under 18, informed refusals, deaths in operating rooms, inadequate blood samples, and non-tumor tissue were prohibited. FXIII levels in three blood samples were measured (A-presurgical, B-postsurgical and C-24 hours after surgery). The study involved 109 patients. Final ICH confirmation was made in 39 of them (35,78 percent). An association between the length of the ICU stay (p0,01) and the male gender (p0,03) and the ICH was found by inferential studies. Particularly in the B sample, ICH patients' average FXIII was lower (A 71,2 percent, B 51,57 percent, C 52,14 percent). After brain tumour surgery, acquired FXIIID (70%) elevated ICH, indicating that it might be employed as a risk marker for haemorrhage. Additionally, male gender, baseline variation, and a longer ICU stay were all associated with ICH. Tests for normal coagulation did not exclude FXIII disease. Future research may focus on FXIIID detection and replacement therapy as a therapeutic goal.
Author (s) Details
Estela Val Jordan
Department of Critical
Care, Hospital Universitario Miguel Servet, Paseo Isabel La Católica, 1-3.
50009, Zaragoza, Spain.
Please see the link here:- https://stm.bookpi.org/CPMS-V8/article/view/7798
