GLP-1 Receptor Agonists: Mechanisms, Insights, and the Impact of Wegovy and Ozempic on Contemporary Weight Management | Chapter 7 | Pharmaceutical Research: Recent Advances and Trends Vol. 6

Aims: This book chapter aims to provide a comprehensive exploration of the unintended consequences of the misuse of Wegovy and Ozempic in weight management, expanding on a previously published review article.

 

Methodology: The chapter incorporated recent data and insights into the use of GLP-1 receptor agonists for weight management. The data and analysis presented in this chapter are derived from an extensive review of the current literature and clinical studies up to July 2024. This work synthesizes findings from clinical trials, observational studies, and meta-analyses to evaluate the efficacy, safety, and long-term effects of GLP-1 receptor agonists, particularly Wegovy and Ozempic, in both diabetic and non-diabetic populations. It examines the pharmacological mechanisms, dosing considerations, potential drug interactions, and the overall impact on metabolic health.

 

Results: The chapter highlights that GLP-1 receptor agonists such as Wegovy (Semaglutide) and Ozempic (Semaglutide) are effective in promoting significant weight loss. These agents improve glycemic control and reduce body weight through multifaceted mechanisms, including enhanced insulin secretion, inhibition of glucagon release, delayed gastric emptying, and increased satiety. Clinical evidence shows substantial weight reduction and favorable cardiovascular outcomes in obese individuals. However, the off-label use of these medications for weight management without diabetes raises concerns about safety and long-term effects.

 

Conclusion: The misuse of Wegovy and Ozempic for weight management, while offering promising results, necessitates careful consideration of potential risks and benefits. Future research should focus on long-term safety profiles, optimal dosing strategies, and monitoring protocols to mitigate adverse effects and maximize therapeutic outcomes in diverse patient populations. This chapter underscores the importance of balancing efficacy with safety in the use of GLP-1 receptor agonists for obesity management.

 

 

Author (s) Details

Madhura S. Chothave
MGV’s Pharmacy College, Nashik, India.

 

Anupama A. Kapadnis
MGV’s Pharmacy College, Nashik, India.

 

Manoj J. Jagtap
MGV’s Pharmacy College, Nashik, India.

 

 

Please see the book here:- https://doi.org/10.9734/bpi/prrat/v6/2151

 

Behavior Therapy in Curing Depression for Adolescents with Sickle Cell Disease | Chapter 2 | Advanced Concepts in Medicine and Medical Research Vol. 10

Cavity has been identified all at once of the commonest insane-health problems in SCD, accompanying prevalence rates as extreme as 27% - 46% reported [1]. While psychological cures have been establish to be beneficial in gentle to moderate depression, their use as non-pharmacological orders amongst adolescents in substitute-Saharan Africa, specifically Nigeria, is still at its infancy. This member determines the effect of behavioural incitement therapy on depression in juveniles living with Cut Cell Disease accompanying out-patient clinic at the Lagos State Academy Teaching Hospital, Lagos, Nigeria. The study was conducted in Lagos State Academy Teaching Hospital, Lagos, Nigeria, 'tween November 2017 to February 2018 (4 months) among adolescents endure SCD and depression accompanying out-patient clinic. The participants were a sample of agreeing adolescents (12 - 17 age) with SCD who had temperate to moderate depression. We forbade those with severe cavity on anti-sedative medications. The participants were detached into two groups, the treatment group and wait list (control) group. A randomized control trial (RCT) was transported among participants filling a place treatment (30) against control (30) group. A manualized behavioral therapy programme developed was brought to the treatment group. The dossier was analysed using the Statistical Whole for Social Sciences (SPSS) form 23. Pair T-test was used to compare the two groups across constant variables, pre- and post-intervention. Study of Covariance (ANCOVA) was used to deter- mine treatment belongings controlling for standard scores. After the inter- vention, the mean despair score reduced from 22.13 ± 3.08 to 13.02 ± 4.56 while Paediatric feature of life score increase from 62.57 ± 17.85 to 67.90 ± 7.99 in the treatment group (BDI, p < 0.001; PedsQL, p = 0.045). Nevertheless, the pre- and post-intervention mean concavity scores in the control group showed insignificant decline from 22.23 ± 3.24 to 21.60 ± 2.75 and mean PedsQL from pre-intervention scores of 59.67 ± 12.60 to 56.73 ± 8.94 post attack (BDI, p = 0.388; PedsQL, p = 0.242). From multivariate analysis (ANCOVA), only the Quality of Growth scores ceased to show some significant effect of the intervention.Finally, the effect of behavioral incitement therapy (BAT) in juveniles with SCD and gentle to moderate depression using a randomized reserved trial has been grown. The results reflected that BAT happened in significant betterings in self-reported rating of depressing symptoms (effect intensity 2.1) and depression literacy suggesting productiveness of BAT in relieveing depressive symptoms in this place cohort, still the QoL scores initially appeared to have had a beneficial change but ceased expected so after controlling for likely confounders.

Author(s) Details:

Tolulope Taiwo,
Lagos State University Teaching Hospital, Lagos State University, Lagos, Nigeria and Crisis Resolution and Home Treatment Team (CRHTT), Birmingham Womens and Children NHS Trust, UK.

Olayinka Atilola,
Department of Behavioral Medicine, Lagos State University College of Medicine, Lagos, Nigeria.

Cornelius Ani,
Division of Psychiatry, Imperial College London, Surrey and Borders Partnership NHS Foundation Trust, UK.

Bola A. Ola,
Department of Behavioral Medicine, Lagos State University College of Medicine, Lagos, Nigeria and Acute Mental Health Unit, Toowoomba Base Hospital, Queensland, Australia.

Please see the link here: https://stm.bookpi.org/ACMMR-V10/article/view/12816